(26 nodes) Regulation of vasoconstriction network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	K7FLE1_PELSI	PDZ domain-containing protein. (116 aa)
	ADRA1B	Adrenoceptor alpha 1B. (509 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
	EDN2	Endothelin 2. (67 aa)
	ADRA1A	Adrenoceptor alpha 1A. (467 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
	SMTNL2	Calponin-homology (CH) domain-containing protein. (337 aa)
	ZDHHC21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	AVPR1A	Arginine vasopressin receptor 1A. (422 aa)
	ADRA1D	Adrenoceptor alpha 1D. (498 aa)
	DBH	Dopamine beta-hydroxylase. (632 aa)
	FGB	Fibrinogen beta chain. (487 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (2013 aa)
	LOC102460028	G_PROTEIN_RECEP_F1_2 domain-containing protein. (371 aa)
	FGG	Fibrinogen gamma chain. (435 aa)
	OXTR	Oxytocin receptor. (389 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	K7FFB5_PELSI	END domain-containing protein. (82 aa)
	SMTNL1	Calponin-homology (CH) domain-containing protein. (488 aa)
	EDN1	Endothelin 1. (204 aa)
	AVPR1B	Arginine vasopressin receptor 1B. (405 aa)
	TBXA2R	Thromboxane A2 receptor. (284 aa)
	ADRA2B	Adrenoceptor alpha 2B. (420 aa)
	ADRA2C	Adrenoceptor alpha 2C. (413 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	ADRA2A	Adrenoceptor alpha 2A. (446 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	ADRA1B	ENSPSIP00000018062	ENSPSIP00000020319	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1B.	0.938
ADRA1A	ADRA1D	ENSPSIP00000018062	ENSPSIP00000010999	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1D.	0.937
ADRA1A	EDN1	ENSPSIP00000018062	ENSPSIP00000004800	Adrenoceptor alpha 1A.	Endothelin 1.	0.632
ADRA1A	EDN2	ENSPSIP00000018062	ENSPSIP00000019576	Adrenoceptor alpha 1A.	Endothelin 2.	0.577
ADRA1A	K7FFB5_PELSI	ENSPSIP00000018062	ENSPSIP00000006725	Adrenoceptor alpha 1A.	END domain-containing protein.	0.631
ADRA1A	TBXA2R	ENSPSIP00000018062	ENSPSIP00000001718	Adrenoceptor alpha 1A.	Thromboxane A2 receptor.	0.470
ADRA1B	ADRA1A	ENSPSIP00000020319	ENSPSIP00000018062	Adrenoceptor alpha 1B.	Adrenoceptor alpha 1A.	0.938
ADRA1B	ADRA1D	ENSPSIP00000020319	ENSPSIP00000010999	Adrenoceptor alpha 1B.	Adrenoceptor alpha 1D.	0.900
ADRA1B	EDN1	ENSPSIP00000020319	ENSPSIP00000004800	Adrenoceptor alpha 1B.	Endothelin 1.	0.543
ADRA1B	K7FFB5_PELSI	ENSPSIP00000020319	ENSPSIP00000006725	Adrenoceptor alpha 1B.	END domain-containing protein.	0.438
ADRA1B	TBXA2R	ENSPSIP00000020319	ENSPSIP00000001718	Adrenoceptor alpha 1B.	Thromboxane A2 receptor.	0.411
ADRA1D	ADRA1A	ENSPSIP00000010999	ENSPSIP00000018062	Adrenoceptor alpha 1D.	Adrenoceptor alpha 1A.	0.937
ADRA1D	ADRA1B	ENSPSIP00000010999	ENSPSIP00000020319	Adrenoceptor alpha 1D.	Adrenoceptor alpha 1B.	0.900
ADRA1D	EDN1	ENSPSIP00000010999	ENSPSIP00000004800	Adrenoceptor alpha 1D.	Endothelin 1.	0.543
ADRA1D	K7FFB5_PELSI	ENSPSIP00000010999	ENSPSIP00000006725	Adrenoceptor alpha 1D.	END domain-containing protein.	0.438
ADRA1D	TBXA2R	ENSPSIP00000010999	ENSPSIP00000001718	Adrenoceptor alpha 1D.	Thromboxane A2 receptor.	0.411
ADRA2A	ADRA2B	ENSPSIP00000000345	ENSPSIP00000001027	Adrenoceptor alpha 2A.	Adrenoceptor alpha 2B.	0.401
ADRA2B	ADRA2A	ENSPSIP00000001027	ENSPSIP00000000345	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2A.	0.401
ADRA2B	ADRA2C	ENSPSIP00000001027	ENSPSIP00000000913	Adrenoceptor alpha 2B.	Adrenoceptor alpha 2C.	0.402
ADRA2C	ADRA2B	ENSPSIP00000000913	ENSPSIP00000001027	Adrenoceptor alpha 2C.	Adrenoceptor alpha 2B.	0.402