STRINGSTRING
TMEM109 TMEM109 XRCC6 XRCC6 ERCC1 ERCC1 MYC MYC ECT2 ECT2 XRRA1 XRRA1 ANXA1 ANXA1 PTPRC PTPRC NABP1 NABP1 MFSD11 MFSD11 RAD51AP1 RAD51AP1 ABCG5 ABCG5 BLM BLM KARS1 KARS1 TP53BP1 TP53BP1 K7FQ62_PELSI K7FQ62_PELSI TOPBP1 TOPBP1 SPIDR SPIDR MAP3K20 MAP3K20 BARD1 BARD1 ERCC6 ERCC6 INO80 INO80 BABAM1 BABAM1 XRCC5 XRCC5 PRKAA1 PRKAA1 BAK1 BAK1 WRN WRN TP53 TP53 BRCC3 BRCC3 TICRR TICRR RAD51 RAD51 SFRP2 SFRP2 LIG4 LIG4 RAD54B RAD54B ERCC8 ERCC8 STK11 STK11 ITGB6 ITGB6 NIPBL NIPBL KDM1A KDM1A NUCKS1 NUCKS1 NABP2 NABP2 RAD9B RAD9B RAD54L RAD54L BCL2 BCL2 MEN1 MEN1 LZIC LZIC BABAM2 BABAM2 TANK TANK POLB POLB K7FC61_PELSI K7FC61_PELSI INIP INIP RFWD3 RFWD3 SIRT1 SIRT1 ATM ATM BRAT1 BRAT1 XRCC2 XRCC2 BRCA2 BRCA2 TIGAR TIGAR RAD1 RAD1 INTS7 INTS7 COP1 COP1 DCUN1D3 DCUN1D3 NET1 NET1 IKBIP IKBIP FANCD2 FANCD2 RNF8 RNF8 FBXO4 FBXO4 RAD9A RAD9A ATR ATR CDCA7 CDCA7 EYA3 EYA3 LOC102445415 LOC102445415 CHEK2 CHEK2 XRCC4 XRCC4 MSH2 MSH2 RNF168 RNF168 ABRAXAS1 ABRAXAS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM109Transmembrane protein 109. (238 aa)
XRCC6Uncharacterized protein. (321 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (275 aa)
MYCMYC proto-oncogene, bHLH transcription factor. (324 aa)
ECT2Epithelial cell transforming 2. (963 aa)
XRRA1X-ray radiation resistance associated 1. (743 aa)
ANXA1Annexin. (342 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (736 aa)
NABP1Nucleic acid binding protein 1. (213 aa)
MFSD11Major facilitator superfamily domain containing 11. (400 aa)
RAD51AP1RAD51 associated protein 1. (338 aa)
ABCG5ATP binding cassette subfamily G member 5. (606 aa)
BLMATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (557 aa)
KARS1Lysine--tRNA ligase. (581 aa)
TP53BP1Tumor protein p53 binding protein 1. (1831 aa)
K7FQ62_PELSIUncharacterized protein. (809 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1517 aa)
SPIDRScaffold protein involved in DNA repair. (550 aa)
MAP3K20Uncharacterized protein. (796 aa)
BARD1BRCA1 associated RING domain 1. (691 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1273 aa)
INO80INO80 complex ATPase subunit. (1561 aa)
BABAM1Uncharacterized protein. (224 aa)
XRCC5X-ray repair cross complementing 5. (742 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
BAK1BCL2 antagonist/killer 1. (213 aa)
WRNWRN RecQ like helicase. (1490 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (207 aa)
TICRRTOPBP1 interacting checkpoint and replication regulator. (1784 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SFRP2Secreted frizzled related protein 2. (150 aa)
LIG4DNA ligase. (912 aa)
RAD54BUncharacterized protein. (918 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (373 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
NIPBLNipped-B protein. (2788 aa)
KDM1ALysine demethylase 1A. (1099 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (203 aa)
NABP2Nucleic acid binding protein 2. (213 aa)
RAD9BUncharacterized protein. (141 aa)
RAD54LRAD54 like. (735 aa)
BCL2BCL2 apoptosis regulator. (232 aa)
MEN1Menin 1. (605 aa)
LZICLeucine zipper and CTNNBIP1 domain containing. (190 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
TANKTRAF family member associated NFKB activator. (427 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (319 aa)
K7FC61_PELSIBRCT_assoc domain-containing protein. (1048 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
RFWD3Ring finger and WD repeat domain 3. (759 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
ATMNon-specific serine/threonine protein kinase. (3061 aa)
BRAT1BRCA1 associated ATM activator 1. (838 aa)
XRCC2X-ray repair cross complementing 2. (299 aa)
BRCA2BRCA2 DNA repair associated. (3083 aa)
TIGARUncharacterized protein. (274 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
INTS7Integrator complex subunit 7. (960 aa)
COP1COP1 E3 ubiquitin ligase. (586 aa)
DCUN1D3DCN1-like protein. (304 aa)
NET1Neuroepithelial cell transforming 1. (555 aa)
IKBIPIKBKB interacting protein. (389 aa)
FANCD2FA complementation group D2. (1203 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (494 aa)
FBXO4F-box protein 4. (375 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa)
CDCA7Cell division cycle associated 7. (274 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (575 aa)
LOC102445415SAP domain-containing protein. (257 aa)
CHEK2Checkpoint kinase 2. (440 aa)
XRCC4X-ray repair cross complementing 4. (336 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (866 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (616 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (382 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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