46 items (Pelodiscus sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COP1	COP1 E3 ubiquitin ligase. (586 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (140 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (288 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (390 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (437 aa)
	PSMA1	Proteasome endopeptidase complex. (236 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (439 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMD9	PDZ domain-containing protein. (166 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (406 aa)
	PSMA7	Proteasome endopeptidase complex. (220 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (465 aa)
	PSMF1	PI31_Prot_C domain-containing protein. (174 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (473 aa)
	PSMA2	Proteasome endopeptidase complex. (156 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (378 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (323 aa)
	PSMA6	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (246 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (461 aa)
	K7EXK2_PELSI	Ubiquitin-like domain-containing protein. (32 aa)
	PSMB3	Proteasome subunit beta. (204 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	KXD1	KxDL motif containing 1. (176 aa)
	PSME4	Proteasome activator subunit 4. (1837 aa)
	PSMA5	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (237 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (426 aa)
	PSMB6	Proteasome subunit beta 6. (228 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (393 aa)
	UBC	Uncharacterized protein. (355 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (371 aa)
	PSMA8	Proteasome endopeptidase complex. (194 aa)
	K7F3C8_PELSI	Proteasome subunit alpha type. (245 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (809 aa)
	K7F0N6_PELSI	SWIB domain-containing protein. (130 aa)
	PSMB2	Proteasome subunit beta. (171 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (190 aa)
	PSMA4	Proteasome subunit alpha type. (262 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (365 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (420 aa)
	ATM	Non-specific serine/threonine protein kinase. (3061 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (453 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (230 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (244 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5. (228 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	COP1	ENSPSIP00000006822	ENSPSIP00000013274	Non-specific serine/threonine protein kinase.	COP1 E3 ubiquitin ligase.	0.649
ATM	K7F0N6_PELSI	ENSPSIP00000006822	ENSPSIP00000001596	Non-specific serine/threonine protein kinase.	SWIB domain-containing protein.	0.817
ATM	MDM2	ENSPSIP00000006822	ENSPSIP00000018492	Non-specific serine/threonine protein kinase.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.817
ATM	MDM4	ENSPSIP00000006822	ENSPSIP00000019027	Non-specific serine/threonine protein kinase.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.797
ATM	RPS27A	ENSPSIP00000006822	ENSPSIP00000014184	Non-specific serine/threonine protein kinase.	Ubiquitin-like domain-containing protein.	0.600
ATM	TP53	ENSPSIP00000006822	ENSPSIP00000014905	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.997
ATM	UBC	ENSPSIP00000006822	ENSPSIP00000003340	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.636
COP1	ATM	ENSPSIP00000013274	ENSPSIP00000006822	COP1 E3 ubiquitin ligase.	Non-specific serine/threonine protein kinase.	0.649
COP1	K7EXK2_PELSI	ENSPSIP00000013274	ENSPSIP00000000512	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.483
COP1	PSMC1	ENSPSIP00000013274	ENSPSIP00000016031	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.429
COP1	PSMC2	ENSPSIP00000013274	ENSPSIP00000015243	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.429
COP1	PSMC4	ENSPSIP00000013274	ENSPSIP00000017918	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.419
COP1	PSMC5	ENSPSIP00000013274	ENSPSIP00000004920	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 5.	0.429
COP1	PSMD14	ENSPSIP00000013274	ENSPSIP00000004574	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, non-ATPase 14.	0.432
COP1	PSMD4	ENSPSIP00000013274	ENSPSIP00000020275	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, non-ATPase 4.	0.413
COP1	PSMD7	ENSPSIP00000013274	ENSPSIP00000010426	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, non-ATPase 7.	0.417
COP1	PSMD9	ENSPSIP00000013274	ENSPSIP00000017671	COP1 E3 ubiquitin ligase.	PDZ domain-containing protein.	0.412
COP1	PSME4	ENSPSIP00000013274	ENSPSIP00000012552	COP1 E3 ubiquitin ligase.	Proteasome activator subunit 4.	0.475
COP1	RPS27A	ENSPSIP00000013274	ENSPSIP00000014184	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.632
COP1	TP53	ENSPSIP00000013274	ENSPSIP00000014905	COP1 E3 ubiquitin ligase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.839