(26 nodes) Astrocyte differentiation network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EOMES	Eomesodermin. (571 aa)
	STAT3	Signal transducer and activator of transcription. (707 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (713 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (413 aa)
	GCM1	Glial cells missing transcription factor 1. (165 aa)
	PAX6	Paired box 6. (430 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1316 aa)
	ABL2	Tyrosine-protein kinase. (1103 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (895 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (726 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
	LAMB1	Laminin subunit beta 1. (1761 aa)
	C1QA	Complement C1q A chain. (219 aa)
	SOX8	SRY-box transcription factor 8. (459 aa)
	ABL1	Tyrosine-protein kinase. (1127 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (677 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	PAX4	Paired box 4. (287 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	CNTF	Ciliary neurotrophic factor. (192 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (168 aa)
	HES5	Hes family bHLH transcription factor 5. (157 aa)
	TSPAN2	Tetraspanin. (231 aa)
	PLP1	Proteolipid protein 1. (242 aa)
	PLPP3	acidPPc domain-containing protein. (312 aa)
	NF1	Neurofibromin 1. (2788 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSPSIP00000007652	ENSPSIP00000012646	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	ABL1	ENSPSIP00000012646	ENSPSIP00000007652	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
CNTF	GFAP	ENSPSIP00000005940	ENSPSIP00000015470	Ciliary neurotrophic factor.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.468
CNTF	STAT3	ENSPSIP00000005940	ENSPSIP00000018063	Ciliary neurotrophic factor.	Signal transducer and activator of transcription.	0.558
DLL1	HES5	ENSPSIP00000010919	ENSPSIP00000004302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.551
DLL1	PAX6	ENSPSIP00000010919	ENSPSIP00000014372	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Paired box 6.	0.469
EOMES	IFNG	ENSPSIP00000005762	ENSPSIP00000018881	Eomesodermin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.500
GFAP	CNTF	ENSPSIP00000015470	ENSPSIP00000005940	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Ciliary neurotrophic factor.	0.468
GFAP	PAX6	ENSPSIP00000015470	ENSPSIP00000014372	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Paired box 6.	0.641
GFAP	PLP1	ENSPSIP00000015470	ENSPSIP00000004031	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Proteolipid protein 1.	0.492
GFAP	PSEN1	ENSPSIP00000015470	ENSPSIP00000007093	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.406
GFAP	STAT3	ENSPSIP00000015470	ENSPSIP00000018063	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Signal transducer and activator of transcription.	0.404
HES5	DLL1	ENSPSIP00000004302	ENSPSIP00000010919	Hes family bHLH transcription factor 5.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.551
IFNG	EOMES	ENSPSIP00000018881	ENSPSIP00000005762	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Eomesodermin.	0.500
IFNG	STAT3	ENSPSIP00000018881	ENSPSIP00000018063	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription.	0.745
NF1	PAX4	ENSPSIP00000019599	ENSPSIP00000006762	Neurofibromin 1.	Paired box 4.	0.493
NF1	PAX6	ENSPSIP00000019599	ENSPSIP00000014372	Neurofibromin 1.	Paired box 6.	0.493
PAX4	NF1	ENSPSIP00000006762	ENSPSIP00000019599	Paired box 4.	Neurofibromin 1.	0.493
PAX6	DLL1	ENSPSIP00000014372	ENSPSIP00000010919	Paired box 6.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.469
PAX6	GFAP	ENSPSIP00000014372	ENSPSIP00000015470	Paired box 6.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.641