(47 nodes) Negative regulation of autophagy network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTMR9	Myotubularin related protein 9. (550 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
	WDR6	WD_REPEATS_REGION domain-containing protein. (564 aa)
	KLHL22	BTB domain-containing protein. (638 aa)
	PINK1	PTEN induced kinase 1. (364 aa)
	TMEM39B	Transmembrane protein 39B. (493 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3388 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (128 aa)
	CTSA	Carboxypeptidase; Belongs to the peptidase S10 family. (383 aa)
	IL10	Interleukin 10. (161 aa)
	BCL2	BCL2 apoptosis regulator. (232 aa)
	RNF41	Ring finger protein 41. (316 aa)
	CPTP	Ceramide-1-phosphate transfer protein. (214 aa)
	CLEC16A	FPL domain-containing protein. (593 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (433 aa)
	RUBCN	RUN domain-containing protein. (620 aa)
	K7F2N5_PELSI	DUF4206 domain-containing protein. (233 aa)
	DAP	Uncharacterized protein. (87 aa)
	IL10RA	Interfer-bind domain-containing protein. (647 aa)
	K7F8W3_PELSI	SMG1_N domain-containing protein. (180 aa)
	BMF	Bcl2 modifying factor. (193 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (392 aa)
	LEPR	Leptin receptor. (1150 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (338 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (932 aa)
	K7GG98_PELSI	Uncharacterized protein. (438 aa)
	STAT3	Signal transducer and activator of transcription. (707 aa)
	ADRA1A	Adrenoceptor alpha 1A. (467 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (292 aa)
	K7G131_PELSI	Myotubularin phosphatase domain-containing protein. (524 aa)
	UBQLN4	Ubiquilin 4. (566 aa)
	SLC7A5	Solute carrier family 7 member 5. (428 aa)
	TSC2	TSC complex subunit 2. (1816 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
	TSPO2	Translocator protein 2. (164 aa)
	TSPO	Translocator protein. (164 aa)
	K7G6G8_PELSI	Uncharacterized protein. (175 aa)
	LZTS1	Leucine zipper tumor suppressor 1. (617 aa)
	PHF23	PHD finger protein 23. (347 aa)
	TMEM39A	Transmembrane protein 39A. (488 aa)
	FOXK2	Forkhead box K2. (533 aa)
	TIGAR	Uncharacterized protein. (274 aa)
	SCFD1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	LRRK2	Leucine rich repeat kinase 2. (2537 aa)
	TSC1	TSC complex subunit 1. (1168 aa)
	FOXK1	Forkhead box K1. (541 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	BMF	ENSPSIP00000003443	ENSPSIP00000010782	BCL2 apoptosis regulator.	Bcl2 modifying factor.	0.849
BCL2	IL10	ENSPSIP00000003443	ENSPSIP00000003748	BCL2 apoptosis regulator.	Interleukin 10.	0.428
BCL2	PINK1	ENSPSIP00000003443	ENSPSIP00000005635	BCL2 apoptosis regulator.	PTEN induced kinase 1.	0.400
BCL2	STAT3	ENSPSIP00000003443	ENSPSIP00000018063	BCL2 apoptosis regulator.	Signal transducer and activator of transcription.	0.697
BCL2	TP53	ENSPSIP00000003443	ENSPSIP00000014905	BCL2 apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.901
BMF	BCL2	ENSPSIP00000010782	ENSPSIP00000003443	Bcl2 modifying factor.	BCL2 apoptosis regulator.	0.849
CLEC16A	K7GG98_PELSI	ENSPSIP00000002663	ENSPSIP00000019309	FPL domain-containing protein.	Uncharacterized protein.	0.917
CLEC16A	RNF41	ENSPSIP00000002663	ENSPSIP00000003315	FPL domain-containing protein.	Ring finger protein 41.	0.425
IL10	BCL2	ENSPSIP00000003748	ENSPSIP00000003443	Interleukin 10.	BCL2 apoptosis regulator.	0.428
IL10	IL10RA	ENSPSIP00000003748	ENSPSIP00000002108	Interleukin 10.	Interfer-bind domain-containing protein.	0.995
IL10	STAT3	ENSPSIP00000003748	ENSPSIP00000018063	Interleukin 10.	Signal transducer and activator of transcription.	0.723
IL10RA	IL10	ENSPSIP00000002108	ENSPSIP00000003748	Interfer-bind domain-containing protein.	Interleukin 10.	0.995
IL10RA	STAT3	ENSPSIP00000002108	ENSPSIP00000018063	Interfer-bind domain-containing protein.	Signal transducer and activator of transcription.	0.791
K7F2N5_PELSI	RUBCN	ENSPSIP00000002295	ENSPSIP00000002307	DUF4206 domain-containing protein.	RUN domain-containing protein.	0.921
K7F8W3_PELSI	SMG1	ENSPSIP00000004473	ENSPSIP00000004872	SMG1_N domain-containing protein.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.920
K7F8W3_PELSI	TSC1	ENSPSIP00000004473	ENSPSIP00000011446	SMG1_N domain-containing protein.	TSC complex subunit 1.	0.597
K7F8W3_PELSI	TSC2	ENSPSIP00000004473	ENSPSIP00000014730	SMG1_N domain-containing protein.	TSC complex subunit 2.	0.691
K7GG98_PELSI	CLEC16A	ENSPSIP00000019309	ENSPSIP00000002663	Uncharacterized protein.	FPL domain-containing protein.	0.917
K7GG98_PELSI	RNF41	ENSPSIP00000019309	ENSPSIP00000003315	Uncharacterized protein.	Ring finger protein 41.	0.425
LEPR	STAT3	ENSPSIP00000010143	ENSPSIP00000018063	Leptin receptor.	Signal transducer and activator of transcription.	0.618