STRINGSTRING
PSMC6 PSMC6 LOC102454764 LOC102454764 GINS2 GINS2 RFC2 RFC2 CCNH CCNH CDK3 CDK3 PSMC4 PSMC4 POLE POLE ANAPC4 ANAPC4 PSMD9 PSMD9 RPA1 RPA1 CUL1 CUL1 PRIM2 PRIM2 MEIOB MEIOB RPS27A RPS27A RAD21 RAD21 CKS2 CKS2 LIG1 LIG1 MCM9 MCM9 ANAPC7 ANAPC7 FZR1 FZR1 PSMA5 PSMA5 ORC3 ORC3 PSMB1 PSMB1 RCBTB2 RCBTB2 ANAPC2 ANAPC2 STAG1 STAG1 KXD1 KXD1 UBA52 UBA52 K7FWJ1_PELSI K7FWJ1_PELSI MCM2 MCM2 K7FWC4_PELSI K7FWC4_PELSI PSMB2 PSMB2 SMC3 SMC3 K7GAN8_PELSI K7GAN8_PELSI PSMD3 PSMD3 CDKN1B CDKN1B K7FUU4_PELSI K7FUU4_PELSI LOC102463705 LOC102463705 K7FU29_PELSI K7FU29_PELSI CCND1 CCND1 CDK7 CDK7 MCM6 MCM6 MCM7 MCM7 CCNE2 CCNE2 POLA1 POLA1 PSMB3 PSMB3 PSMD7 PSMD7 WAPL WAPL WEE1 WEE1 CDC27 CDC27 RB1 RB1 ANAPC5 ANAPC5 PSMA6 PSMA6 PSMD10 PSMD10 MCM5 MCM5 ESCO1 ESCO1 CDKN1C CDKN1C RFC1 RFC1 DNA2 DNA2 POLE2 POLE2 PSMA4 PSMA4 TM7SF3 TM7SF3 CDC16 CDC16 PSMD13 PSMD13 ORC4 ORC4 POLD2 POLD2 MCM3 MCM3 PDS5B PDS5B PSMD12 PSMD12 CABLES1 CABLES1 PSMD5 PSMD5 PSMB4 PSMB4 CDCA5 CDCA5 PSMB7 PSMB7 PSMD8 PSMD8 AKT3 AKT3 GMNN GMNN SKP1 SKP1 RFC5 RFC5 GINS3 GINS3 ANAPC10 ANAPC10 RBX1 RBX1 GINS4 GINS4 PSMC5 PSMC5 RPA3 RPA3 RBBP8NL RBBP8NL CABLES2 CABLES2 PSMD14 PSMD14 K7F905_PELSI K7F905_PELSI ORC2 ORC2 SKP2 SKP2 RFC3 RFC3 CDC23 CDC23 AKT1 AKT1 POLD3 POLD3 STAG3 STAG3 PSME4 PSME4 MCM8 MCM8 PSMD4 PSMD4 PDS5A PDS5A PSMA2 PSMA2 SMC1B SMC1B K7GID7_PELSI K7GID7_PELSI ANAPC16 ANAPC16 ESCO2 ESCO2 ANAPC11 ANAPC11 RFC4 RFC4 TCERG1L TCERG1L CCNA2 CCNA2 CCNE1 CCNE1 PSMF1 PSMF1 RAD21L1 RAD21L1 PSMD2 PSMD2 PSMA7 PSMA7 FEN1 FEN1 K7EXK2_PELSI K7EXK2_PELSI K7F1M4_PELSI K7F1M4_PELSI PCNA PCNA RCBTB1 RCBTB1 PSMD1 PSMD1 CDC6 CDC6 K7F3C8_PELSI K7F3C8_PELSI CCNA1 CCNA1 PSMA8 PSMA8 PSMD6 PSMD6 CDK2 CDK2 CDT1 CDT1 UBC UBC PSMD11 PSMD11 K7F650_PELSI K7F650_PELSI PSMB6 PSMB6 FAM89B FAM89B GINS1 GINS1 ORC5 ORC5 PSMC3 PSMC3 POLE3 POLE3 UBE2S UBE2S ATAD5 ATAD5 ANAPC1 ANAPC1 STAG2 STAG2 PSMA3 PSMA3 MNAT1 MNAT1 PSMC1 PSMC1 ORC6 ORC6 K7G5T8_PELSI K7G5T8_PELSI PSMA1 PSMA1 LOC102462305 LOC102462305 PSMC2 PSMC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (288 aa)
LOC102454764SCD domain-containing protein. (1260 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (191 aa)
RFC2Replication factor C subunit 2. (374 aa)
CCNHCyclin H; Belongs to the cyclin family. (363 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (406 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2166 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (800 aa)
PSMD9PDZ domain-containing protein. (166 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (545 aa)
MEIOBMeiosis specific with OB-fold. (467 aa)
RPS27AUbiquitin-like domain-containing protein. (140 aa)
RAD21RAD21 cohesin complex component. (631 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (64 aa)
LIG1DNA ligase. (954 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1183 aa)
ANAPC7Anaphase promoting complex subunit 7. (498 aa)
FZR1Fizzy and cell division cycle 20 related 1. (495 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (237 aa)
ORC3Origin recognition complex subunit 3. (724 aa)
PSMB1Proteasome subunit beta. (240 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (552 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (771 aa)
STAG1Stromal antigen 1. (1271 aa)
KXD1KxDL motif containing 1. (176 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
K7FWJ1_PELSIUBIQUITIN_CONJUGAT_2 domain-containing protein. (164 aa)
MCM2DNA helicase; Belongs to the MCM family. (826 aa)
K7FWC4_PELSIUncharacterized protein. (455 aa)
PSMB2Proteasome subunit beta. (171 aa)
SMC3Structural maintenance of chromosomes protein. (1223 aa)
K7GAN8_PELSIUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (107 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (461 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
K7FUU4_PELSIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (191 aa)
LOC102463705Uncharacterized protein. (526 aa)
K7FU29_PELSIUncharacterized protein. (813 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
MCM6DNA helicase; Belongs to the MCM family. (811 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (615 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
POLA1DNA polymerase. (1351 aa)
PSMB3Proteasome subunit beta. (204 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (323 aa)
WAPLWAPL cohesin release factor. (1199 aa)
WEE1Wee1-like protein kinase. (510 aa)
CDC27Cell division cycle 27. (834 aa)
RB1RB transcriptional corepressor 1. (917 aa)
ANAPC5Anaphase promoting complex subunit 5. (703 aa)
PSMA6Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (190 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ESCO1Establishment of sister chromatid cohesion N-acetyltransferase 1. (1018 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (229 aa)
RFC1Replication factor C subunit 1. (1146 aa)
DNA2DNA replication helicase/nuclease 2. (714 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
PSMA4Proteasome subunit alpha type. (262 aa)
TM7SF3Transmembrane 7 superfamily member 3. (568 aa)
CDC16Cell division cycle 16. (623 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (365 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
POLD2DNA polymerase delta 2, accessory subunit. (470 aa)
MCM3DNA helicase; Belongs to the MCM family. (788 aa)
PDS5BPDS5 cohesin associated factor B. (1413 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (420 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (353 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (453 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (230 aa)
CDCA5Cell division cycle associated 5. (223 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (244 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GMNNGeminin DNA replication inhibitor. (223 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
RFC5Replication factor C subunit 5. (319 aa)
GINS3GINS complex subunit 3. (156 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
RBX1Ring-box 1. (120 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (169 aa)
PSMC5Proteasome 26S subunit, ATPase 5. (228 aa)
RPA3Replication protein A3. (119 aa)
RBBP8NLRBBP8 N-terminal like. (618 aa)
CABLES2Cdk5 and Abl enzyme substrate 2. (318 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
K7F905_PELSIUncharacterized protein. (228 aa)
ORC2Origin recognition complex subunit 2. (585 aa)
SKP2S-phase kinase associated protein 2. (419 aa)
RFC3Replication factor C subunit 3. (304 aa)
CDC23Cell division cycle 23. (738 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
POLD3Uncharacterized protein. (420 aa)
STAG3Stromal antigen 3. (1125 aa)
PSME4Proteasome activator subunit 4. (1837 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (825 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (378 aa)
PDS5APDS5 cohesin associated factor A. (1331 aa)
PSMA2Proteasome endopeptidase complex. (156 aa)
SMC1BSMC hinge domain-containing protein. (705 aa)
K7GID7_PELSISMC_N domain-containing protein. (365 aa)
ANAPC16Anaphase promoting complex subunit 16. (111 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (543 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
RFC4Replication factor C subunit 4. (329 aa)
TCERG1LTranscription elongation regulator 1 like. (518 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (362 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (404 aa)
PSMF1PI31_Prot_C domain-containing protein. (174 aa)
RAD21L1RAD21 cohesin complex component like 1. (565 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (911 aa)
PSMA7Proteasome endopeptidase complex. (220 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (416 aa)
K7EXK2_PELSIUbiquitin-like domain-containing protein. (32 aa)
K7F1M4_PELSIUncharacterized protein. (56 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (809 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (548 aa)
K7F3C8_PELSIProteasome subunit alpha type. (245 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (416 aa)
PSMA8Proteasome endopeptidase complex. (194 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (371 aa)
CDK2Cyclin dependent kinase 2. (259 aa)
CDT1Chromatin licensing and DNA replication factor 1. (689 aa)
UBCUncharacterized protein. (355 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (393 aa)
K7F650_PELSIDNA primase; Belongs to the eukaryotic-type primase small subunit family. (382 aa)
PSMB6Proteasome subunit beta 6. (228 aa)
FAM89BFamily with sequence similarity 89 member B. (179 aa)
GINS1GINS complex subunit 1. (160 aa)
ORC5Origin recognition complex subunit 5. (447 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (426 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (141 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (114 aa)
ATAD5ATPase family AAA domain containing 5. (1692 aa)
ANAPC1Anaphase promoting complex subunit 1. (1341 aa)
STAG2Stromal antigen 2. (1040 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (439 aa)
ORC6Origin recognition complex subunit 6. (272 aa)
K7G5T8_PELSIDNA helicase; Belongs to the MCM family. (840 aa)
PSMA1Proteasome endopeptidase complex. (236 aa)
LOC102462305DNA helicase; Belongs to the MCM family. (812 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (437 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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