STRINGSTRING
PSMD12 PSMD12 USP30 USP30 UBFD1 UBFD1 SMAD2 SMAD2 SNX3 SNX3 PSMD13 PSMD13 NPEPL1 NPEPL1 SNX12 SNX12 PSMA4 PSMA4 USP25 USP25 IFIH1 IFIH1 USP9X USP9X CDC20 CDC20 USP14 USP14 OTUB1 OTUB1 MYC MYC SKP2 SKP2 TAF10 TAF10 CLSPN CLSPN RCE1 RCE1 CYLD CYLD USP49 USP49 PTRH2 PTRH2 PSMD10 PSMD10 PSMA6 PSMA6 USP28 USP28 USP37 USP37 DDB2 DDB2 K7FQ52_PELSI K7FQ52_PELSI LOC102458553 LOC102458553 CDC20B CDC20B USP7 USP7 NFKBIA NFKBIA PSMD7 PSMD7 LOC102458989 LOC102458989 PSMB3 PSMB3 WDR76 WDR76 NRDC NRDC USP13 USP13 AR AR SMURF2 SMURF2 ARR3 ARR3 K7FU29_PELSI K7FU29_PELSI K7FUJ5_PELSI K7FUJ5_PELSI LOC102448753 LOC102448753 SMAD3 SMAD3 AXIN1 AXIN1 RIPK1 RIPK1 RNF128 RNF128 TADA2B TADA2B PSMD3 PSMD3 USP32 USP32 USP12 USP12 TRAF6 TRAF6 TOMM20 TOMM20 RNF146 RNF146 PSMB2 PSMB2 K7FWC4_PELSI K7FWC4_PELSI UBA52 UBA52 KXD1 KXD1 PSMC1 PSMC1 IDE IDE PSMA1 PSMA1 LOC102448690 LOC102448690 DDX58 DDX58 PSME4 PSME4 USP5 USP5 USP47 USP47 GATA3 GATA3 PSMC2 PSMC2 ZFYVE19 ZFYVE19 USP42 USP42 TP53 TP53 PSMC6 PSMC6 LOC102462537 LOC102462537 K7G381_PELSI K7G381_PELSI KLHL17 KLHL17 RPS27A RPS27A ATXN7L2 ATXN7L2 IKBKG IKBKG PSMA5 PSMA5 FKBP8 FKBP8 USP2 USP2 USP33 USP33 TAB1 TAB1 BIRC7 BIRC7 ARRB2 ARRB2 TGFBR1 TGFBR1 K7GJB6_PELSI K7GJB6_PELSI USP8 USP8 USP50 USP50 PSMD4 PSMD4 PSMA2 PSMA2 WDR20 WDR20 KLHL18 KLHL18 STAM2 STAM2 USP16 USP16 USP46 USP46 MDM4 MDM4 CFTR CFTR TNKS2 TNKS2 VDAC2 VDAC2 DHX58 DHX58 CCNA2 CCNA2 USP44 USP44 LAP3 LAP3 PSMF1 PSMF1 SMAD1 SMAD1 MDM2 MDM2 USP10 USP10 PSMA7 PSMA7 PSMC4 PSMC4 PSMD9 PSMD9 USP22 USP22 RNF123 RNF123 MAP3K20 MAP3K20 MTFP1 MTFP1 AXIN2 AXIN2 USP18 USP18 LOC102455075 LOC102455075 RUVBL1 RUVBL1 DMWD DMWD SMAD4 SMAD4 USP34 USP34 PSMA3 PSMA3 USP4 USP4 LOC102452578 LOC102452578 LOC102453087 LOC102453087 K7EXK2_PELSI K7EXK2_PELSI LOC102454821 LOC102454821 LOC102455573 LOC102455573 LOC102444105 LOC102444105 LOC102446769 LOC102446769 K7F0N6_PELSI K7F0N6_PELSI LOC102451747 LOC102451747 LOC102451988 LOC102451988 FOXO4 FOXO4 PSMD1 PSMD1 K7F3C8_PELSI K7F3C8_PELSI CCNA1 CCNA1 PSMA8 PSMA8 TADA3 TADA3 PSMD6 PSMD6 ATXN7 ATXN7 UFD1 UFD1 UBC UBC PSMD11 PSMD11 TNKS TNKS PSMB6 PSMB6 USP24 USP24 ADRM1 ADRM1 K7F7E8_PELSI K7F7E8_PELSI LOC102449128 LOC102449128 TOMM70 TOMM70 CCP110 CCP110 TRRAP TRRAP SUDS3 SUDS3 RNF167 RNF167 PSMC3 PSMC3 WDR48 WDR48 PSMD14 PSMD14 ATXN7L1 ATXN7L1 USP48 USP48 POLB POLB BECN1 BECN1 PSMC5 PSMC5 VDAC3 VDAC3 USP21 USP21 VDAC1 VDAC1 USP15 USP15 PSMD8 PSMD8 RNF13 RNF13 MUL1 MUL1 PSMB7 PSMB7 PSMB4 PSMB4 MAT2B MAT2B ZFYVE1 ZFYVE1 USP20 USP20 PSMD5 PSMD5 UBLCP1 UBLCP1 USP3 USP3 SMAD7 SMAD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD12Proteasome 26S subunit, non-ATPase 12. (420 aa)
USP30Ubiquitin carboxyl-terminal hydrolase. (489 aa)
UBFD1Ubiquitin family domain containing 1. (194 aa)
SMAD2Mothers against decapentaplegic homolog. (496 aa)
SNX3Sorting nexin 3. (162 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (365 aa)
NPEPL1Aminopeptidase like 1. (480 aa)
SNX12Sorting nexin 12. (129 aa)
PSMA4Proteasome subunit alpha type. (262 aa)
USP25Ubiquitin carboxyl-terminal hydrolase. (663 aa)
IFIH1Interferon induced with helicase C domain 1. (1018 aa)
USP9XUSP domain-containing protein; Belongs to the peptidase C19 family. (2555 aa)
CDC20Cell division cycle 20. (511 aa)
USP14Ubiquitin carboxyl-terminal hydrolase. (480 aa)
OTUB1OTU deubiquitinase, ubiquitin aldehyde binding 1. (264 aa)
MYCMYC proto-oncogene, bHLH transcription factor. (324 aa)
SKP2S-phase kinase associated protein 2. (419 aa)
TAF10TATA-box binding protein associated factor 10. (124 aa)
CLSPNClaspin. (1345 aa)
RCE1Ras converting CAAX endopeptidase 1. (259 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (886 aa)
USP49Ubiquitin carboxyl-terminal hydrolase. (698 aa)
PTRH2Peptidyl-tRNA hydrolase 2. (180 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (190 aa)
PSMA6Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1126 aa)
USP37Ubiquitin carboxyl-terminal hydrolase. (989 aa)
DDB2Damage specific DNA binding protein 2. (508 aa)
K7FQ52_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (448 aa)
LOC102458553Uncharacterized protein; Belongs to the peptidase C19 family. (788 aa)
CDC20BCell division cycle 20B. (535 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1106 aa)
NFKBIAANK_REP_REGION domain-containing protein. (238 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (323 aa)
LOC102458989Uncharacterized protein. (777 aa)
PSMB3Proteasome subunit beta. (204 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (598 aa)
NRDCUncharacterized protein; Belongs to the peptidase M16 family. (1149 aa)
USP13Ubiquitin carboxyl-terminal hydrolase. (862 aa)
ARAndrogen receptor. (721 aa)
SMURF2E3 ubiquitin-protein ligase. (734 aa)
ARR3Arrestin 3. (407 aa)
K7FU29_PELSIUncharacterized protein. (813 aa)
K7FUJ5_PELSIHECT domain-containing protein. (261 aa)
LOC102448753Uncharacterized protein. (611 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
AXIN1Axin 1. (857 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (716 aa)
RNF128Ring finger protein 128. (269 aa)
TADA2BTranscriptional adapter. (420 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (461 aa)
USP32Uncharacterized protein; Belongs to the peptidase C19 family. (1566 aa)
USP12Ubiquitin specific peptidase 12; Belongs to the peptidase C19 family. (364 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (547 aa)
TOMM20Translocase of outer mitochondrial membrane 20. (146 aa)
RNF146Ring finger protein 146. (353 aa)
PSMB2Proteasome subunit beta. (171 aa)
K7FWC4_PELSIUncharacterized protein. (455 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1KxDL motif containing 1. (176 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (439 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1008 aa)
PSMA1Proteasome endopeptidase complex. (236 aa)
LOC102448690USP domain-containing protein; Belongs to the peptidase C19 family. (369 aa)
DDX58DExD/H-box helicase 58. (928 aa)
PSME4Proteasome activator subunit 4. (1837 aa)
USP5Ubiquitin carboxyl-terminal hydrolase. (857 aa)
USP47Uncharacterized protein. (816 aa)
GATA3GATA binding protein 3. (425 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (437 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (429 aa)
USP42Ubiquitin specific peptidase 42; Belongs to the peptidase C19 family. (1309 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (288 aa)
LOC102462537RING-type domain-containing protein. (288 aa)
K7G381_PELSIRING-type domain-containing protein. (351 aa)
KLHL17Kelch like family member 17. (601 aa)
RPS27AUbiquitin-like domain-containing protein. (140 aa)
ATXN7L2Ataxin 7 like 2. (514 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (585 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (237 aa)
FKBP8Peptidylprolyl isomerase. (419 aa)
USP2USP domain-containing protein; Belongs to the peptidase C19 family. (311 aa)
USP33Ubiquitin carboxyl-terminal hydrolase. (913 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (563 aa)
BIRC7Baculoviral IAP repeat containing 7. (352 aa)
ARRB2Arrestin beta 2. (411 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
K7GJB6_PELSIUncharacterized protein. (301 aa)
USP8Uncharacterized protein; Belongs to the peptidase C19 family. (861 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (318 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
PSMA2Proteasome endopeptidase complex. (156 aa)
WDR20WD repeat domain 20. (594 aa)
KLHL18Kelch like family member 18. (552 aa)
STAM2Signal transducing adaptor molecule 2. (473 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (828 aa)
USP46Ubiquitin specific peptidase 46; Belongs to the peptidase C19 family. (367 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (473 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1015 aa)
TNKS2Poly [ADP-ribose] polymerase. (1101 aa)
VDAC2Voltage dependent anion channel 2. (322 aa)
DHX58DExH-box helicase 58. (670 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (362 aa)
USP44Ubiquitinyl hydrolase 1. (578 aa)
LAP3Leucine aminopeptidase 3. (491 aa)
PSMF1PI31_Prot_C domain-containing protein. (174 aa)
SMAD1Mothers against decapentaplegic homolog. (427 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (465 aa)
USP10Ubiquitin specific peptidase 10; Belongs to the peptidase C19 family. (531 aa)
PSMA7Proteasome endopeptidase complex. (220 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (406 aa)
PSMD9PDZ domain-containing protein. (166 aa)
USP22Ubiquitin carboxyl-terminal hydrolase. (494 aa)
RNF123B30.2/SPRY domain-containing protein. (281 aa)
MAP3K20Uncharacterized protein. (796 aa)
MTFP1Mitochondrial fission process 1. (180 aa)
AXIN2Axin 2. (836 aa)
USP18USP domain-containing protein; Belongs to the peptidase C19 family. (364 aa)
LOC102455075Arrestin_C domain-containing protein. (432 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (396 aa)
DMWDDM1 locus, WD repeat containing. (588 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3551 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
USP4Ubiquitin carboxyl-terminal hydrolase. (971 aa)
LOC102452578Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102453087Histone H2B 8. (126 aa)
K7EXK2_PELSIUbiquitin-like domain-containing protein. (32 aa)
LOC102454821Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102455573Histone H2B 8. (126 aa)
LOC102444105Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102446769Histone H2B 8. (126 aa)
K7F0N6_PELSISWIB domain-containing protein. (130 aa)
LOC102451747Histone H2B 1/2/3/4/6. (126 aa)
LOC102451988Histone H2B; Belongs to the histone H2B family. (126 aa)
FOXO4Forkhead box O4. (379 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (809 aa)
K7F3C8_PELSIProteasome subunit alpha type. (245 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (416 aa)
PSMA8Proteasome endopeptidase complex. (194 aa)
TADA3Transcriptional adaptor 3. (349 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (371 aa)
ATXN7SCA7 domain-containing protein. (724 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
UBCUncharacterized protein. (355 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (393 aa)
TNKSPoly [ADP-ribose] polymerase. (1133 aa)
PSMB6Proteasome subunit beta 6. (228 aa)
USP24Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. (2515 aa)
ADRM1Adhesion regulating molecule 1. (456 aa)
K7F7E8_PELSIHistone H2B; Belongs to the histone H2B family. (134 aa)
LOC102449128Histone H2B; Belongs to the histone H2B family. (134 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (501 aa)
CCP110Centriolar coiled-coil protein 110. (956 aa)
TRRAPTransformation/transcription domain associated protein. (2458 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (268 aa)
RNF167Ring finger protein 167. (346 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (426 aa)
WDR48WD repeat domain 48. (682 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
ATXN7L1Ataxin 7 like 1. (884 aa)
USP48Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (924 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (319 aa)
BECN1Uncharacterized protein. (407 aa)
PSMC5Proteasome 26S subunit, ATPase 5. (228 aa)
VDAC3Voltage dependent anion channel 3. (296 aa)
USP21Ubiquitin carboxyl-terminal hydrolase. (672 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
USP15Ubiquitin carboxyl-terminal hydrolase. (984 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (244 aa)
RNF13Ring finger protein 13. (381 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (230 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (322 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (781 aa)
USP20Ubiquitin carboxyl-terminal hydrolase. (909 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (453 aa)
UBLCP1Ubiquitin like domain containing CTD phosphatase 1. (318 aa)
USP3Ubiquitin carboxyl-terminal hydrolase. (435 aa)
SMAD7Mothers against decapentaplegic homolog. (387 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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