STRINGSTRING
PTPN1 PTPN1 ALS2 ALS2 PTPN6 PTPN6 MAP2K5 MAP2K5 PDGFB PDGFB UVRAG UVRAG FGF2 FGF2 CCNI2 CCNI2 CCNF CCNF SYK SYK CKS2 CKS2 HIPK3 HIPK3 IGF2 IGF2 HMGCR HMGCR TPD52L1 TPD52L1 SOS1 SOS1 BMP4 BMP4 TGFA TGFA CCNH CCNH FLT1 FLT1 DAB2 DAB2 CSF1R CSF1R PKIG PKIG PARP16 PARP16 MYOCD MYOCD CCNK CCNK LOC102459066 LOC102459066 BMPR2 BMPR2 FZD4 FZD4 ADAM17 ADAM17 VEGFA VEGFA DUSP10 DUSP10 MNAT1 MNAT1 SPRY4 SPRY4 LOC102453937 LOC102453937 FGF1 FGF1 SPDYA SPDYA TRIB2 TRIB2 SASH1 SASH1 HTT HTT AKAP13 AKAP13 LYN LYN CDKN2A CDKN2A TNFAIP3 TNFAIP3 DKK1 DKK1 CAB39 CAB39 K7GCT6_PELSI K7GCT6_PELSI DIPK2A DIPK2A DRD4 DRD4 CCNE1 CCNE1 CCNA2 CCNA2 LOC102443677 LOC102443677 IFNG IFNG MAP2K7 MAP2K7 CCNG2 CCNG2 PRKAR2A PRKAR2A LATS1 LATS1 K7GG88_PELSI K7GG88_PELSI CCNI CCNI AGT AGT ERN1 ERN1 NF1 NF1 K7GH67_PELSI K7GH67_PELSI NOX4 NOX4 RASGRP1 RASGRP1 CCNY CCNY MAP3K13 MAP3K13 RPTOR RPTOR MAP3K4 MAP3K4 TRIB3 TRIB3 PIH1D1 PIH1D1 CCNB2 CCNB2 CDKN1B CDKN1B CD40LG CD40LG SESN2 SESN2 CCNB1 CCNB1 RICTOR RICTOR SPRY2 SPRY2 CCND1 CCND1 SYAP1 SYAP1 K7FT54_PELSI K7FT54_PELSI PDGFC PDGFC HEXIM1 HEXIM1 ROR2 ROR2 BLM BLM ATP2B4 ATP2B4 CCNE2 CCNE2 PRKAR1A PRKAR1A CCND3 CCND3 LRP5 LRP5 PAQR3 PAQR3 PSRC1 PSRC1 FAM20A FAM20A P2RX7 P2RX7 K7FQ52_PELSI K7FQ52_PELSI K7FQ12_PELSI K7FQ12_PELSI LRP6 LRP6 TFAP4 TFAP4 PIK3R5 PIK3R5 PSMD10 PSMD10 RPS3 RPS3 EPGN EPGN CDKN1C CDKN1C LOC102446651 LOC102446651 MLST8 MLST8 KIT KIT STRADB STRADB TRIB1 TRIB1 CCNT2 CCNT2 SLC27A1 SLC27A1 CCNJ CCNJ ADIPOQ ADIPOQ K7FLA8_PELSI K7FLA8_PELSI NHEJ1 NHEJ1 SPDYC SPDYC TNFRSF11A TNFRSF11A BMPR1A BMPR1A PTPRC PTPRC PKD1 PKD1 TELO2 TELO2 K7FI94_PELSI K7FI94_PELSI CHORDC1 CHORDC1 LATS2 LATS2 CAV3 CAV3 K7FGU4_PELSI K7FGU4_PELSI DELE1 DELE1 PSEN1 PSEN1 DBF4 DBF4 NEK10 NEK10 K7FFW8_PELSI K7FFW8_PELSI SIRT1 SIRT1 CDKN2C CDKN2C PIK3CG PIK3CG RAPGEF2 RAPGEF2 CCNG1 CCNG1 K7FER7_PELSI K7FER7_PELSI PLK1 PLK1 AIDA AIDA K7FDH8_PELSI K7FDH8_PELSI BMP2 BMP2 BMPR1B BMPR1B ENSPSIP00000005926 ENSPSIP00000005926 K7FD12_PELSI K7FD12_PELSI CCNYL1 CCNYL1 GTPBP4 GTPBP4 MTCP1 MTCP1 TNF TNF CCNL1 CCNL1 K7FA56_PELSI K7FA56_PELSI THBS1 THBS1 EDN1 EDN1 PRKAR1B PRKAR1B MACROH2A1 MACROH2A1 TMEM130 TMEM130 PKIA PKIA MEN1 MEN1 MAP3K11 MAP3K11 PDCD10 PDCD10 ARHGEF5 ARHGEF5 PTPRJ PTPRJ CCNT1 CCNT1 TSG101 TSG101 CCNA1 CCNA1 PIK3CB PIK3CB PKD2 PKD2 CDC6 CDC6 K7F2U4_PELSI K7F2U4_PELSI SORL1 SORL1 HTR2B HTR2B CAB39L CAB39L DUSP19 DUSP19 K7F1M4_PELSI K7F1M4_PELSI K7F0T6_PELSI K7F0T6_PELSI SPRY3 SPRY3 TCIM TCIM SPRY1 SPRY1 SFRP2 SFRP2 K7EW96_PELSI K7EW96_PELSI LRRK2 LRRK2 TRAF6 TRAF6 THY1 THY1 TAB1 TAB1 BCCIP BCCIP CCNJL CCNJL STRADA STRADA PRKAR2B PRKAR2B PRKAG2 PRKAG2 CCND2 CCND2 FBXO7 FBXO7 CCNO CCNO FGF18 FGF18 INPP5K INPP5K
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN1Tyrosine-protein phosphatase non-receptor type. (359 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1629 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (629 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (413 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (245 aa)
UVRAGUV radiation resistance associated. (659 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (97 aa)
CCNI2Cyclin I family member 2; Belongs to the cyclin family. (366 aa)
CCNFCyclin F; Belongs to the cyclin family. (775 aa)
SYKTyrosine-protein kinase. (445 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (64 aa)
HIPK3Homeodomain interacting protein kinase 3. (1193 aa)
IGF2Insulin like growth factor 2. (186 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (881 aa)
TPD52L1TPD52 like 1. (215 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
BMP4Bone morphogenetic protein 4. (353 aa)
TGFATransforming growth factor alpha. (162 aa)
CCNHCyclin H; Belongs to the cyclin family. (363 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
DAB2DAB adaptor protein 2. (712 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
PKIGcAMP-dependent protein kinase inhibitor gamma. (76 aa)
PARP16Poly [ADP-ribose] polymerase. (329 aa)
MYOCDPhosphatase and actin regulator. (916 aa)
CCNKCyclin K; Belongs to the cyclin family. (573 aa)
LOC102459066Uncharacterized protein. (196 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1042 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (395 aa)
ADAM17ADAM metallopeptidase domain 17. (836 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (217 aa)
DUSP10Dual specificity phosphatase 10. (480 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)
LOC102453937Uncharacterized protein. (192 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (311 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
SASH1SAM and SH3 domain containing 1. (1115 aa)
HTTHuntingtin. (3096 aa)
AKAP13A-kinase anchoring protein 13. (2319 aa)
LYNTyrosine-protein kinase. (517 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (139 aa)
TNFAIP3TNF alpha induced protein 3. (789 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (283 aa)
CAB39Calcium binding protein 39. (341 aa)
K7GCT6_PELSIINCENP_ARK-bind domain-containing protein. (850 aa)
DIPK2ADivergent protein kinase domain 2A. (297 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (300 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (404 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (362 aa)
LOC102443677Uncharacterized protein. (336 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (168 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (396 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (346 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (304 aa)
LATS1Large tumor suppressor kinase 1. (970 aa)
K7GG88_PELSIProtein kinase domain-containing protein. (580 aa)
CCNICyclin I; Belongs to the cyclin family. (390 aa)
AGTAngiotensinogen; Belongs to the serpin family. (476 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (957 aa)
NF1Neurofibromin 1. (2788 aa)
K7GH67_PELSIINCENP_N domain-containing protein. (522 aa)
NOX4NADPH oxidase 4. (459 aa)
RASGRP1RAS guanyl releasing protein 1. (720 aa)
CCNYCyclin Y; Belongs to the cyclin family. (287 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase. (873 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1245 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1555 aa)
TRIB3Uncharacterized protein. (135 aa)
PIH1D1PIH1 domain containing 1. (182 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (400 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (273 aa)
SESN2Uncharacterized protein. (443 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (410 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1715 aa)
SPRY2Sprouty RTK signaling antagonist 2. (313 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
SYAP1Synapse associated protein 1. (185 aa)
K7FT54_PELSISH2 domain-containing protein. (216 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (221 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
BLMATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (557 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1215 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (382 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (297 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1582 aa)
PAQR3Progestin and adipoQ receptor family member 3. (311 aa)
PSRC1Proline and serine rich coiled-coil 1. (253 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (412 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (566 aa)
K7FQ52_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (448 aa)
K7FQ12_PELSIInterleukin-1. (182 aa)
LRP6LDL receptor related protein 6. (1461 aa)
TFAP4Transcription factor AP-4. (299 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (190 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
EPGNEpithelial mitogen. (109 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (229 aa)
LOC102446651Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)
MLST8MTOR associated protein, LST8 homolog. (271 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (947 aa)
STRADBSTE20 related adaptor beta. (416 aa)
TRIB1Tribbles pseudokinase 1. (257 aa)
CCNT2Cyclin T2. (319 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
CCNJCyclin J; Belongs to the cyclin family. (383 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (243 aa)
K7FLA8_PELSIUncharacterized protein. (2557 aa)
NHEJ1Non-homologous end joining factor 1. (206 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (301 aa)
TNFRSF11ATNF receptor superfamily member 11a. (599 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (736 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4156 aa)
TELO2Telomere maintenance 2. (820 aa)
K7FI94_PELSIANK_REP_REGION domain-containing protein. (145 aa)
CHORDC1Cysteine and histidine rich domain containing 1. (355 aa)
LATS2Non-specific serine/threonine protein kinase. (1125 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
K7FGU4_PELSIUncharacterized protein. (196 aa)
DELE1Uncharacterized protein. (525 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
DBF4DBF4 zinc finger. (675 aa)
NEK10NIMA related kinase 10. (1011 aa)
K7FFW8_PELSIDH domain-containing protein. (347 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (607 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (169 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1644 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
K7FER7_PELSIKEN domain-containing protein. (85 aa)
PLK1Polo like kinase 1. (418 aa)
AIDAAxin interactor, dorsalization associated. (279 aa)
K7FDH8_PELSIUncharacterized protein. (118 aa)
BMP2Bone morphogenetic protein 2. (389 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (534 aa)
ENSPSIP00000005926annotation not available (72 aa)
K7FD12_PELSIUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (546 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (350 aa)
GTPBP4GTP binding protein 4. (383 aa)
MTCP1Uncharacterized protein. (72 aa)
TNFTumor necrosis factor. (229 aa)
CCNL1Cyclin L1; Belongs to the cyclin family. (443 aa)
K7FA56_PELSIUncharacterized protein. (4129 aa)
THBS1Thrombospondin 1. (1176 aa)
EDN1Endothelin 1. (204 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
TMEM130Transmembrane protein 130. (437 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
MEN1Menin 1. (605 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (862 aa)
PDCD10Programmed cell death 10. (212 aa)
ARHGEF5Uncharacterized protein. (520 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1341 aa)
CCNT1Cyclin T1. (657 aa)
TSG101Tumor susceptibility 101. (385 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (416 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (809 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (548 aa)
K7F2U4_PELSIPH domain-containing protein. (351 aa)
SORL1Sortilin related receptor 1. (2124 aa)
HTR2B5-hydroxytryptamine receptor 2B. (433 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (215 aa)
K7F1M4_PELSIUncharacterized protein. (56 aa)
K7F0T6_PELSIUncharacterized protein. (375 aa)
SPRY3Sprouty RTK signaling antagonist 3. (290 aa)
TCIMTranscriptional and immune response regulator. (105 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
SFRP2Secreted frizzled related protein 2. (150 aa)
K7EW96_PELSIUncharacterized protein. (63 aa)
LRRK2Leucine rich repeat kinase 2. (2537 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (547 aa)
THY1Thy-1 cell surface antigen. (182 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (563 aa)
BCCIPProtein BCCIP homolog; Belongs to the BCP1 family. (262 aa)
CCNJLCyclin J like; Belongs to the cyclin family. (473 aa)
STRADASTE20 related adaptor alpha. (430 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (309 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
FBXO7F-box protein 7. (459 aa)
CCNOCyclin O; Belongs to the cyclin family. (258 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (204 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (440 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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