(11 nodes) Thyroid gland development network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXD3	Homeobox D3. (414 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	HESX1	HESX homeobox 1. (197 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (760 aa)
	PAX8	Paired box 8. (321 aa)
	NKX2-5	NK2 homeobox 5. (272 aa)
	HOXA3	Homeobox A3. (411 aa)
	EDN1	Endothelin 1. (204 aa)
	TG	Thyroglobulin. (2775 aa)
	HOXA5	Homeobox A5. (264 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDNRA	ENSPSIP00000004800	ENSPSIP00000006983	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.998
EDN1	FGF8	ENSPSIP00000004800	ENSPSIP00000009052	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.544
EDN1	NKX2-5	ENSPSIP00000004800	ENSPSIP00000016815	Endothelin 1.	NK2 homeobox 5.	0.526
EDNRA	EDN1	ENSPSIP00000006983	ENSPSIP00000004800	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
FGF8	EDN1	ENSPSIP00000009052	ENSPSIP00000004800	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.544
NKX2-5	EDN1	ENSPSIP00000016815	ENSPSIP00000004800	NK2 homeobox 5.	Endothelin 1.	0.526
PAX8	TG	ENSPSIP00000013570	ENSPSIP00000005299	Paired box 8.	Thyroglobulin.	0.563
TG	PAX8	ENSPSIP00000005299	ENSPSIP00000013570	Thyroglobulin.	Paired box 8.	0.563