(87 nodes) Calcium-mediated signaling network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HPCA	Hippocalcin. (240 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (1261 aa)
	TMEM38B	Transmembrane protein 38B. (279 aa)
	CCL20	C-C motif chemokine. (100 aa)
	LOC102462453	Uncharacterized protein. (193 aa)
	EDN1	Endothelin 1. (204 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (388 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (773 aa)
	NCALD	Neurocalcin delta. (193 aa)
	NFATC3	Nuclear factor of activated T cells 3. (949 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1323 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	ACKR2	Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	PTGFR	Prostaglandin F receptor. (362 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	NMUR1	Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (809 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (433 aa)
	LOC102446119	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	CCR4	C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (175 aa)
	ACKR4	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	LOC102460373	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	K7EZ53_PELSI	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (333 aa)
	K7EZ43_PELSI	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (315 aa)
	LOC102452532	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	CXCR5	C-X-C motif chemokine receptor 5. (231 aa)
	TBC1D10C	TBC1 domain family member 10C. (457 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1115 aa)
	TRPM8	Transient receptor potential cation channel subfamily M member 8. (1091 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (500 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2752 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	LOC102453058	Uncharacterized protein. (771 aa)
	RCAN1	Regulator of calcineurin 1. (169 aa)
	ITPR2	Uncharacterized protein. (1419 aa)
	K7GHJ2_PELSI	Uncharacterized protein. (671 aa)
	K7GH32_PELSI	Uncharacterized protein. (130 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1114 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (501 aa)
	MCOLN2	Mucolipin 2. (543 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (731 aa)
	MCOLN3	Mucolipin 3. (553 aa)
	RCAN2	Regulator of calcineurin 2. (196 aa)
	K7GAP2_PELSI	Uncharacterized protein. (196 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
	RCAN3	RCAN family member 3. (249 aa)
	GRM1	Glutamate metabotropic receptor 1. (1203 aa)
	NFATC2	Nuclear factor of activated T cells 2. (901 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (560 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
	RYR2	Ryanodine receptor 2. (4872 aa)
	MCOLN1	Mucolipin 1. (578 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1500 aa)
	SYK	Tyrosine-protein kinase. (445 aa)
	TPCN2	Uncharacterized protein. (684 aa)
	ADGRL1	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1512 aa)
	RYR3	Ryanodine receptor 3. (4872 aa)
	LOC102449550	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	NFATC1	Nuclear factor of activated T cells 1. (932 aa)
	NFAT5	Nuclear factor of activated T cells 5. (1432 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	TPCN1	Two pore segment channel 1. (764 aa)
	LRRK2	Leucine rich repeat kinase 2. (2537 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (516 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (350 aa)
	PPP3R1	Uncharacterized protein. (161 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1028 aa)
	SAMD3	Sterile alpha motif domain containing 3. (524 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (961 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1411 aa)
	LOC102463966	Uncharacterized protein. (1286 aa)
	TRPM5	Transient receptor potential cation channel subfamily M member 5. (1114 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1328 aa)
	K7FPY4_PELSI	Uncharacterized protein. (156 aa)
	GPR143	Uncharacterized protein. (294 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	K7FNV3_PELSI	Phosphoinositide phospholipase C. (1177 aa)
	K7FNS9_PELSI	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1288 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (736 aa)
	DMTN	Dematin actin binding protein. (401 aa)
	HOMER2	Homer scaffold protein 2. (361 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (310 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR2	CCR7	ENSPSIP00000002765	ENSPSIP00000002562	Atypical chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.470
ACKR3	CXCR4	ENSPSIP00000020039	ENSPSIP00000009723	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.900
ACKR3	CXCR5	ENSPSIP00000020039	ENSPSIP00000000459	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 5.	0.504
ACKR3	LOC102452532	ENSPSIP00000020039	ENSPSIP00000001003	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.464
ADGRL1	LRRK2	ENSPSIP00000013433	ENSPSIP00000012179	Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.	Leucine rich repeat kinase 2.	0.675
AGTR1	EDN1	ENSPSIP00000000825	ENSPSIP00000004800	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.749
CASQ1	CASQ2	ENSPSIP00000004567	ENSPSIP00000016267	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.901
CASQ1	RYR2	ENSPSIP00000004567	ENSPSIP00000015323	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.933
CASQ1	RYR3	ENSPSIP00000004567	ENSPSIP00000013384	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 3.	0.933
CASQ2	CASQ1	ENSPSIP00000016267	ENSPSIP00000004567	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.901
CASQ2	RYR2	ENSPSIP00000016267	ENSPSIP00000015323	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.933
CASQ2	RYR3	ENSPSIP00000016267	ENSPSIP00000013384	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 3.	0.933
CCL20	CCR4	ENSPSIP00000005215	ENSPSIP00000001247	C-C motif chemokine.	C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.664
CCL20	CCR6	ENSPSIP00000005215	ENSPSIP00000001262	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.986
CCL20	CCR7	ENSPSIP00000005215	ENSPSIP00000002562	C-C motif chemokine.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.732
CCL20	CXCR4	ENSPSIP00000005215	ENSPSIP00000009723	C-C motif chemokine.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.621
CCL20	CXCR5	ENSPSIP00000005215	ENSPSIP00000000459	C-C motif chemokine.	C-X-C motif chemokine receptor 5.	0.621
CCL20	K7FNS9_PELSI	ENSPSIP00000005215	ENSPSIP00000009689	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.608
CCL20	LOC102446119	ENSPSIP00000005215	ENSPSIP00000001321	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.443
CCL20	LOC102452532	ENSPSIP00000005215	ENSPSIP00000001003	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.550