(55 nodes) Positive regulation of lymphocyte proliferation network (Pelodiscus sinensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (232 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (321 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	PELI1	Pellino E3 ubiquitin protein ligase 1. (447 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (172 aa)
	IL18	Interleukin 18. (200 aa)
	IL27RA	Uncharacterized protein. (465 aa)
	HHLA2	HERV-H LTR-associating 2. (352 aa)
	K7GD08_PELSI	C2H2-type domain-containing protein. (367 aa)
	LOC102448275	ZP domain-containing protein. (362 aa)
	VTCN1	IGv domain-containing protein. (151 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (284 aa)
	CD274	CD274 molecule. (294 aa)
	ATAD5	ATPase family AAA domain containing 5. (1692 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	TNFRSF13C	BaffR-Tall_bind domain-containing protein. (213 aa)
	SLC7A1	Solute carrier family 7 member 1. (628 aa)
	TIRAP	TIR domain containing adaptor protein. (232 aa)
	IGFBP2	Uncharacterized protein. (121 aa)
	CD74	CD74 molecule. (293 aa)
	NFATC2	Nuclear factor of activated T cells 2. (901 aa)
	LOC102459066	Uncharacterized protein. (196 aa)
	JAK2	Tyrosine-protein kinase. (1137 aa)
	K7G218_PELSI	TIR domain-containing protein; Belongs to the Toll-like receptor family. (1043 aa)
	IGF2	Insulin like growth factor 2. (186 aa)
	SYK	Tyrosine-protein kinase. (445 aa)
	BST1	Bone marrow stromal cell antigen 1. (318 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (547 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (273 aa)
	CD6	CD6 molecule. (608 aa)
	IL6	Interleukin 6. (211 aa)
	DHPS	Uncharacterized protein. (290 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (562 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (813 aa)
	K7FQ12_PELSI	Interleukin-1. (182 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	K7FN03_PELSI	Protein kinase domain-containing protein. (449 aa)
	CD28	CD28 molecule. (223 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (186 aa)
	ANXA1	Annexin. (342 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (736 aa)
	CARD11	Caspase recruitment domain family member 11. (1164 aa)
	JAK3	Tyrosine-protein kinase. (991 aa)
	K7FGU4_PELSI	Uncharacterized protein. (196 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (815 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (584 aa)
	ZAP70	Tyrosine-protein kinase. (614 aa)
	FADD	Fas associated via death domain. (191 aa)
	SASH3	SAM domain-containing protein. (126 aa)
	K7F8A3_PELSI	Ig-like domain-containing protein. (227 aa)
	IL7	Uncharacterized protein. (144 aa)
	BCL2	BCL2 apoptosis regulator. (232 aa)
	TNFRSF4	TNF receptor superfamily member 4. (272 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (600 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	FADD	ENSPSIP00000003443	ENSPSIP00000005216	BCL2 apoptosis regulator.	Fas associated via death domain.	0.528
BCL2	IL6	ENSPSIP00000003443	ENSPSIP00000011060	BCL2 apoptosis regulator.	Interleukin 6.	0.560
BCL2	IL7	ENSPSIP00000003443	ENSPSIP00000004004	BCL2 apoptosis regulator.	Uncharacterized protein.	0.436
BCL2	K7FQ12_PELSI	ENSPSIP00000003443	ENSPSIP00000010122	BCL2 apoptosis regulator.	Interleukin-1.	0.606
BST1	CD40LG	ENSPSIP00000013563	ENSPSIP00000011823	Bone marrow stromal cell antigen 1.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.601
CARD11	K7FN03_PELSI	ENSPSIP00000008043	ENSPSIP00000009413	Caspase recruitment domain family member 11.	Protein kinase domain-containing protein.	0.435
CARD11	RIPK2	ENSPSIP00000008043	ENSPSIP00000010794	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.435
CARD11	SYK	ENSPSIP00000008043	ENSPSIP00000013845	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.557
CARD11	TRAF6	ENSPSIP00000008043	ENSPSIP00000012215	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.807
CARD11	ZAP70	ENSPSIP00000008043	ENSPSIP00000005265	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.490
CD274	K7F8A3_PELSI	ENSPSIP00000016973	ENSPSIP00000004263	CD274 molecule.	Ig-like domain-containing protein.	0.687
CD274	PTPRC	ENSPSIP00000016973	ENSPSIP00000008230	CD274 molecule.	Protein tyrosine phosphatase receptor type C.	0.444
CD274	TNFRSF4	ENSPSIP00000016973	ENSPSIP00000002616	CD274 molecule.	TNF receptor superfamily member 4.	0.522
CD28	CD40LG	ENSPSIP00000009032	ENSPSIP00000011823	CD28 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.673
CD40LG	BST1	ENSPSIP00000011823	ENSPSIP00000013563	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Bone marrow stromal cell antigen 1.	0.601
CD40LG	CD28	ENSPSIP00000011823	ENSPSIP00000009032	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD28 molecule.	0.673
CD40LG	IL15	ENSPSIP00000011823	ENSPSIP00000019416	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin; Belongs to the IL-15/IL-21 family.	0.611
CD40LG	IL6	ENSPSIP00000011823	ENSPSIP00000011060	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin 6.	0.636
CD40LG	K7FQ12_PELSI	ENSPSIP00000011823	ENSPSIP00000010122	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-1.	0.571
CD40LG	K7G218_PELSI	ENSPSIP00000011823	ENSPSIP00000014329	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.489