116 items (Pelodiscus sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HEATR5A	HEAT repeat containing 5A. (2046 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	LOC102453320	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (276 aa)
	TLR2	TIR domain-containing protein; Belongs to the Toll-like receptor family. (783 aa)
	LOC102457570	TIR domain-containing protein; Belongs to the Toll-like receptor family. (783 aa)
	SLC18A3	Solute carrier family 18 member A3. (509 aa)
	CDC42EP2	CDC42 effector protein 2. (237 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (222 aa)
	LMBRD1	LMBR1 domain containing 1. (540 aa)
	RAB5B	RAB5B, member RAS oncogene family. (217 aa)
	RIN1	Ras and Rab interactor 1. (568 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (877 aa)
	RAB7B	RAB7B, member RAS oncogene family. (200 aa)
	CDC42EP4	CDC42 effector protein 4. (330 aa)
	RAB14	RAB14, member RAS oncogene family. (215 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (716 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (1498 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	DPP4	Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
	K7FBX3_PELSI	Uncharacterized protein. (98 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (862 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1670 aa)
	GAPVD1	GTPase activating protein and VPS9 domains 1. (1461 aa)
	K7FCY5_PELSI	Uncharacterized protein. (161 aa)
	EHD1	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
	CD2AP	CD2 associated protein. (596 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1644 aa)
	LOC102463148	Uncharacterized protein. (178 aa)
	SH3KBP1	SH3 domain containing kinase binding protein 1. (613 aa)
	RAB8B	RAB8B, member RAS oncogene family. (183 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	RABGEF1	Uncharacterized protein. (578 aa)
	RIN3	Ras and Rab interactor 3. (973 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (122 aa)
	RABEP1	Rabaptin, RAB GTPase binding effector protein 1. (860 aa)
	SYT11	Synaptotagmin 11. (373 aa)
	RAB8A	RAB8A, member RAS oncogene family. (180 aa)
	STX8	Syntaxin 8. (228 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1. (760 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (242 aa)
	VPS9D1	VPS9 domain containing 1. (577 aa)
	K7FRF1_PELSI	Uncharacterized protein. (141 aa)
	SCARB2	Scavenger receptor class B member 2; Belongs to the CD36 family. (421 aa)
	FFAR4	Free fatty acid receptor 4. (352 aa)
	ZYX	Zyxin. (594 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	RAB15	RAB15, member RAS oncogene family. (178 aa)
	RAB11B	Uncharacterized protein. (257 aa)
	K7FTK9_PELSI	Uncharacterized protein. (223 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ATG14	Autophagy related 14. (393 aa)
	ANXA3	Annexin. (323 aa)
	RAB39A	RAB39A, member RAS oncogene family. (213 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (524 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
	UVRAG	UV radiation resistance associated. (659 aa)
	RAB11A	RAB11A, member RAS oncogene family. (236 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (950 aa)
	IGF2R	Insulin like growth factor 2 receptor. (2448 aa)
	RAB11FIP4	RAB11 family interacting protein 4. (496 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1284 aa)
	SYK	Tyrosine-protein kinase. (445 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (864 aa)
	TYRP1	Tyrosinase related protein 1. (535 aa)
	LOC102444442	Uncharacterized protein. (252 aa)
	TLR6	Toll-like receptor. (653 aa)
	K7G218_PELSI	TIR domain-containing protein; Belongs to the Toll-like receptor family. (1043 aa)
	K7G241_PELSI	Uncharacterized protein. (239 aa)
	ANXA11	Annexin. (509 aa)
	LOC102463951	Uncharacterized protein. (216 aa)
	VAMP8	Vesicle associated membrane protein 8. (103 aa)
	RILP	RH2 domain-containing protein. (69 aa)
	RIN2	Ras and Rab interactor 2. (891 aa)
	LAMP1	Lysosomal associated membrane protein 1. (397 aa)
	RAB32	RAB32, member RAS oncogene family. (218 aa)
	STX12	Syntaxin 12; Belongs to the syntaxin family. (265 aa)
	TIRAP	TIR domain containing adaptor protein. (232 aa)
	RAB11FIP5	RAB11 family interacting protein 5. (542 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (946 aa)
	STX7	Syntaxin 7; Belongs to the syntaxin family. (258 aa)
	AMN	Amnion associated transmembrane protein. (481 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1205 aa)
	LPAR2	Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (263 aa)
	RAB5C	Uncharacterized protein. (216 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (433 aa)
	SYT7	Synaptotagmin 7. (674 aa)
	RAB20	RAB20, member RAS oncogene family. (234 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	RAB38	RAB38, member RAS oncogene family. (212 aa)
	VPS26B	VPS26, retromer complex component B. (336 aa)
	VAMP3	Vesicle associated membrane protein 3. (98 aa)
	STXBP4	Syntaxin binding protein 4. (742 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (643 aa)
	TRIM14	Tripartite motif containing 14. (377 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (1101 aa)
	EHD4	EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (490 aa)
	RAB17	RAB17, member RAS oncogene family. (237 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (109 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (639 aa)
	DCT	Dopachrome tautomerase. (525 aa)
	ECPAS	Ecm29 proteasome adaptor and scaffold. (1688 aa)
	RAB35	Uncharacterized protein. (193 aa)
	LAMP2	Lysosomal associated membrane protein 2. (480 aa)
	STAM2	Signal transducing adaptor molecule 2. (473 aa)
	EHD3	EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
	K7GIL3_PELSI	Uncharacterized protein. (797 aa)
	RAB10	RAB10, member RAS oncogene family. (137 aa)
	HEATR5B	Uncharacterized protein. (1285 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG14	ENSPSIP00000007005	ENSPSIP00000012051	Autophagy and beclin 1 regulator 1.	Autophagy related 14.	0.800
AMBRA1	PIK3C3	ENSPSIP00000007005	ENSPSIP00000013847	Autophagy and beclin 1 regulator 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.852
AMBRA1	UVRAG	ENSPSIP00000007005	ENSPSIP00000013253	Autophagy and beclin 1 regulator 1.	UV radiation resistance associated.	0.669
AP2A2	AP2M1	ENSPSIP00000016265	ENSPSIP00000017064	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.998
AP2A2	AP2S1	ENSPSIP00000016265	ENSPSIP00000007963	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.998
AP2A2	CD2AP	ENSPSIP00000016265	ENSPSIP00000006537	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	CD2 associated protein.	0.435
AP2A2	CLTC	ENSPSIP00000016265	ENSPSIP00000010241	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.713
AP2A2	CLTCL1	ENSPSIP00000016265	ENSPSIP00000005552	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.713
AP2A2	SCARB2	ENSPSIP00000016265	ENSPSIP00000010778	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Scavenger receptor class B member 2; Belongs to the CD36 family.	0.539
AP2A2	SGIP1	ENSPSIP00000016265	ENSPSIP00000008765	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	SH3 domain GRB2 like endophilin interacting protein 1.	0.834
AP2A2	SH3KBP1	ENSPSIP00000016265	ENSPSIP00000006873	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	SH3 domain containing kinase binding protein 1.	0.435
AP2A2	SLC18A3	ENSPSIP00000016265	ENSPSIP00000000541	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Solute carrier family 18 member A3.	0.542
AP2A2	SYT11	ENSPSIP00000016265	ENSPSIP00000008555	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Synaptotagmin 11.	0.439
AP2A2	VAMP3	ENSPSIP00000016265	ENSPSIP00000017984	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Vesicle associated membrane protein 3.	0.508
AP2A2	VAMP8	ENSPSIP00000016265	ENSPSIP00000014943	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	Vesicle associated membrane protein 8.	0.429
AP2M1	AP2A2	ENSPSIP00000017064	ENSPSIP00000016265	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.998
AP2M1	AP2S1	ENSPSIP00000017064	ENSPSIP00000007963	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2M1	APPL1	ENSPSIP00000017064	ENSPSIP00000007726	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.490
AP2M1	APPL2	ENSPSIP00000017064	ENSPSIP00000018146	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.490
AP2M1	CLTC	ENSPSIP00000017064	ENSPSIP00000010241	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.885