(14 nodes) Autophagy of nucleus network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATG2B	Autophagy related 2B. (2079 aa)
	WDR45B	WD repeat domain 45B. (335 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (414 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (555 aa)
	WIPI1	WD repeat domain, phosphoinositide interacting 1. (422 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (276 aa)
	ATG3	Autophagy-related protein 3. (289 aa)
	ATG2A	Autophagy related 2A. (2002 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1015 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (143 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1591 aa)
	LOC102450218	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (273 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1030 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (661 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG13	ENSPSIP00000019454	ENSPSIP00000007925	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.689
ATG12	ATG2A	ENSPSIP00000019454	ENSPSIP00000010531	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2A.	0.542
ATG12	ATG2B	ENSPSIP00000019454	ENSPSIP00000013916	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2B.	0.542
ATG12	ATG3	ENSPSIP00000019454	ENSPSIP00000002248	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 3.	0.999
ATG12	ATG5	ENSPSIP00000019454	ENSPSIP00000002735	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG7	ENSPSIP00000019454	ENSPSIP00000013932	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG12	LOC102450218	ENSPSIP00000019454	ENSPSIP00000016911	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.748
ATG12	RB1CC1	ENSPSIP00000019454	ENSPSIP00000016994	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	RB1 inducible coiled-coil 1.	0.737
ATG12	ULK1	ENSPSIP00000019454	ENSPSIP00000009949	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Unc-51 like autophagy activating kinase 1.	0.923
ATG12	ULK2	ENSPSIP00000019454	ENSPSIP00000017795	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Unc-51 like autophagy activating kinase 2.	0.916
ATG12	WDR45B	ENSPSIP00000019454	ENSPSIP00000013904	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain 45B.	0.647
ATG12	WIPI1	ENSPSIP00000019454	ENSPSIP00000010820	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain, phosphoinositide interacting 1.	0.903
ATG12	WIPI2	ENSPSIP00000019454	ENSPSIP00000011749	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain, phosphoinositide interacting 2.	0.925
ATG13	ATG12	ENSPSIP00000007925	ENSPSIP00000019454	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.689
ATG13	ATG2A	ENSPSIP00000007925	ENSPSIP00000010531	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy related 2A.	0.539
ATG13	ATG2B	ENSPSIP00000007925	ENSPSIP00000013916	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy related 2B.	0.517
ATG13	ATG3	ENSPSIP00000007925	ENSPSIP00000002248	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy-related protein 3.	0.668
ATG13	ATG5	ENSPSIP00000007925	ENSPSIP00000002735	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.691
ATG13	ATG7	ENSPSIP00000007925	ENSPSIP00000013932	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.669
ATG13	LOC102450218	ENSPSIP00000007925	ENSPSIP00000016911	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.969