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| | RFC2 | Replication factor C subunit 2. (374 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2060 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3061 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (420 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (788 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (365 aa) |
| | PSMA4 | Proteasome subunit alpha type. (262 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (778 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (714 aa) |
| | RNF169 | Ring finger protein 169. (554 aa) |
| | RFC3 | Replication factor C subunit 3. (304 aa) |
| | CLSPN | Claspin. (1345 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (190 aa) |
| | PSMA6 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1517 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (482 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1831 aa) |
| | WEE1 | Wee1-like protein kinase. (510 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (323 aa) |
| | PSMB3 | Proteasome subunit beta. (204 aa) |
| | BLM | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (557 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (615 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (811 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (410 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (400 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (461 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1304 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2705 aa) |
| | PSMB2 | Proteasome subunit beta. (171 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (826 aa) |
| | KXD1 | KxDL motif containing 1. (176 aa) |
| | PSME4 | Proteasome activator subunit 4. (1837 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (552 aa) |
| | ORC3 | Origin recognition complex subunit 3. (724 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa) |
| | PSMA5 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (237 aa) |
| | K7G5T8_PELSI | DNA helicase; Belongs to the MCM family. (840 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1. (570 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1183 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1062 aa) |
| | EXO1 | Exonuclease 1. (808 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (140 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa) |
| | MEIOB | Meiosis specific with OB-fold. (467 aa) |
| | K7G262_PELSI | ANK_REP_REGION domain-containing protein. (93 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (231 aa) |
| | GTSE1 | Uncharacterized protein. (455 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (207 aa) |
| | YWHAB | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (288 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa) |
| | WRN | WRN RecQ like helicase. (1490 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (437 aa) |
| | LOC102462305 | DNA helicase; Belongs to the MCM family. (812 aa) |
| | TDRD3 | Tudor domain containing 3. (651 aa) |
| | PSMA1 | Proteasome endopeptidase complex. (236 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (494 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (825 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (378 aa) |
| | PSMA2 | Proteasome endopeptidase complex. (156 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2661 aa) |
| | RFC4 | Replication factor C subunit 4. (329 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1038 aa) |
| | CDCA7 | Cell division cycle associated 7. (274 aa) |
| | K7GEW4_PELSI | Piezo-type mechanosensitive ion channel component. (2540 aa) |
| | PSMF1 | PI31_Prot_C domain-containing protein. (174 aa) |
| | CHEK2 | Checkpoint kinase 2. (440 aa) |
| | PSMA7 | Proteasome endopeptidase complex. (220 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (616 aa) |
| | CHEK1 | Checkpoint kinase 1. (454 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (406 aa) |
| | ATRIP | ATR interacting protein. (519 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (865 aa) |
| | PSMD9 | PDZ domain-containing protein. (166 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (493 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa) |
| | WDR41 | WD repeat domain 41. (438 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (691 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (690 aa) |
| | ANKRD11 | ANK_REP_REGION domain-containing protein. (2723 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (144 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | BABAM1 | Uncharacterized protein. (224 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (439 aa) |
| | ORC6 | Origin recognition complex subunit 6. (272 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (250 aa) |
| | LOC102452578 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC102453087 | Histone H2B 8. (126 aa) |
| | LOC106732714 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa) |
| | K7EXN6_PELSI | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC102454071 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (109 aa) |
| | LOC102445301 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC102454821 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ANKRD31 | Uncharacterized protein. (300 aa) |
| | LOC102455573 | Histone H2B 8. (126 aa) |
| | LOC102455816 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (177 aa) |
| | LOC102444105 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPSIP00000001420 | annotation not available (103 aa) |
| | LOC102446769 | Histone H2B 8. (126 aa) |
| | LOC102448415 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (107 aa) |
| | LOC102448654 | Histone H4. (107 aa) |
| | ENSPSIP00000001542 | annotation not available (103 aa) |
| | LOC102450092 | Histone H4. (103 aa) |
| | LOC102450562 | Histone H4. (103 aa) |
| | LOC102450788 | Histone H4. (103 aa) |
| | LOC102451747 | Histone H2B 1/2/3/4/6. (126 aa) |
| | LOC102451988 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RMI1 | RecQ mediated genome instability 1. (623 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (809 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (548 aa) |
| | K7F3C8_PELSI | Proteasome subunit alpha type. (245 aa) |
| | CDC7 | Cell division cycle 7. (569 aa) |
| | PSMA8 | Proteasome endopeptidase complex. (194 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (371 aa) |
| | CDC45 | Cell division cycle 45. (596 aa) |
| | CDK2 | Cyclin dependent kinase 2. (259 aa) |
| | RECQL4 | Uncharacterized protein. (847 aa) |
| | UBC | Uncharacterized protein. (355 aa) |
| | RAD9B | Uncharacterized protein. (141 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (393 aa) |
| | PSMB6 | Proteasome subunit beta 6. (228 aa) |
| | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa) |
| | K7F7E8_PELSI | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | LOC102449128 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | ORC5 | Origin recognition complex subunit 5. (447 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (426 aa) |
| | ORC2 | Origin recognition complex subunit 2. (585 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | RPA3 | Replication protein A3. (119 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5. (228 aa) |
| | RFC5 | Replication factor C subunit 5. (319 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (244 aa) |
| | K7FC61_PELSI | BRCT_assoc domain-containing protein. (1048 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (230 aa) |
| | PSMD5 | Proteasome 26S subunit, non-ATPase 5. (453 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (714 aa) |
