STRINGSTRING
LRRK2 LRRK2 MASTL MASTL PIKFYVE PIKFYVE SMG1 SMG1 PRKX PRKX K7FA56_PELSI K7FA56_PELSI DYRK1B DYRK1B NEK6 NEK6 AKT3 AKT3 PINK1 PINK1 TGFBR2 TGFBR2 IKBKB IKBKB SMTNL1 SMTNL1 STK38L STK38L CLSPN CLSPN TNKS TNKS NTRK2 NTRK2 IKBKE IKBKE DYRK3 DYRK3 MAPKAPK2 MAPKAPK2 IL20 IL20 K7F6U7_PELSI K7F6U7_PELSI LOC102457599 LOC102457599 PRKAA2 PRKAA2 HIPK1 HIPK1 SGK1 SGK1 K7F7W2_PELSI K7F7W2_PELSI LOC102445801 LOC102445801 K7F8W3_PELSI K7F8W3_PELSI PRKCB PRKCB CSNK2A2 CSNK2A2 RPS6KA5 RPS6KA5 MYO3A MYO3A DGKQ DGKQ GAS6 GAS6 ULK1 ULK1 GSK3B GSK3B PKN1 PKN1 DYRK4 DYRK4 PRKCQ PRKCQ RPS6KA3 RPS6KA3 K7FRX4_PELSI K7FRX4_PELSI TTK TTK CSNK1G1 CSNK1G1 STK32A STK32A RICTOR RICTOR EIF2AK3 EIF2AK3 K7FUU4_PELSI K7FUU4_PELSI ROCK2 ROCK2 RIPK1 RIPK1 DCLK1-2 DCLK1-2 HIPK3 HIPK3 CAMK4 CAMK4 SYK SYK MAST1 MAST1 CSNK1A1 CSNK1A1 K7FZ97_PELSI K7FZ97_PELSI STK32C STK32C MAST4 MAST4 PRKCH PRKCH PDGFB PDGFB VRK3 VRK3 NEK7 NEK7 MAST2 MAST2 PRKCE PRKCE CSNK1D CSNK1D DYRK1A DYRK1A PDPK1 PDPK1 PRKAA1 PRKAA1 NLK NLK AURKA AURKA UHMK1 UHMK1 CSNK1G3 CSNK1G3 TECPR1 TECPR1 LOC102451406 LOC102451406 BRSK2 BRSK2 MKNK2 MKNK2 MORC3 MORC3 KIAA1549 KIAA1549 RPS6KB2 RPS6KB2 PRKCG PRKCG CDK1 CDK1 CAMK1D CAMK1D MAPK9 MAPK9 ULK2 ULK2 MAPKAPK3 MAPKAPK3 CHEK2 CHEK2 PRKCA PRKCA CUNH19orf12 CUNH19orf12 SGK2 SGK2 STK32B STK32B DYRK2 DYRK2 TTBK1 TTBK1 LATS1 LATS1 ULK3 ULK3 PRKCD PRKCD PRKDC PRKDC PBK PBK MAP3K13 MAP3K13 RPS6KA1 RPS6KA1 CSNK2A1 CSNK2A1 RPS6KA4 RPS6KA4 ATR ATR TGFBR1 TGFBR1 PKN3 PKN3 CAMKV CAMKV ATM ATM CHUK CHUK PLK1 PLK1 PAK2 PAK2 LOC102456451 LOC102456451 LOC102456698 LOC102456698 MAST3 MAST3 MYO3B MYO3B PKN2 PKN2 TLK1 TLK1 CDC7 CDC7 STK38 STK38 MAPKAPK5 MAPKAPK5 LOC102459794 LOC102459794 RPS6KA2 RPS6KA2 MKNK1 MKNK1 MAPK1 MAPK1 BCL2 BCL2 MAPK7 MAPK7 AURKB AURKB RPS6KA6 RPS6KA6 K7FGV8_PELSI K7FGV8_PELSI PDK3 PDK3 MAPK13 MAPK13 LATS2 LATS2 TBK1 TBK1 TOP1 TOP1 PKD1 PKD1 MTOR MTOR PRKCZ PRKCZ AKT1 AKT1 RPS6KB1 RPS6KB1 K7FKZ4_PELSI K7FKZ4_PELSI ILK ILK ROCK1 ROCK1 TTBK2 TTBK2 MAPK12 MAPK12 BAK1 BAK1 SGK3 SGK3 VRK2 VRK2 VRK1 VRK1 PRKCI PRKCI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRK2Leucine rich repeat kinase 2. (2537 aa)
MASTLMicrotubule associated serine/threonine kinase like. (908 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (1498 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3388 aa)
PRKXUncharacterized protein. (289 aa)
K7FA56_PELSIUncharacterized protein. (4129 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (416 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (314 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PINK1PTEN induced kinase 1. (364 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (584 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (714 aa)
SMTNL1Calponin-homology (CH) domain-containing protein. (488 aa)
STK38LNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (464 aa)
CLSPNClaspin. (1345 aa)
TNKSPoly [ADP-ribose] polymerase. (1133 aa)
NTRK2Tyrosine-protein kinase receptor. (814 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (728 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (579 aa)
MAPKAPK2MAPK activated protein kinase 2. (307 aa)
IL20Interleukin 20. (175 aa)
K7F6U7_PELSIUncharacterized protein. (151 aa)
LOC102457599TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
K7F7W2_PELSIUncharacterized protein. (97 aa)
LOC102445801Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
K7F8W3_PELSISMG1_N domain-containing protein. (180 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (600 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (340 aa)
RPS6KA5Ribosomal protein S6 kinase. (833 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1315 aa)
DGKQDiacylglycerol kinase. (853 aa)
GAS6Growth arrest specific 6. (403 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1030 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (419 aa)
PKN1Protein kinase domain-containing protein. (812 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (357 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (708 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
K7FRX4_PELSIProtein kinase domain-containing protein. (267 aa)
TTKTTK protein kinase. (881 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (459 aa)
STK32ASerine/threonine kinase 32A; Belongs to the protein kinase superfamily. (378 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1715 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
K7FUU4_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (191 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (716 aa)
DCLK1-2Protein kinase domain-containing protein. (502 aa)
HIPK3Homeodomain interacting protein kinase 3. (1193 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (357 aa)
SYKTyrosine-protein kinase. (445 aa)
MAST1Microtubule associated serine/threonine kinase 1. (992 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (364 aa)
K7FZ97_PELSIUncharacterized protein. (93 aa)
STK32CSerine/threonine kinase 32C; Belongs to the protein kinase superfamily. (426 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2424 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (245 aa)
VRK3VRK serine/threonine kinase 3. (445 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1894 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
CSNK1DCasein kinase 1 delta. (426 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (559 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (409 aa)
UHMK1U2AF homology motif kinase 1. (329 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (456 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (874 aa)
LOC102451406Uncharacterized protein. (132 aa)
BRSK2BR serine/threonine kinase 2. (599 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (467 aa)
MORC3MORC family CW-type zinc finger 3. (935 aa)
KIAA1549KIAA1549. (1683 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (450 aa)
PRKCGProtein kinase C gamma. (476 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (296 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1015 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (387 aa)
CHEK2Checkpoint kinase 2. (440 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
CUNH19orf12Uncharacterized protein. (268 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (368 aa)
STK32BSerine/threonine kinase 32B; Belongs to the protein kinase superfamily. (422 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (598 aa)
TTBK1Tau tubulin kinase 1. (1262 aa)
LATS1Large tumor suppressor kinase 1. (970 aa)
ULK3Unc-51 like kinase 3. (439 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (696 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4133 aa)
PBKPDZ binding kinase. (322 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase. (873 aa)
RPS6KA1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (744 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
RPS6KA4Ribosomal protein S6 kinase. (752 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
PKN3Uncharacterized protein. (926 aa)
CAMKVCaM kinase like vesicle associated. (243 aa)
ATMNon-specific serine/threonine protein kinase. (3061 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (716 aa)
PLK1Polo like kinase 1. (418 aa)
PAK2Non-specific serine/threonine protein kinase. (520 aa)
LOC102456451Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (271 aa)
LOC102456698Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (271 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1304 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1125 aa)
PKN2Protein kinase N2. (946 aa)
TLK1Tousled like kinase 1. (631 aa)
CDC7Cell division cycle 7. (569 aa)
STK38Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa)
MAPKAPK5Protein kinase domain-containing protein. (405 aa)
LOC102459794Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (347 aa)
RPS6KA2Ribosomal protein S6 kinase. (734 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
MAPK1Mitogen-activated protein kinase. (322 aa)
BCL2BCL2 apoptosis regulator. (232 aa)
MAPK7Mitogen-activated protein kinase 7. (762 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (365 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (714 aa)
K7FGV8_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (336 aa)
PDK3Protein-serine/threonine kinase. (413 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
LATS2Non-specific serine/threonine protein kinase. (1125 aa)
TBK1TANK binding kinase 1. (728 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (766 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4156 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
K7FKZ4_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (386 aa)
ILKIntegrin linked kinase. (311 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1358 aa)
TTBK2Tau tubulin kinase 2. (1336 aa)
MAPK12Mitogen-activated protein kinase. (364 aa)
BAK1BCL2 antagonist/killer 1. (213 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
VRK2VRK serine/threonine kinase 2. (493 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (412 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (607 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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