(49 nodes) Organ growth network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMPD3	Sphingomyelin phosphodiesterase 3. (664 aa)
	BNC2	Basonuclin 2. (870 aa)
	ARX	Aristaless related homeobox. (539 aa)
	STC1	Stanniocalcin 1. (247 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	GATA6	GATA binding protein 6. (514 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	LEPR	Leptin receptor. (1150 aa)
	ANXA6	Annexin. (664 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (726 aa)
	IFT80	Intraflagellar transport 80. (778 aa)
	AR	Androgen receptor. (721 aa)
	CER1	Cerberus 1, DAN family BMP antagonist. (275 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4. (328 aa)
	HLX	H2.0 like homeobox. (354 aa)
	LOC102450523	Uncharacterized protein. (181 aa)
	FXN	Frataxin. (159 aa)
	RARB	Retinoic acid receptor beta. (448 aa)
	NPPC	Uncharacterized protein. (132 aa)
	GJE1	Gap junction protein epsilon 1. (205 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1232 aa)
	PDLIM5	PDZ and LIM domain 5. (603 aa)
	ARID2	AT-rich interaction domain 2. (1824 aa)
	K7FGP4_PELSI	TSP C-terminal domain-containing protein. (950 aa)
	TMEM38B	Transmembrane protein 38B. (279 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (584 aa)
	OSTN	Osteocrin. (134 aa)
	NKX2-5	NK2 homeobox 5. (272 aa)
	AKAP13	A-kinase anchoring protein 13. (2319 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (887 aa)
	MMP13	Matrix metallopeptidase 13. (472 aa)
	ADRA1A	Adrenoceptor alpha 1A. (467 aa)
	DIPK2A	Divergent protein kinase domain 2A. (297 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (882 aa)
	EVC	EvC ciliary complex subunit 1. (952 aa)
	SAV1	Salvador family WW domain containing protein 1. (313 aa)
	LOC102458614	Uncharacterized protein. (824 aa)
	SMAD1	Mothers against decapentaplegic homolog. (427 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (588 aa)
	IL7	Uncharacterized protein. (144 aa)
	TENM4	Teneurin transmembrane protein 4. (2608 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
	LOC102457599	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	BCL2	BCL2 apoptosis regulator. (232 aa)
	K7F553_PELSI	NR LBD domain-containing protein. (123 aa)
	RARA	Retinoic acid receptor alpha. (343 aa)
	RAG2	Recombination activating 2. (533 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSPSIP00000011283	ENSPSIP00000004470	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.679
BCL2	ESR1	ENSPSIP00000003443	ENSPSIP00000004470	BCL2 apoptosis regulator.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.518
BCL2	IL7	ENSPSIP00000003443	ENSPSIP00000004004	BCL2 apoptosis regulator.	Uncharacterized protein.	0.436
CER1	WNT2	ENSPSIP00000012861	ENSPSIP00000018663	Cerberus 1, DAN family BMP antagonist.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
CER1	WNT2B	ENSPSIP00000012861	ENSPSIP00000003858	Cerberus 1, DAN family BMP antagonist.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
ESR1	AR	ENSPSIP00000004470	ENSPSIP00000011283	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Androgen receptor.	0.679
ESR1	BCL2	ENSPSIP00000004470	ENSPSIP00000003443	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	BCL2 apoptosis regulator.	0.518
ESR1	UBE3A	ENSPSIP00000004470	ENSPSIP00000018266	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.649
FGF7	FGF8	ENSPSIP00000010002	ENSPSIP00000009052	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
FGF8	FGF7	ENSPSIP00000009052	ENSPSIP00000010002	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
GATA6	NKX2-5	ENSPSIP00000009971	ENSPSIP00000016815	GATA binding protein 6.	NK2 homeobox 5.	0.794
IL7	BCL2	ENSPSIP00000004004	ENSPSIP00000003443	Uncharacterized protein.	BCL2 apoptosis regulator.	0.436
K7F553_PELSI	RARA	ENSPSIP00000003163	ENSPSIP00000002409	NR LBD domain-containing protein.	Retinoic acid receptor alpha.	0.892
LOC102457599	SMAD1	ENSPSIP00000003778	ENSPSIP00000018548	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	Mothers against decapentaplegic homolog.	0.414
LOC102457599	TGFB2	ENSPSIP00000003778	ENSPSIP00000009346	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.986
LOC102457599	TGFBR2	ENSPSIP00000003778	ENSPSIP00000005650	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.902
NKX2-5	GATA6	ENSPSIP00000016815	ENSPSIP00000009971	NK2 homeobox 5.	GATA binding protein 6.	0.794
RARA	K7F553_PELSI	ENSPSIP00000002409	ENSPSIP00000003163	Retinoic acid receptor alpha.	NR LBD domain-containing protein.	0.892
SMAD1	LOC102457599	ENSPSIP00000018548	ENSPSIP00000003778	Mothers against decapentaplegic homolog.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.414
SMAD1	TGFBR2	ENSPSIP00000018548	ENSPSIP00000005650	Mothers against decapentaplegic homolog.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.440