STRINGSTRING
K7GDD4_PELSI K7GDD4_PELSI DRD4 DRD4 LOC102458141 LOC102458141 SUV39H2 SUV39H2 HLF HLF EGR1 EGR1 BHLHE41 BHLHE41 SLIT3 SLIT3 NR0B2 NR0B2 K7GGQ9_PELSI K7GGQ9_PELSI FBXW7 FBXW7 K7GHY0_PELSI K7GHY0_PELSI INHBA INHBA MC3R MC3R ATOH7 ATOH7 NRIP1 NRIP1 PER2 PER2 AANAT AANAT OGT OGT ADCY1 ADCY1 NCOR2 NCOR2 CCDC90B CCDC90B TIMELESS TIMELESS PPP1CC PPP1CC LOC102461184 LOC102461184 K7F6J4_PELSI K7F6J4_PELSI NTRK2 NTRK2 K7F706_PELSI K7F706_PELSI PRKAA2 PRKAA2 GAS2 GAS2 LOC102445801 LOC102445801 LOC102459928 LOC102459928 BTBD9 BTBD9 ESR1 ESR1 ID2 ID2 NGFR NGFR NAMPT NAMPT PTX3 PTX3 PAM PAM EP300 EP300 PTN PTN PSPC1 PSPC1 MAPK10 MAPK10 NUDT12 NUDT12 K7FE42_PELSI K7FE42_PELSI HDAC3 HDAC3 MDK MDK RAI1 RAI1 PIWIL2 PIWIL2 METTL3 METTL3 DHX9 DHX9 SIRT1 SIRT1 GPR176 GPR176 KDM5A KDM5A ZNF830 ZNF830 SP1 SP1 TOP1 TOP1 GPR157 GPR157 ENOX1 ENOX1 LOC102463063 LOC102463063 MTOR MTOR NPAS2 NPAS2 PLEKHA2 PLEKHA2 MTTP MTTP TNFRSF11A TNFRSF11A CREB1 CREB1 CYP1B1 CYP1B1 LOC102449920 LOC102449920 PPARA PPARA BHLHE40 BHLHE40 K7GJN0_PELSI K7GJN0_PELSI PPP1CA PPP1CA HOMER1 HOMER1 LOC102450363 LOC102450363 SCAPER SCAPER LOC102449437 LOC102449437 CREBBP CREBBP NR1D2 NR1D2 SUV39H1 SUV39H1 EREG EREG SIRT6 SIRT6 OPN4 OPN4 RORC RORC K7FQ62_PELSI K7FQ62_PELSI ARNTL2 ARNTL2 HNF1B HNF1B ZPBP2 ZPBP2 FBXW9 FBXW9 DRD2 DRD2 AHR AHR TRPM2 TRPM2 THRAP3 THRAP3 NOCT NOCT FSHR FSHR CRTC1 CRTC1 PER1 PER1 RORB RORB NCOR1 NCOR1 ROCK2 ROCK2 ENOX2 ENOX2 NONO NONO KDM8 KDM8 DDX5 DDX5 ATF4 ATF4 PPARG PPARG NFIL3 NFIL3 RORA RORA DTL DTL CSNK1D CSNK1D SFPQ SFPQ CLOCK CLOCK TNFAIP6 TNFAIP6 FSHB FSHB NDUFA9 NDUFA9 PPARGC1A PPARGC1A ATG7 ATG7 GPR149 GPR149 KLF10 KLF10 LOC102460658 LOC102460658 GRIN3A GRIN3A CRY2 CRY2 KDM5B KDM5B ARNTL ARNTL NFYA NFYA TP53 TP53 DDB1 DDB1 K7G473_PELSI K7G473_PELSI CIART CIART FZD4 FZD4 PRKAA1 PRKAA1 CRY1 CRY1 SGPL1 SGPL1 SLIT2 SLIT2 ATF5 ATF5 K7G8S3_PELSI K7G8S3_PELSI ID4 ID4 PPP1CB PPP1CB MYBBP1A MYBBP1A ADNP ADNP DBP DBP NAGLU NAGLU FAM155A FAM155A HTR7 HTR7 CDK1 CDK1 NTRK1 NTRK1 MAPK9 MAPK9 MYCBP2 MYCBP2 EGR3 EGR3 ENPP2 ENPP2 MAPK8 MAPK8 ID3 ID3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
K7GDD4_PELSIUncharacterized protein. (848 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (300 aa)
LOC102458141Uncharacterized protein. (469 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
HLFHLF transcription factor, PAR bZIP family member. (292 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (502 aa)
BHLHE41Basic helix-loop-helix family member e41. (455 aa)
SLIT3Slit guidance ligand 3. (1396 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (274 aa)
K7GGQ9_PELSIUncharacterized protein. (251 aa)
FBXW7F-box and WD repeat domain containing 7. (610 aa)
K7GHY0_PELSILRRNT domain-containing protein. (72 aa)
INHBAInhibin subunit beta A. (423 aa)
MC3RMelanocortin 3 receptor. (322 aa)
ATOH7Atonal bHLH transcription factor 7. (149 aa)
NRIP1Nuclear receptor interacting protein 1. (1162 aa)
PER2Period circadian regulator 2. (1328 aa)
AANATAralkylamine N-acetyltransferase. (205 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (964 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1090 aa)
NCOR2Nuclear receptor corepressor 2. (1443 aa)
CCDC90BCoiled-coil domain containing 90B. (253 aa)
TIMELESSTimeless circadian regulator. (863 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (349 aa)
LOC102461184Uncharacterized protein. (365 aa)
K7F6J4_PELSIUncharacterized protein. (303 aa)
NTRK2Tyrosine-protein kinase receptor. (814 aa)
K7F706_PELSIUncharacterized protein. (390 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
GAS2Growth arrest specific 2. (314 aa)
LOC102445801Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
LOC102459928F-box domain-containing protein. (436 aa)
BTBD9BTB domain containing 9. (631 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (588 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
NGFRNerve growth factor receptor. (309 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (492 aa)
PTX3Pentraxin 3. (430 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
EP300E1A binding protein p300. (2399 aa)
PTNPleiotrophin. (164 aa)
PSPC1Paraspeckle component 1. (525 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
NUDT12Nudix hydrolase 12. (459 aa)
K7FE42_PELSIUncharacterized protein. (581 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (405 aa)
MDKMidkine. (150 aa)
RAI1Retinoic acid induced 1. (1898 aa)
PIWIL2Uncharacterized protein; Belongs to the argonaute family. (908 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (532 aa)
DHX9DExH-box helicase 9. (1267 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
GPR176G protein-coupled receptor 176. (576 aa)
KDM5ALysine demethylase 5A. (1655 aa)
ZNF830Zinc finger protein 830. (326 aa)
SP1Sp1 transcription factor. (724 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (766 aa)
GPR157G protein-coupled receptor 157. (338 aa)
ENOX1Ecto-NOX disulfide-thiol exchanger 1. (572 aa)
LOC102463063G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (426 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
NPAS2Neuronal PAS domain protein 2. (544 aa)
PLEKHA2Pleckstrin homology domain containing A2. (385 aa)
MTTPMicrosomal triglyceride transfer protein. (893 aa)
TNFRSF11ATNF receptor superfamily member 11a. (599 aa)
CREB1cAMP responsive element binding protein 1. (327 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
LOC102449920Serine/threonine-protein phosphatase. (266 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
BHLHE40Basic helix-loop-helix family member e40. (411 aa)
K7GJN0_PELSIUncharacterized protein. (581 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
HOMER1Homer scaffold protein 1. (367 aa)
LOC102450363G_PROTEIN_RECEP_F1_2 domain-containing protein. (546 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1271 aa)
LOC102449437FAD_binding_7 domain-containing protein. (345 aa)
CREBBPCREB binding protein. (2063 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (583 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (397 aa)
EREGEpiregulin. (154 aa)
SIRT6Sirtuin 6. (341 aa)
OPN4Opsin 4. (526 aa)
RORCRAR related orphan receptor C. (555 aa)
K7FQ62_PELSIUncharacterized protein. (809 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (529 aa)
HNF1BHNF1 homeobox B. (559 aa)
ZPBP2Zona pellucida binding protein 2. (350 aa)
FBXW9F-box and WD repeat domain containing 9. (462 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
AHRUncharacterized protein. (831 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1411 aa)
THRAP3Thyroid hormone receptor associated protein 3. (973 aa)
NOCTNocturnin. (495 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
CRTC1CREB regulated transcription coactivator 1. (477 aa)
PER1Period circadian regulator 1. (1017 aa)
RORBRAR related orphan receptor B. (470 aa)
NCOR1Uncharacterized protein. (1404 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
ENOX2Ecto-NOX disulfide-thiol exchanger 2. (624 aa)
NONONon-POU domain containing octamer binding. (460 aa)
KDM8Lysine demethylase 8. (424 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (601 aa)
ATF4Activating transcription factor 4. (356 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (481 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; May act as a transcriptional regulator of a number of proteins of the circadian clock; Belongs to the bZIP family. NFIL3 subfamily. (461 aa)
RORARAR related orphan receptor A. (459 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (680 aa)
CSNK1DCasein kinase 1 delta. (426 aa)
SFPQSplicing factor proline and glutamine rich. (431 aa)
CLOCKClock circadian regulator. (850 aa)
TNFAIP6TNF alpha induced protein 6. (275 aa)
FSHBFollicle stimulating hormone subunit beta. (154 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (379 aa)
PPARGC1APPARG coactivator 1 alpha. (795 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (661 aa)
GPR149G protein-coupled receptor 149. (736 aa)
KLF10Kruppel like factor 10. (482 aa)
LOC102460658Photolyase/cryptochrome alpha/beta domain-containing protein. (533 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (952 aa)
CRY2Cryptochrome circadian regulator 2. (521 aa)
KDM5BLysine demethylase 5B. (1352 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like 2. (633 aa)
NFYANuclear transcription factor Y subunit alpha. (348 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
DDB1Damage specific DNA binding protein 1. (1124 aa)
K7G473_PELSIPhotolyase/cryptochrome alpha/beta domain-containing protein. (491 aa)
CIARTCircadian associated repressor of transcription. (411 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (395 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
CRY1Cryptochrome circadian regulator 1. (568 aa)
SGPL1Uncharacterized protein. (304 aa)
SLIT2Slit guidance ligand 2. (1381 aa)
ATF5Activating transcription factor 5. (290 aa)
K7G8S3_PELSIUncharacterized protein. (458 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (156 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
MYBBP1AMYB binding protein 1a. (967 aa)
ADNPActivity dependent neuroprotector homeobox. (1124 aa)
DBPD-box binding PAR bZIP transcription factor. (126 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (629 aa)
FAM155AFamily with sequence similarity 155 member A. (282 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (419 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
NTRK1Tyrosine-protein kinase receptor. (732 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MYCBP2MYC binding protein 2. (3494 aa)
EGR3Early growth response 3. (340 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (860 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (125 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
Server load: low (24%) [HD]