STRINGSTRING
HIF1A HIF1A NDNF NDNF TSC1 TSC1 PTGS2 PTGS2 EEF2K EEF2K AK4 AK4 OPRD1 OPRD1 CPEB2 CPEB2 GATA6 GATA6 NPEPPS NPEPPS SUV39H1 SUV39H1 MYC MYC HIF1AN HIF1AN VHL VHL FNDC1 FNDC1 MTOR MTOR PDK3 PDK3 SIRT1 SIRT1 AIFM1 AIFM1 PPARD PPARD AQP5 AQP5 PINK1 PINK1 EGLN1 EGLN1 STOX1 STOX1 NDRG1 NDRG1 LOC102458614 LOC102458614 KCNK2 KCNK2 SLC9A1 SLC9A1 BCL2 BCL2 HYOU1 HYOU1 NFE2L2 NFE2L2 SIRT2 SIRT2 VEGFA VEGFA PICK1 PICK1 TBL2 TBL2 AQP1 AQP1 FABP1 FABP1 TP53 TP53 NKX3-1 NKX3-1 EGLN3 EGLN3 FAM162A FAM162A MDM4 MDM4 RBPJ RBPJ CPEB1 CPEB1 BACH1 BACH1 SUV39H2 SUV39H2 BNIP3 BNIP3 HIF3A HIF3A DDR2 DDR2 TERT TERT EPAS1 EPAS1 MGARP MGARP TIGAR TIGAR ATF4 ATF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIF1AHypoxia inducible factor 1 subunit alpha. (811 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
TSC1TSC complex subunit 1. (1168 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (658 aa)
EEF2KEukaryotic elongation factor 2 kinase. (723 aa)
AK4Adenylate kinase 4. (136 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (290 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (525 aa)
GATA6GATA binding protein 6. (514 aa)
NPEPPSAminopeptidase. (850 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (397 aa)
MYCMYC proto-oncogene, bHLH transcription factor. (324 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (296 aa)
VHLUncharacterized protein. (169 aa)
FNDC1Fibronectin type III domain containing 1. (1969 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
PDK3Protein-serine/threonine kinase. (413 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (625 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
PINK1PTEN induced kinase 1. (364 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (206 aa)
STOX1Storkhead box 1. (875 aa)
NDRG1N-myc downstream regulated 1. (402 aa)
LOC102458614Uncharacterized protein. (824 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (410 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (773 aa)
BCL2BCL2 apoptosis regulator. (232 aa)
HYOU1Uncharacterized protein. (1000 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (573 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (372 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (217 aa)
PICK1Protein interacting with PRKCA 1. (407 aa)
TBL2Transducin beta like 2. (409 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
FABP1Fatty acid binding protein 1. (128 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
NKX3-1NK3 homeobox 1. (212 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (241 aa)
FAM162AFamily with sequence similarity 162 member A. (153 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (473 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (465 aa)
CPEB1Uncharacterized protein. (335 aa)
BACH1BZIP domain-containing protein. (607 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
BNIP3BCL2 interacting protein 3. (205 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (660 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (887 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1256 aa)
EPAS1Endothelial PAS domain protein 1. (872 aa)
MGARPAIF-MLS domain-containing protein. (60 aa)
TIGARUncharacterized protein. (274 aa)
ATF4Activating transcription factor 4. (356 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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