(36 nodes) Negative regulation of peptidyl-tyrosine phosphorylation network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFRP2	Secreted frizzled related protein 2. (150 aa)
	LOC102445534	Uncharacterized protein. (383 aa)
	SOCS5	Suppressor of cytokine signaling 5. (535 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	K7F2U4_PELSI	PH domain-containing protein. (351 aa)
	TSG101	Tumor susceptibility 101. (385 aa)
	FAM72A	Uncharacterized protein. (149 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1830 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (394 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (760 aa)
	VPS25	Vacuolar protein sorting 25 homolog. (201 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	IBTK	Inhibitor of Bruton tyrosine kinase. (1358 aa)
	DMTN	Dematin actin binding protein. (401 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (736 aa)
	GPRC5A	G_PROTEIN_RECEP_F3_4 domain-containing protein. (358 aa)
	LOC102462376	Uncharacterized protein; Belongs to the semaphorin family. (720 aa)
	K7FT54_PELSI	SH2 domain-containing protein. (216 aa)
	FGFR1OP	FGFR1 oncogene partner. (360 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (629 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (464 aa)
	SH3BP5	SH3 domain binding protein 5. (382 aa)
	LOC102457243	FERM domain-containing protein. (644 aa)
	NF2	Neurofibromin 2. (328 aa)
	LRRK1	Leucine rich repeat kinase 1. (1796 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (857 aa)
	CBLB	Cbl proto-oncogene B. (1031 aa)
	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1. (507 aa)
	ZGPAT	Uncharacterized protein. (536 aa)
	ZFYVE28	Zinc finger FYVE-type containing 28. (897 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (1101 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	K7GH62_PELSI	Kazal-like domain-containing protein. (61 aa)
	CHMP6	Charged multivesicular body protein 6. (179 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1142 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV3	TSG101	ENSPSIP00000007448	ENSPSIP00000002704	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tumor susceptibility 101.	0.428
CBLB	K7F2U4_PELSI	ENSPSIP00000017655	ENSPSIP00000002354	Cbl proto-oncogene B.	PH domain-containing protein.	0.462
CBLB	K7FT54_PELSI	ENSPSIP00000017655	ENSPSIP00000011214	Cbl proto-oncogene B.	SH2 domain-containing protein.	0.462
CBLB	PTPN6	ENSPSIP00000017655	ENSPSIP00000013049	Cbl proto-oncogene B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.513
CHMP6	TSG101	ENSPSIP00000019832	ENSPSIP00000002704	Charged multivesicular body protein 6.	Tumor susceptibility 101.	0.914
CHMP6	VPS25	ENSPSIP00000019832	ENSPSIP00000004710	Charged multivesicular body protein 6.	Vacuolar protein sorting 25 homolog.	0.999
K7F2U4_PELSI	CBLB	ENSPSIP00000002354	ENSPSIP00000017655	PH domain-containing protein.	Cbl proto-oncogene B.	0.462
K7FT54_PELSI	CBLB	ENSPSIP00000011214	ENSPSIP00000017655	SH2 domain-containing protein.	Cbl proto-oncogene B.	0.462
LOC102457243	NF2	ENSPSIP00000015184	ENSPSIP00000015671	FERM domain-containing protein.	Neurofibromin 2.	0.901
LOC102462376	PTPRC	ENSPSIP00000009308	ENSPSIP00000008230	Uncharacterized protein; Belongs to the semaphorin family.	Protein tyrosine phosphatase receptor type C.	0.676
NF2	LOC102457243	ENSPSIP00000015671	ENSPSIP00000015184	Neurofibromin 2.	FERM domain-containing protein.	0.901
PTPN6	CBLB	ENSPSIP00000013049	ENSPSIP00000017655	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Cbl proto-oncogene B.	0.513
PTPRC	LOC102462376	ENSPSIP00000008230	ENSPSIP00000009308	Protein tyrosine phosphatase receptor type C.	Uncharacterized protein; Belongs to the semaphorin family.	0.676
PTPRC	SEMA4D	ENSPSIP00000008230	ENSPSIP00000016129	Protein tyrosine phosphatase receptor type C.	Semaphorin 4D; Belongs to the semaphorin family.	0.676
SEMA4D	PTPRC	ENSPSIP00000016129	ENSPSIP00000008230	Semaphorin 4D; Belongs to the semaphorin family.	Protein tyrosine phosphatase receptor type C.	0.676
TSG101	CAV3	ENSPSIP00000002704	ENSPSIP00000007448	Tumor susceptibility 101.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.428
TSG101	CHMP6	ENSPSIP00000002704	ENSPSIP00000019832	Tumor susceptibility 101.	Charged multivesicular body protein 6.	0.914
TSG101	VPS25	ENSPSIP00000002704	ENSPSIP00000004710	Tumor susceptibility 101.	Vacuolar protein sorting 25 homolog.	0.923
VPS25	CHMP6	ENSPSIP00000004710	ENSPSIP00000019832	Vacuolar protein sorting 25 homolog.	Charged multivesicular body protein 6.	0.999
VPS25	TSG101	ENSPSIP00000004710	ENSPSIP00000002704	Vacuolar protein sorting 25 homolog.	Tumor susceptibility 101.	0.923