(69 nodes) Signaling by Insulin receptor network (Pelodiscus sinensis)

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second shell of interactors

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proteins of unknown 3D structure

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	ATP6AP1L	ATPase H+ transporting accessory protein 1 like. (198 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
	ATP6V1D	ATPase H+ transporting V1 subunit D. (229 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (360 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
	LOC102443910	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1008 aa)
	ATP6V0D2	ATPase H+ transporting V0 subunit d2. (176 aa)
	ATP6V0E1	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	ATP6V1E1	Uncharacterized protein. (212 aa)
	K7G218_PELSI	TIR domain-containing protein; Belongs to the Toll-like receptor family. (1043 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	K7G0Z9_PELSI	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (792 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (864 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (934 aa)
	ATP6V0D1	ATPase H+ transporting V0 subunit d1. (364 aa)
	LOC102456381	Uncharacterized protein. (451 aa)
	K7FZH9_PELSI	Uncharacterized protein. (310 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (97 aa)
	FGF18	Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (204 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (250 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	LIM2	Lens intrinsic membrane protein 2. (173 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (559 aa)
	K7FTR4_PELSI	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (463 aa)
	FGFR3	Fibroblast growth factor receptor. (827 aa)
	NRDC	Uncharacterized protein; Belongs to the peptidase M16 family. (1149 aa)
	ATP6V1C1	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
	LOC102458989	Uncharacterized protein. (777 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	ATP6V1B2	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (502 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGFR2	Fibroblast growth factor receptor. (815 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	K7FJ02_PELSI	Phosphatidylinositol 3-kinase catalytic subunit type 3. (787 aa)
	K7FIQ5_PELSI	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (211 aa)
	FGFR1	Fibroblast growth factor receptor. (820 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (129 aa)
	CNST	Consortin, connexin sorting protein. (727 aa)
	LOC102447645	Uncharacterized protein. (227 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	GAB1	GRB2 associated binding protein 1. (687 aa)
	GAB2	GRB2 associated binding protein 2. (679 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (591 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1359 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	K7EZ34_PELSI	ATP-synt_ab domain-containing protein. (38 aa)
	K7EYG7_PELSI	Uncharacterized protein. (59 aa)
	TRIB3	Uncharacterized protein. (135 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (814 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ATP6V1A	ATPase H+ transporting V1 subunit A. (617 aa)
	ATP6V1H	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
	ATP6V1G1	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (135 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (359 aa)
	K7GDU5_PELSI	Uncharacterized protein. (167 aa)
	K7GDT8_PELSI	ATP-synt_ab domain-containing protein. (322 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	ATP6V1C2	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (386 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	ATP6V0A1	ENSPSIP00000016405	ENSPSIP00000018978	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.819
ATP6AP1	ATP6V0A2	ENSPSIP00000016405	ENSPSIP00000020076	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.761
ATP6AP1	ATP6V0A4	ENSPSIP00000016405	ENSPSIP00000017376	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.819
ATP6AP1	ATP6V0C	ENSPSIP00000016405	ENSPSIP00000006145	ATPase H+ transporting accessory protein 1.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.960
ATP6AP1	ATP6V0D1	ENSPSIP00000016405	ENSPSIP00000013629	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V0 subunit d1.	0.906
ATP6AP1	ATP6V0D2	ENSPSIP00000016405	ENSPSIP00000015395	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V0 subunit d2.	0.906
ATP6AP1	ATP6V0E1	ENSPSIP00000016405	ENSPSIP00000015209	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.952
ATP6AP1	ATP6V1A	ENSPSIP00000016405	ENSPSIP00000019267	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit A.	0.791
ATP6AP1	ATP6V1B2	ENSPSIP00000016405	ENSPSIP00000010255	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.899
ATP6AP1	ATP6V1C1	ENSPSIP00000016405	ENSPSIP00000010546	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.908
ATP6AP1	ATP6V1C2	ENSPSIP00000016405	ENSPSIP00000017740	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.885
ATP6AP1	ATP6V1D	ENSPSIP00000016405	ENSPSIP00000016553	ATPase H+ transporting accessory protein 1.	ATPase H+ transporting V1 subunit D.	0.947
ATP6AP1	ATP6V1E1	ENSPSIP00000016405	ENSPSIP00000014401	ATPase H+ transporting accessory protein 1.	Uncharacterized protein.	0.960
ATP6AP1	ATP6V1G1	ENSPSIP00000016405	ENSPSIP00000018778	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.958
ATP6AP1	ATP6V1H	ENSPSIP00000016405	ENSPSIP00000019173	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.964
ATP6AP1	CNST	ENSPSIP00000016405	ENSPSIP00000005930	ATPase H+ transporting accessory protein 1.	Consortin, connexin sorting protein.	0.796
ATP6AP1	K7EZ34_PELSI	ENSPSIP00000016405	ENSPSIP00000001044	ATPase H+ transporting accessory protein 1.	ATP-synt_ab domain-containing protein.	0.791
ATP6AP1	K7FTR4_PELSI	ENSPSIP00000016405	ENSPSIP00000011424	ATPase H+ transporting accessory protein 1.	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	0.899
ATP6AP1	K7G0Z9_PELSI	ENSPSIP00000016405	ENSPSIP00000013959	ATPase H+ transporting accessory protein 1.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.761
ATP6AP1	K7GDT8_PELSI	ENSPSIP00000016405	ENSPSIP00000018449	ATPase H+ transporting accessory protein 1.	ATP-synt_ab domain-containing protein.	0.791