STRINGSTRING
PSMB3 PSMB3 POLA1 POLA1 CCNE2 CCNE2 MCM7 MCM7 MCM6 MCM6 CDK7 CDK7 LOC102461321 LOC102461321 CCND1 CCND1 K7FU29_PELSI K7FU29_PELSI LOC102463705 LOC102463705 K7FUU4_PELSI K7FUU4_PELSI CDKN1B CDKN1B PSMD3 PSMD3 PSMB2 PSMB2 K7FWC4_PELSI K7FWC4_PELSI MCM2 MCM2 UBA52 UBA52 KXD1 KXD1 PSMB1 PSMB1 ORC3 ORC3 PSMA5 PSMA5 MCM9 MCM9 CKS2 CKS2 RPS27A RPS27A MEIOB MEIOB CDK3 CDK3 CCNH CCNH PPP2CB PPP2CB PSMC6 PSMC6 FNBP4 FNBP4 PPP2R3B PPP2R3B PSMC2 PSMC2 LOC102462305 LOC102462305 PSMA1 PSMA1 K7G5T8_PELSI K7G5T8_PELSI ORC6 ORC6 PPP2R3A PPP2R3A PSMC1 PSMC1 MNAT1 MNAT1 PSMA3 PSMA3 POLE3 POLE3 PRIM2 PRIM2 CUL1 CUL1 RPA1 RPA1 PSMD9 PSMD9 MCM10 MCM10 POLE POLE PSMC4 PSMC4 PSMD2 PSMD2 CCNE1 CCNE1 PSMF1 PSMF1 CCNA2 CCNA2 PSMA2 PSMA2 PSMD4 PSMD4 MCM8 MCM8 K7EXK2_PELSI K7EXK2_PELSI K7F1M4_PELSI K7F1M4_PELSI PSMD1 PSMD1 CDC6 CDC6 K7F3C8_PELSI K7F3C8_PELSI CDC7 CDC7 CCNA1 CCNA1 PSMD6 PSMD6 CDC45 CDC45 CDK2 CDK2 CDT1 CDT1 UBC UBC PSMD11 PSMD11 K7F650_PELSI K7F650_PELSI PSMB6 PSMB6 PPP2R1A PPP2R1A K7F6A0_PELSI K7F6A0_PELSI ORC5 ORC5 PSMC3 PSMC3 ORC2 ORC2 PSMD14 PSMD14 CABLES2 CABLES2 RBBP8NL RBBP8NL RPA3 RPA3 PSMC5 PSMC5 PPP2CA PPP2CA SKP1 SKP1 GMNN GMNN AKT3 AKT3 PSMD8 PSMD8 PSMB7 PSMB7 PSMB4 PSMB4 PSMD5 PSMD5 CABLES1 CABLES1 PSMD12 PSMD12 DBF4 DBF4 MCM3 MCM3 ORC4 ORC4 PSMD13 PSMD13 PSMA4 PSMA4 POLE2 POLE2 RELCH RELCH AKT1 AKT1 PPP2R3C PPP2R3C PPP4R1 PPP4R1 SKP2 SKP2 CDKN1C CDKN1C MCM5 MCM5 PSMD10 PSMD10 PSMA6 PSMA6 RB1 RB1 PPP4R4 PPP4R4 WEE1 WEE1 PSMD7 PSMD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB3Proteasome subunit beta. (204 aa)
POLA1DNA polymerase. (1351 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (615 aa)
MCM6DNA helicase; Belongs to the MCM family. (811 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
LOC102461321WRNPLPNID domain-containing protein. (929 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
K7FU29_PELSIUncharacterized protein. (813 aa)
LOC102463705Uncharacterized protein. (526 aa)
K7FUU4_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (191 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (461 aa)
PSMB2Proteasome subunit beta. (171 aa)
K7FWC4_PELSIUncharacterized protein. (455 aa)
MCM2DNA helicase; Belongs to the MCM family. (826 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1KxDL motif containing 1. (176 aa)
PSMB1Proteasome subunit beta. (240 aa)
ORC3Origin recognition complex subunit 3. (724 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (237 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1183 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (64 aa)
RPS27AUbiquitin-like domain-containing protein. (140 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
CCNHCyclin H; Belongs to the cyclin family. (363 aa)
PPP2CBSerine/threonine-protein phosphatase. (307 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (288 aa)
FNBP4Formin binding protein 4. (894 aa)
PPP2R3BUncharacterized protein. (584 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (437 aa)
LOC102462305DNA helicase; Belongs to the MCM family. (812 aa)
PSMA1Proteasome endopeptidase complex. (236 aa)
K7G5T8_PELSIDNA helicase; Belongs to the MCM family. (840 aa)
ORC6Origin recognition complex subunit 6. (272 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1117 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (439 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (141 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (545 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
PSMD9PDZ domain-containing protein. (166 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (865 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2166 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (406 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (911 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (404 aa)
PSMF1PI31_Prot_C domain-containing protein. (174 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (362 aa)
PSMA2Proteasome endopeptidase complex. (156 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (825 aa)
K7EXK2_PELSIUbiquitin-like domain-containing protein. (32 aa)
K7F1M4_PELSIUncharacterized protein. (56 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (809 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (548 aa)
K7F3C8_PELSIProteasome subunit alpha type. (245 aa)
CDC7Cell division cycle 7. (569 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (416 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (371 aa)
CDC45Cell division cycle 45. (596 aa)
CDK2Cyclin dependent kinase 2. (259 aa)
CDT1Chromatin licensing and DNA replication factor 1. (689 aa)
UBCUncharacterized protein. (355 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (393 aa)
K7F650_PELSIDNA primase; Belongs to the eukaryotic-type primase small subunit family. (382 aa)
PSMB6Proteasome subunit beta 6. (228 aa)
PPP2R1AUncharacterized protein. (175 aa)
K7F6A0_PELSIUncharacterized protein. (163 aa)
ORC5Origin recognition complex subunit 5. (447 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (426 aa)
ORC2Origin recognition complex subunit 2. (585 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
CABLES2Cdk5 and Abl enzyme substrate 2. (318 aa)
RBBP8NLRBBP8 N-terminal like. (618 aa)
RPA3Replication protein A3. (119 aa)
PSMC5Proteasome 26S subunit, ATPase 5. (228 aa)
PPP2CASerine/threonine-protein phosphatase. (244 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
GMNNGeminin DNA replication inhibitor. (223 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (244 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (230 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (453 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (353 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (420 aa)
DBF4DBF4 zinc finger. (675 aa)
MCM3DNA helicase; Belongs to the MCM family. (788 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (365 aa)
PSMA4Proteasome subunit alpha type. (262 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (503 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (945 aa)
SKP2S-phase kinase associated protein 2. (419 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (229 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (190 aa)
PSMA6Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa)
RB1RB transcriptional corepressor 1. (917 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (864 aa)
WEE1Wee1-like protein kinase. (510 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (323 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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