(51 nodes) Negative regulation of ion transport network (Pelodiscus sinensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	KCNRG	Potassium channel regulator. (277 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1593 aa)
	K7GH65_PELSI	Peptidase M60 domain-containing protein. (894 aa)
	K7GH62_PELSI	Kazal-like domain-containing protein. (61 aa)
	STC1	Stanniocalcin 1. (247 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (300 aa)
	K7GCY2_PELSI	Fibronectin type-II domain-containing protein. (398 aa)
	ARL6IP5	PRA1 family protein. (188 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1303 aa)
	SLC26A5	Solute carrier family 26 member 5. (741 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (257 aa)
	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1575 aa)
	K7G3U2_PELSI	Peptidase M60 domain-containing protein. (915 aa)
	COMMD1	Copper metabolism domain containing 1. (123 aa)
	SLC43A2	Solute carrier family 43 member 2. (567 aa)
	STK39	Serine/threonine kinase 39. (430 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (440 aa)
	ATF4	Activating transcription factor 4. (356 aa)
	GOPC	PDZ domain-containing protein. (371 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (975 aa)
	SLC30A1	Solute carrier family 30 member 1. (495 aa)
	SESTD1	SEC14 and spectrin domain containing 1. (696 aa)
	FMR1	Fragile X mental retardation 1. (561 aa)
	TRH	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
	SRI	Sorcin. (196 aa)
	K7FN25_PELSI	Uncharacterized protein. (570 aa)
	PACSIN3	Protein kinase C and casein kinase substrate in neurons 3. (434 aa)
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (117 aa)
	SYT11	Synaptotagmin 11. (373 aa)
	WNK1	WNK lysine deficient protein kinase 1. (1903 aa)
	KEL	Uncharacterized protein. (703 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	REM1	RRAD and GEM like GTPase 1. (254 aa)
	OXSR1	Protein kinase domain-containing protein. (502 aa)
	ANO9	Anoctamin. (574 aa)
	SLC43A1	Solute carrier family 43 member 1. (586 aa)
	CLIC2	Chloride intracellular channel 2. (221 aa)
	PXK	PX domain containing serine/threonine kinase like. (560 aa)
	VIP	Vasoactive intestinal peptide. (203 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (396 aa)
	WNK4	WNK lysine deficient protein kinase 4. (871 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (690 aa)
	BCL2	BCL2 apoptosis regulator. (232 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2137 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	GEM	GTP binding protein overexpressed in skeletal muscle. (296 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (809 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (125 aa)
	KCNE1	Uncharacterized protein. (126 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (163 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	K7GCY2_PELSI	ENSPSIP00000003443	ENSPSIP00000018143	BCL2 apoptosis regulator.	Fibronectin type-II domain-containing protein.	0.561
BCL2	REM1	ENSPSIP00000003443	ENSPSIP00000007423	BCL2 apoptosis regulator.	RRAD and GEM like GTPase 1.	0.571
CAV3	REM1	ENSPSIP00000007448	ENSPSIP00000007423	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	RRAD and GEM like GTPase 1.	0.429
DRD3	DRD4	ENSPSIP00000002557	ENSPSIP00000018332	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	0.687
DRD4	DRD3	ENSPSIP00000018332	ENSPSIP00000002557	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family.	0.687
K7GCY2_PELSI	BCL2	ENSPSIP00000018143	ENSPSIP00000003443	Fibronectin type-II domain-containing protein.	BCL2 apoptosis regulator.	0.561
KCNE1	KCNE3	ENSPSIP00000001975	ENSPSIP00000008666	Uncharacterized protein.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.563
KCNE1	KCNE4	ENSPSIP00000001975	ENSPSIP00000000798	Uncharacterized protein.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.448
KCNE2	KCNE3	ENSPSIP00000001977	ENSPSIP00000008666	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.635
KCNE2	KCNE4	ENSPSIP00000001977	ENSPSIP00000000798	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.563
KCNE3	KCNE1	ENSPSIP00000008666	ENSPSIP00000001975	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Uncharacterized protein.	0.563
KCNE3	KCNE2	ENSPSIP00000008666	ENSPSIP00000001977	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.635
KCNE3	KCNE4	ENSPSIP00000008666	ENSPSIP00000000798	Potassium voltage-gated channel subfamily E regulatory subunit 3.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.572
KCNE4	KCNE1	ENSPSIP00000000798	ENSPSIP00000001975	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Uncharacterized protein.	0.448
KCNE4	KCNE2	ENSPSIP00000000798	ENSPSIP00000001977	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.563
KCNE4	KCNE3	ENSPSIP00000000798	ENSPSIP00000008666	Potassium voltage-gated channel subfamily E regulatory subunit 4.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.572
NEDD4	NEDD4L	ENSPSIP00000017433	ENSPSIP00000011694	NEDD4 E3 ubiquitin protein ligase.	NEDD4 like E3 ubiquitin protein ligase.	0.900
NEDD4L	NEDD4	ENSPSIP00000011694	ENSPSIP00000017433	NEDD4 like E3 ubiquitin protein ligase.	NEDD4 E3 ubiquitin protein ligase.	0.900
OXSR1	WNK1	ENSPSIP00000007253	ENSPSIP00000008180	Protein kinase domain-containing protein.	WNK lysine deficient protein kinase 1.	0.647
OXSR1	WNK4	ENSPSIP00000007253	ENSPSIP00000004720	Protein kinase domain-containing protein.	WNK lysine deficient protein kinase 4.	0.647