STRINGSTRING
ATG7 ATG7 PPARGC1A PPARGC1A SFPQ SFPQ CSNK1D CSNK1D RORA RORA PPARG PPARG NONO NONO ROCK2 ROCK2 CRTC1 CRTC1 NOCT NOCT THRAP3 THRAP3 CIPC CIPC ATOH7 ATOH7 PER2 PER2 ADCY1 ADCY1 PHLPP1 PHLPP1 TIMELESS TIMELESS PPP1CC PPP1CC LOC102461184 LOC102461184 K7F6J4_PELSI K7F6J4_PELSI K7F706_PELSI K7F706_PELSI PRKAA2 PRKAA2 LOC102445801 LOC102445801 LOC102459928 LOC102459928 FBXL8 FBXL8 PSPC1 PSPC1 MAPK10 MAPK10 PER1 PER1 LOC102450917 LOC102450917 RORB RORB HDAC3 HDAC3 PIWIL2 PIWIL2 FBXL22 FBXL22 OPN5 OPN5 MTOR MTOR TARDBP TARDBP BTRC BTRC LOC102450363 LOC102450363 LOC102449437 LOC102449437 NR1D2 NR1D2 SUV39H1 SUV39H1 SIRT6 SIRT6 OPN4 OPN4 K7FPF7_PELSI K7FPF7_PELSI RORC RORC K7FQ62_PELSI K7FQ62_PELSI USP7 USP7 ARNTL2 ARNTL2 SRRD SRRD GHRL GHRL LOC102449920 LOC102449920 PPARA PPARA BHLHE40 BHLHE40 PPP1CA PPP1CA FBXW7 FBXW7 SUV39H2 SUV39H2 LOC102458141 LOC102458141 DRD4 DRD4 UBE3A UBE3A MAPK8 MAPK8 MAPK9 MAPK9 CDK1 CDK1 FBXL3 FBXL3 PPP1CB PPP1CB K7G8S3_PELSI K7G8S3_PELSI CRY1 CRY1 PRKAA1 PRKAA1 K7G473_PELSI K7G473_PELSI FBXW9 FBXW9 DDB1 DDB1 FBXL12 FBXL12 TP53 TP53 ARNTL ARNTL CRY2 CRY2 LOC102455469 LOC102455469 LOC102460658 LOC102460658 KLF10 KLF10 FBXW11 FBXW11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (661 aa)
PPARGC1APPARG coactivator 1 alpha. (795 aa)
SFPQSplicing factor proline and glutamine rich. (431 aa)
CSNK1DCasein kinase 1 delta. (426 aa)
RORARAR related orphan receptor A. (459 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (481 aa)
NONONon-POU domain containing octamer binding. (460 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
CRTC1CREB regulated transcription coactivator 1. (477 aa)
NOCTNocturnin. (495 aa)
THRAP3Thyroid hormone receptor associated protein 3. (973 aa)
CIPCUncharacterized protein. (193 aa)
ATOH7Atonal bHLH transcription factor 7. (149 aa)
PER2Period circadian regulator 2. (1328 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1090 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1170 aa)
TIMELESSTimeless circadian regulator. (863 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (349 aa)
LOC102461184Uncharacterized protein. (365 aa)
K7F6J4_PELSIUncharacterized protein. (303 aa)
K7F706_PELSIUncharacterized protein. (390 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
LOC102445801Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
LOC102459928F-box domain-containing protein. (436 aa)
FBXL8F-box domain-containing protein. (379 aa)
PSPC1Paraspeckle component 1. (525 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
PER1Period circadian regulator 1. (1017 aa)
LOC102450917Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
RORBRAR related orphan receptor B. (470 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (405 aa)
PIWIL2Uncharacterized protein; Belongs to the argonaute family. (908 aa)
FBXL22F-box and leucine rich repeat protein 22. (226 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
TARDBPTAR DNA binding protein. (414 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (594 aa)
LOC102450363G_PROTEIN_RECEP_F1_2 domain-containing protein. (546 aa)
LOC102449437FAD_binding_7 domain-containing protein. (345 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (583 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (397 aa)
SIRT6Sirtuin 6. (341 aa)
OPN4Opsin 4. (526 aa)
K7FPF7_PELSIUncharacterized protein. (54 aa)
RORCRAR related orphan receptor C. (555 aa)
K7FQ62_PELSIUncharacterized protein. (809 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1106 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (529 aa)
SRRDSRR1 domain containing. (188 aa)
GHRLGhrelin and obestatin prepropeptide. (118 aa)
LOC102449920Serine/threonine-protein phosphatase. (266 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
BHLHE40Basic helix-loop-helix family member e40. (411 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
FBXW7F-box and WD repeat domain containing 7. (610 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
LOC102458141Uncharacterized protein. (469 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (300 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (882 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
FBXL3F-box and leucine rich repeat protein 3. (433 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
K7G8S3_PELSIUncharacterized protein. (458 aa)
CRY1Cryptochrome circadian regulator 1. (568 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
K7G473_PELSIPhotolyase/cryptochrome alpha/beta domain-containing protein. (491 aa)
FBXW9F-box and WD repeat domain containing 9. (462 aa)
DDB1Damage specific DNA binding protein 1. (1124 aa)
FBXL12F-box and leucine rich repeat protein 12. (305 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like 2. (633 aa)
CRY2Cryptochrome circadian regulator 2. (521 aa)
LOC102455469G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (348 aa)
LOC102460658Photolyase/cryptochrome alpha/beta domain-containing protein. (533 aa)
KLF10Kruppel like factor 10. (482 aa)
FBXW11F-box and WD repeat domain containing 11. (615 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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