STRINGSTRING
KCNE1 KCNE1 GPER1 GPER1 AMIGO2 AMIGO2 K7F0T6_PELSI K7F0T6_PELSI PIRT PIRT ORAI1 ORAI1 APLNR APLNR ARC ARC VAMP8 VAMP8 K7GCN5_PELSI K7GCN5_PELSI CACNB4 CACNB4 DRD4 DRD4 CASK CASK NPSR1 NPSR1 WNK2 WNK2 RAMP3 RAMP3 LOC102450450 LOC102450450 PKD2 PKD2 FXYD1 FXYD1 TRH TRH K7FNV3_PELSI K7FNV3_PELSI SRI SRI PLCG1 PLCG1 SCN4B SCN4B K7FME6_PELSI K7FME6_PELSI F2RL3 F2RL3 HOMER1 HOMER1 ANO6 ANO6 ATPSCKMT ATPSCKMT COA8 COA8 TNFRSF11A TNFRSF11A ATP1B3 ATP1B3 WNK1 WNK1 GDNF GDNF ACE2 ACE2 LRRC55 LRRC55 WFS1 WFS1 R3HDM2 R3HDM2 CAV3 CAV3 PSEN1 PSEN1 EDNRA EDNRA SLC6A1 SLC6A1 LOC102443642 LOC102443642 RAB3GAP1 RAB3GAP1 PTGES PTGES LOC106731489 LOC106731489 LRRC38 LRRC38 SLC17A8 SLC17A8 RNF207 RNF207 K7FCA8_PELSI K7FCA8_PELSI PINK1 PINK1 F2 F2 NDUFA4 NDUFA4 K7FAF2_PELSI K7FAF2_PELSI LOC102458236 LOC102458236 EDN1 EDN1 WNK4 WNK4 HTT HTT NKX2-5 NKX2-5 FFAR1 FFAR1 CHP1 CHP1 PLA2G10 PLA2G10 CHP2 CHP2 BAK1 BAK1 ATP1B2 ATP1B2 K7G305_PELSI K7G305_PELSI R3HDM1 R3HDM1 K7G2Y0_PELSI K7G2Y0_PELSI LOC102461145 LOC102461145 CEBPB CEBPB AKAP6 AKAP6 SLC9A1 SLC9A1 PLA2G6 PLA2G6 K7F7G4_PELSI K7F7G4_PELSI ADCYAP1R1 ADCYAP1R1 K7F7A9_PELSI K7F7A9_PELSI RELN RELN SNX4 SNX4 CNTN1 CNTN1 PLCG2 PLCG2 ABCC8 ABCC8 TRPV2 TRPV2 P2RX1 P2RX1 CXCR3 CXCR3 STIM2 STIM2 TRPC1 TRPC1 STC1 STC1 AMIGO1 AMIGO1 SYT4 SYT4 IFNGR2 IFNGR2 G6PD G6PD PDGFB PDGFB CACNG4 CACNG4 CFTR CFTR SCN3B SCN3B AKAP7 AKAP7 K7FYF9_PELSI K7FYF9_PELSI PDZK1 PDZK1 K7FXZ1_PELSI K7FXZ1_PELSI LGALS3 LGALS3 THY1 THY1 PLA2R1 PLA2R1 ATF4 ATF4 P2RX4 P2RX4 CACNG2 CACNG2 DRD2 DRD2 STAC STAC FHL1 FHL1 P2RX7 P2RX7 TESC TESC STIM1 STIM1 VMP1 VMP1 CLTRN CLTRN KCNQ1 KCNQ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNE1Uncharacterized protein. (126 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
K7F0T6_PELSIUncharacterized protein. (375 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (132 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (185 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ARCActivity regulated cytoskeleton associated protein. (405 aa)
VAMP8Vesicle associated membrane protein 8. (103 aa)
K7GCN5_PELSIUncharacterized protein. (164 aa)
CACNB4SH3 domain-containing protein. (476 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (300 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (907 aa)
NPSR1Neuropeptide S receptor 1. (372 aa)
WNK2WNK lysine deficient protein kinase 2. (2137 aa)
RAMP3Receptor activity modifying protein 3. (203 aa)
LOC102450450Phospholipase A(2). (156 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (809 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
K7FNV3_PELSIPhosphoinositide phospholipase C. (1177 aa)
SRISorcin. (196 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1288 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (226 aa)
K7FME6_PELSIUncharacterized protein. (617 aa)
F2RL3F2R like thrombin or trypsin receptor 3. (375 aa)
HOMER1Homer scaffold protein 1. (367 aa)
ANO6Anoctamin. (908 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (267 aa)
COA8Cytochrome c oxidase assembly factor 8. (91 aa)
TNFRSF11ATNF receptor superfamily member 11a. (599 aa)
ATP1B3ATPase Na+/K+ transporting subunit beta 3. (166 aa)
WNK1WNK lysine deficient protein kinase 1. (1903 aa)
GDNFGlial cell derived neurotrophic factor. (218 aa)
ACE2Angiotensin-converting enzyme. (808 aa)
LRRC55Leucine rich repeat containing 55. (301 aa)
WFS1Wolframin ER transmembrane glycoprotein. (860 aa)
R3HDM2Uncharacterized protein. (630 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
LOC102443642C-C motif chemokine. (91 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (967 aa)
PTGESProstaglandin E synthase. (152 aa)
LOC106731489C-C motif chemokine. (91 aa)
LRRC38Leucine rich repeat containing 38. (333 aa)
SLC17A8Solute carrier family 17 member 8. (586 aa)
RNF207Ring finger protein 207. (570 aa)
K7FCA8_PELSIAKAP7_NLS domain-containing protein. (230 aa)
PINK1PTEN induced kinase 1. (364 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (611 aa)
NDUFA4NDUFA4 mitochondrial complex associated. (82 aa)
K7FAF2_PELSIANK_REP_REGION domain-containing protein. (338 aa)
LOC102458236SCY domain-containing protein. (449 aa)
EDN1Endothelin 1. (204 aa)
WNK4WNK lysine deficient protein kinase 4. (871 aa)
HTTHuntingtin. (3096 aa)
NKX2-5NK2 homeobox 5. (272 aa)
FFAR1Free fatty acid receptor 1. (257 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
PLA2G10Phospholipase A(2). (143 aa)
CHP2Calcineurin like EF-hand protein 2. (172 aa)
BAK1BCL2 antagonist/killer 1. (213 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (329 aa)
K7G305_PELSIUncharacterized protein. (430 aa)
R3HDM1R3H domain containing 1. (1092 aa)
K7G2Y0_PELSIAsp-B-Hydro_N domain-containing protein. (453 aa)
LOC102461145Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (124 aa)
CEBPBCCAAT enhancer binding protein beta. (315 aa)
AKAP6A-kinase anchoring protein 6. (2314 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (773 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
K7F7G4_PELSIReelin domain-containing protein. (177 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (473 aa)
K7F7A9_PELSIUncharacterized protein. (1108 aa)
RELNUncharacterized protein. (2100 aa)
SNX4Sorting nexin 4. (441 aa)
CNTN1Contactin 1. (1005 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ABCC8ATP binding cassette subfamily C member 8. (1538 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (733 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (374 aa)
STIM2Stromal interaction molecule 2. (654 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (783 aa)
STC1Stanniocalcin 1. (247 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (443 aa)
SYT4Synaptotagmin 4. (425 aa)
IFNGR2Interferon gamma receptor 2. (366 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (513 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (245 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (281 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1015 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
AKAP7A-kinase anchoring protein 7. (319 aa)
K7FYF9_PELSIIon_trans domain-containing protein; Belongs to the potassium channel family. (300 aa)
PDZK1PDZ domain containing 1. (518 aa)
K7FXZ1_PELSIKCNQ_channel domain-containing protein. (99 aa)
LGALS3Galectin. (290 aa)
THY1Thy-1 cell surface antigen. (182 aa)
PLA2R1Phospholipase A2 receptor 1. (1457 aa)
ATF4Activating transcription factor 4. (356 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (350 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
STACSH3 and cysteine rich domain. (405 aa)
FHL1Four and a half LIM domains 1. (297 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (566 aa)
TESCTescalcin. (214 aa)
STIM1Stromal interaction molecule 1. (683 aa)
VMP1Vacuole membrane protein 1. (406 aa)
CLTRNCollectrin domain-containing protein. (226 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (374 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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