(11 nodes) (2017) Outflow tract septation and the aortic arch system in reptiles: lessons for understanding the mammalian heart. network (Pelodiscus sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFAP2A	Transcription factor AP-2 alpha. (465 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	EDN1	Endothelin 1. (204 aa)
	LRP2	LDL receptor related protein 2. (4115 aa)
	KLF2	Uncharacterized protein. (385 aa)
	NKX2-5	NK2 homeobox 5. (272 aa)
	WT1	WT1 transcription factor. (415 aa)
	BMP4	Bone morphogenetic protein 4. (353 aa)
	K7FVT3_PELSI	Uncharacterized protein. (1020 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	PXDN	Peroxidasin. (1418 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGF8	ENSPSIP00000014414	ENSPSIP00000009052	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.611
BMP4	ISL1	ENSPSIP00000014414	ENSPSIP00000004923	Bone morphogenetic protein 4.	ISL LIM homeobox 1.	0.619
BMP4	LRP2	ENSPSIP00000014414	ENSPSIP00000017803	Bone morphogenetic protein 4.	LDL receptor related protein 2.	0.466
BMP4	NKX2-5	ENSPSIP00000014414	ENSPSIP00000016815	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.502
EDN1	FGF8	ENSPSIP00000004800	ENSPSIP00000009052	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.544
EDN1	KLF2	ENSPSIP00000004800	ENSPSIP00000017715	Endothelin 1.	Uncharacterized protein.	0.713
EDN1	LRP2	ENSPSIP00000004800	ENSPSIP00000017803	Endothelin 1.	LDL receptor related protein 2.	0.491
EDN1	NKX2-5	ENSPSIP00000004800	ENSPSIP00000016815	Endothelin 1.	NK2 homeobox 5.	0.526
EDN1	TFAP2A	ENSPSIP00000004800	ENSPSIP00000005480	Endothelin 1.	Transcription factor AP-2 alpha.	0.435
FGF8	BMP4	ENSPSIP00000009052	ENSPSIP00000014414	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.611
FGF8	EDN1	ENSPSIP00000009052	ENSPSIP00000004800	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Endothelin 1.	0.544
FGF8	LRP2	ENSPSIP00000009052	ENSPSIP00000017803	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LDL receptor related protein 2.	0.465
ISL1	BMP4	ENSPSIP00000004923	ENSPSIP00000014414	ISL LIM homeobox 1.	Bone morphogenetic protein 4.	0.619
ISL1	LRP2	ENSPSIP00000004923	ENSPSIP00000017803	ISL LIM homeobox 1.	LDL receptor related protein 2.	0.545
ISL1	NKX2-5	ENSPSIP00000004923	ENSPSIP00000016815	ISL LIM homeobox 1.	NK2 homeobox 5.	0.790
KLF2	EDN1	ENSPSIP00000017715	ENSPSIP00000004800	Uncharacterized protein.	Endothelin 1.	0.713
KLF2	LRP2	ENSPSIP00000017715	ENSPSIP00000017803	Uncharacterized protein.	LDL receptor related protein 2.	0.402
KLF2	TFAP2A	ENSPSIP00000017715	ENSPSIP00000005480	Uncharacterized protein.	Transcription factor AP-2 alpha.	0.402
LRP2	BMP4	ENSPSIP00000017803	ENSPSIP00000014414	LDL receptor related protein 2.	Bone morphogenetic protein 4.	0.466
LRP2	EDN1	ENSPSIP00000017803	ENSPSIP00000004800	LDL receptor related protein 2.	Endothelin 1.	0.491