(40 nodes) Positive regulation of phosphatidylinositol 3-kinase signaling network (Pelodiscus sinensis)

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Known Interactions

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Predicted Interactions

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Your Input:
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (611 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	MYDGF	Myeloid derived growth factor. (165 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (531 aa)
	LOC102462376	Uncharacterized protein; Belongs to the semaphorin family. (720 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	LOC102446651	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1328 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
	PDGFC	Platelet derived growth factor C. (345 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (895 aa)
	LOC102443854	SERPIN domain-containing protein; Belongs to the serpin family. (411 aa)
	PRR5L	Proline rich 5 like. (366 aa)
	CSF3	Colony stimulating factor 3. (200 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (629 aa)
	NCF1	Neutrophil cytosolic factor 1. (390 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (245 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (857 aa)
	NTRK3	Neurotrophic receptor tyrosine kinase 3. (505 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (666 aa)
	NTRK1	Tyrosine-protein kinase receptor. (732 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (882 aa)
	FN1	Fibronectin 1. (2389 aa)
	PRR5	Proline rich 5. (404 aa)
	UNC5B	Unc-5 netrin receptor B. (944 aa)
	IL18	Interleukin 18. (200 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (476 aa)
	NKX3-1	NK3 homeobox 1. (212 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (757 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (356 aa)
	NTRK2	Tyrosine-protein kinase receptor. (814 aa)
	RELN	Uncharacterized protein. (2100 aa)
	K7F7A9_PELSI	Uncharacterized protein. (1108 aa)
	K7F7G4_PELSI	Reelin domain-containing protein. (177 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (607 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	F2	ENSPSIP00000019482	ENSPSIP00000005404	Angiotensinogen; Belongs to the serpin family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.671
AGT	GPER1	ENSPSIP00000019482	ENSPSIP00000001724	Angiotensinogen; Belongs to the serpin family.	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.641
DCN	FN1	ENSPSIP00000003676	ENSPSIP00000018267	Decorin; May affect the rate of fibrils formation.	Fibronectin 1.	0.496
DCN	ROR1	ENSPSIP00000003676	ENSPSIP00000011325	Decorin; May affect the rate of fibrils formation.	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.538
DCN	TGFB2	ENSPSIP00000003676	ENSPSIP00000009346	Decorin; May affect the rate of fibrils formation.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.940
F2	AGT	ENSPSIP00000005404	ENSPSIP00000019482	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Angiotensinogen; Belongs to the serpin family.	0.671
F2	LOC102443854	ENSPSIP00000005404	ENSPSIP00000011781	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.545
FLT1	IGF1	ENSPSIP00000014623	ENSPSIP00000014773	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Insulin like growth factor 1.	0.650
FLT1	PDGFB	ENSPSIP00000014623	ENSPSIP00000013168	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.881
FLT1	PDGFC	ENSPSIP00000014623	ENSPSIP00000010976	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Platelet derived growth factor C.	0.545
FN1	DCN	ENSPSIP00000018267	ENSPSIP00000003676	Fibronectin 1.	Decorin; May affect the rate of fibrils formation.	0.496
GPER1	AGT	ENSPSIP00000001724	ENSPSIP00000019482	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family.	Angiotensinogen; Belongs to the serpin family.	0.641
IGF1	FLT1	ENSPSIP00000014773	ENSPSIP00000014623	Insulin like growth factor 1.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.650
IGF1	KDR	ENSPSIP00000014773	ENSPSIP00000010744	Insulin like growth factor 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.650
IGF1	LOC102446651	ENSPSIP00000014773	ENSPSIP00000009561	Insulin like growth factor 1.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.650
IGF1	NTRK1	ENSPSIP00000014773	ENSPSIP00000017660	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.663
IGF1	NTRK2	ENSPSIP00000014773	ENSPSIP00000003723	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.663
IGF1	PDGFB	ENSPSIP00000014773	ENSPSIP00000013168	Insulin like growth factor 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.900
IGF1	TEK	ENSPSIP00000014773	ENSPSIP00000013526	Insulin like growth factor 1.	TEK receptor tyrosine kinase.	0.650
K7F7A9_PELSI	K7F7G4_PELSI	ENSPSIP00000003919	ENSPSIP00000003974	Uncharacterized protein.	Reelin domain-containing protein.	0.928