(113 nodes) Negative regulation of translation network (Pelodiscus sinensis)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC102445201	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (142 aa)
	SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein. (544 aa)
	TPR	Translocated promoter region, nuclear basket protein. (1848 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (130 aa)
	DHX36	DEAH-box helicase 36. (908 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (702 aa)
	K7G255_PELSI	PH domain-containing protein. (371 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (586 aa)
	RIDA	Reactive intermediate imine deaminase A homolog. (108 aa)
	PUS7	Pseudouridine synthase 7. (647 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (861 aa)
	EIF4EBP2	Eukaryotic translation initiation factor 4E binding protein 2. (117 aa)
	TRIM71	Tripartite motif containing 71. (575 aa)
	CNOT10	CCR4-NOT transcription complex subunit 10. (748 aa)
	PDE12	Phosphodiesterase 12. (615 aa)
	TNRC6B	Trinucleotide repeat containing adaptor 6B. (1768 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2376 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (561 aa)
	EXOSC3	Exosome component 3. (168 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (767 aa)
	DDX6	DEAD-box helicase 6; Belongs to the DEAD box helicase family. (486 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2 alpha kinase 1. (546 aa)
	ENC1	Ectodermal-neural cortex 1. (382 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (109 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (861 aa)
	MALSU1	Mitochondrial assembly of ribosomal large subunit 1. (151 aa)
	DCP2	Decapping mRNA 2. (421 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (463 aa)
	DCPS	Decapping enzyme, scavenger. (267 aa)
	METTL16	U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (518 aa)
	SRP9	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
	PAIP2	Poly(A) binding protein interacting protein 2. (124 aa)
	PARN	Poly(A)-specific ribonuclease. (640 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (524 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (584 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (488 aa)
	EXOSC9	Exosome component 9. (385 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1127 aa)
	PATL1	PAT1 homolog 1, processing body mRNA decay factor. (804 aa)
	CAPRIN2	Caprin family member 2. (1229 aa)
	CNOT6L	CCR4-NOT transcription complex subunit 6 like. (555 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (365 aa)
	PCIF1	PDX1 C-terminal inhibiting factor 1. (708 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (584 aa)
	CPEB1	Uncharacterized protein. (335 aa)
	TUT4	Terminal uridylyl transferase 4. (1578 aa)
	K7GG71_PELSI	Tis11B_N domain-containing protein. (113 aa)
	CNOT6	CCR4-NOT transcription complex subunit 6. (544 aa)
	CNOT11	CCR4-NOT transcription complex subunit 11. (322 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (838 aa)
	PATL2	PAT1 homolog 2. (553 aa)
	EIF4ENIF1	Uncharacterized protein. (978 aa)
	EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2. (569 aa)
	XRN1	5'-3' exoribonuclease 1. (1747 aa)
	TNRC6C	Trinucleotide repeat containing adaptor 6C. (1721 aa)
	RPL13A	Ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. (198 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3. (279 aa)
	TNRC6A	Trinucleotide repeat containing adaptor 6A. (1414 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (186 aa)
	TUT7	Terminal uridylyl transferase 7. (1538 aa)
	CNOT3	Not3 domain-containing protein. (184 aa)
	DCP1A	Decapping mRNA 1A. (611 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1196 aa)
	HNRNPR	Heterogeneous nuclear ribonucleoprotein R. (629 aa)
	POLR2D	RNA polymerase II subunit D. (118 aa)
	EXOSC8	Exosome component 8. (274 aa)
	LOC102459574	BTB domain-containing protein. (582 aa)
	ANG	Angiogenin; Belongs to the pancreatic ribonuclease family. (161 aa)
	K7EX97_PELSI	Nanos-type domain-containing protein; Belongs to the nanos family. (82 aa)
	LOC102450726	Uncharacterized protein. (937 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (532 aa)
	SAMD4B	Sterile alpha motif domain containing 4B. (681 aa)
	EXOSC2	Exosome component 2. (294 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (132 aa)
	SAMD4A	Sterile alpha motif domain containing 4A. (681 aa)
	AGO3	Argonaute RISC catalytic component 3; Belongs to the argonaute family. (822 aa)
	FTO	FTO alpha-ketoglutarate dependent dioxygenase. (509 aa)
	DIS3L2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (864 aa)
	METTL14	Methyltransferase like 14; Belongs to the MT-A70-like family. (459 aa)
	FXR1	FMR1 autosomal homolog 1. (672 aa)
	CAPRIN1	Cell cycle associated protein 1. (705 aa)
	MRPL13	Mitochondrial ribosomal protein L13. (170 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (335 aa)
	FXR2	FMR1 autosomal homolog 2. (644 aa)
	ILF3	Interleukin enhancer binding factor 3. (881 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1358 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	RNF139	Ring finger protein 139. (660 aa)
	FMR1	Fragile X mental retardation 1. (561 aa)
	CPEB2	Cytoplasmic polyadenylation element binding protein 2. (525 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (573 aa)
	DCP1B	Decapping mRNA 1B. (609 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (728 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
	UPF1	UPF1 RNA helicase and ATPase. (758 aa)
	IREB2	Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (880 aa)
	NOCT	Nocturnin. (495 aa)
	TSC1	TSC complex subunit 1. (1168 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (654 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
	EPRS1	Glutamyl-prolyl-tRNA synthetase. (1624 aa)
	YBX1	Y-box binding protein 1. (275 aa)
	PAIP2B	Poly(A) binding protein interacting protein 2B. (126 aa)
	PNLDC1	PARN like, ribonuclease domain containing 1. (298 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (212 aa)
	LRRC27	Leucine rich repeat containing 27. (465 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1240 aa)
	EXOSC7	Exosome component 7. (272 aa)
	SESN2	Uncharacterized protein. (443 aa)
	MLH1	MutL homolog 1. (727 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSPSIP00000019796	ENSPSIP00000004340	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.864
AGO1	DCP2	ENSPSIP00000019796	ENSPSIP00000015916	Argonaute RISC component 1; Belongs to the argonaute family.	Decapping mRNA 2.	0.536
AGO1	DDX6	ENSPSIP00000019796	ENSPSIP00000014886	Argonaute RISC component 1; Belongs to the argonaute family.	DEAD-box helicase 6; Belongs to the DEAD box helicase family.	0.710
AGO1	FMR1	ENSPSIP00000019796	ENSPSIP00000010080	Argonaute RISC component 1; Belongs to the argonaute family.	Fragile X mental retardation 1.	0.438
AGO1	FXR1	ENSPSIP00000019796	ENSPSIP00000008435	Argonaute RISC component 1; Belongs to the argonaute family.	FMR1 autosomal homolog 1.	0.402
AGO1	FXR2	ENSPSIP00000019796	ENSPSIP00000009051	Argonaute RISC component 1; Belongs to the argonaute family.	FMR1 autosomal homolog 2.	0.402
AGO1	TNRC6A	ENSPSIP00000019796	ENSPSIP00000004207	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6A.	0.859
AGO1	TNRC6B	ENSPSIP00000019796	ENSPSIP00000005719	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6B.	0.539
AGO1	TNRC6C	ENSPSIP00000019796	ENSPSIP00000020415	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6C.	0.853
AGO2	AGO1	ENSPSIP00000004340	ENSPSIP00000019796	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.864
AGO2	AGO3	ENSPSIP00000004340	ENSPSIP00000008050	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	0.864
AGO2	AGO4	ENSPSIP00000004340	ENSPSIP00000015810	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.	0.864
AGO2	CNOT1	ENSPSIP00000004340	ENSPSIP00000005927	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 1.	0.460
AGO2	DCP2	ENSPSIP00000004340	ENSPSIP00000015916	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Decapping mRNA 2.	0.597
AGO2	DDX6	ENSPSIP00000004340	ENSPSIP00000014886	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DEAD-box helicase 6; Belongs to the DEAD box helicase family.	0.902
AGO2	FMR1	ENSPSIP00000004340	ENSPSIP00000010080	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Fragile X mental retardation 1.	0.746
AGO2	FXR1	ENSPSIP00000004340	ENSPSIP00000008435	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	FMR1 autosomal homolog 1.	0.525
AGO2	FXR2	ENSPSIP00000004340	ENSPSIP00000009051	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	FMR1 autosomal homolog 2.	0.525
AGO2	POLR2D	ENSPSIP00000004340	ENSPSIP00000002968	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RNA polymerase II subunit D.	0.523
AGO2	RC3H2	ENSPSIP00000004340	ENSPSIP00000005812	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ring finger and CCCH-type domains 2.	0.401