STRINGSTRING
K7EWY9_PELSI K7EWY9_PELSI JUN JUN CLDN23 CLDN23 LOC102458879 LOC102458879 CLDN3 CLDN3 LOC102446947 LOC102446947 K7F0D9_PELSI K7F0D9_PELSI K7F0I3_PELSI K7F0I3_PELSI LOC102462467 LOC102462467 CLDN34 CLDN34 LOC102458580 LOC102458580 CLDN14 CLDN14 CLDN8 CLDN8 LOC102453465 LOC102453465 PCNA PCNA ARHGEF18 ARHGEF18 CLDN10 CLDN10 STK11 STK11 TUBA1B TUBA1B TUBA1C TUBA1C ACTR3 ACTR3 LOC102461661 LOC102461661 AFDN AFDN MYL6B MYL6B MYL6 MYL6 DLG2 DLG2 LOC102446337 LOC102446337 LOC102444749 LOC102444749 CACNA1D CACNA1D PPP2R1A PPP2R1A MYH11 MYH11 RAP1A RAP1A PRKAA2 PRKAA2 CTTN CTTN ACTN4 ACTN4 RAP2C RAP2C PPP2CA PPP2CA PARD6G PARD6G MAPK10 MAPK10 RAPGEF6 RAPGEF6 ARHGAP17 ARHGAP17 MICALL2 MICALL2 TJP1 TJP1 LOC102457934 LOC102457934 LOC102459140 LOC102459140 CGN CGN RAPGEF2 RAPGEF2 CLDN16 CLDN16 RAB8B RAB8B RDX RDX PATJ PATJ CLDN1 CLDN1 WHAMM WHAMM CLDN18 CLDN18 PRKACB PRKACB ACTR3B ACTR3B PRKCZ PRKCZ LOC102447673 LOC102447673 MAP3K1 MAP3K1 PPP2R2C PPP2R2C RAB8A RAB8A ACTR2 ACTR2 ROCK1 ROCK1 K7FM82_PELSI K7FM82_PELSI MARVELD3 MARVELD3 ACTN1 ACTN1 LOC102448096 LOC102448096 YBX3 YBX3 CGNL1 CGNL1 F11R F11R AMOT AMOT CCND1 CCND1 MPP4 MPP4 CLDN19 CLDN19 NEDD4L NEDD4L LOC102450833 LOC102450833 ROCK2 ROCK2 TJAP1 TJAP1 DLG3 DLG3 PRKCE PRKCE EPB41L4B EPB41L4B MYH9 MYH9 LOC102450295 LOC102450295 CLDN7 CLDN7 TJP2 TJP2 PARD3 PARD3 CLDN11 CLDN11 MPDZ MPDZ K7G0P6_PELSI K7G0P6_PELSI AMOTL1 AMOTL1 RAC1 RAC1 PRKCI PRKCI PRKAB2 PRKAB2 LLGL2 LLGL2 SRC SRC PPP2CB PPP2CB HSPA4 HSPA4 PRKACA PRKACA JAM2 JAM2 LOC102457243 LOC102457243 MYH10 MYH10 PRKAA1 PRKAA1 NF2 NF2 TJP3 TJP3 MSN MSN LOC102457342 LOC102457342 TIAM1 TIAM1 HCLS1 HCLS1 OCLN OCLN TUBA8 TUBA8 MPP5 MPP5 RHOA RHOA NEDD4 NEDD4 MAPK9 MAPK9 MAGI1 MAGI1 JAM3 JAM3 MAPK8 MAPK8 PPP2R2B PPP2R2B PARD6B PARD6B PPP2R2D PPP2R2D MAP3K5 MAP3K5 MYL9 MYL9 PPP2R2A PPP2R2A MAP2K7 MAP2K7 CFTR CFTR RUNX1 RUNX1 SCRIB SCRIB EZR EZR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
K7EWY9_PELSIClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)
CLDN23Claudin 23. (125 aa)
LOC102458879Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC102446947Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
K7F0D9_PELSIUncharacterized protein. (374 aa)
K7F0I3_PELSIUncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (307 aa)
LOC102462467Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (229 aa)
CLDN34Claudin 34. (207 aa)
LOC102458580Uncharacterized protein. (198 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
LOC102453465Actin gamma 1. (375 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
ARHGEF18Uncharacterized protein. (836 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (307 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (373 aa)
TUBA1BTubulin alpha 1b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (574 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (516 aa)
LOC102461661Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
AFDNAfadin, adherens junction formation factor. (1807 aa)
MYL6BUncharacterized protein. (153 aa)
MYL6Uncharacterized protein. (154 aa)
DLG2Discs large MAGUK scaffold protein 2. (634 aa)
LOC102446337Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
LOC102444749MARVEL domain-containing protein. (327 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2161 aa)
PPP2R1AUncharacterized protein. (175 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PRKAA2Non-specific serine/threonine protein kinase. (520 aa)
CTTNCortactin. (569 aa)
ACTN4Actinin alpha 4. (858 aa)
RAP2CRAP2C, member of RAS oncogene family. (134 aa)
PPP2CASerine/threonine-protein phosphatase. (244 aa)
PARD6GPar-6 family cell polarity regulator gamma. (384 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
RAPGEF6Uncharacterized protein. (1500 aa)
ARHGAP17Rho GTPase activating protein 17. (914 aa)
MICALL2MICAL like 2. (733 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1765 aa)
LOC102457934Uncharacterized protein. (172 aa)
LOC102459140Uncharacterized protein. (172 aa)
CGNUncharacterized protein. (1323 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1644 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (241 aa)
RAB8BRAB8B, member RAS oncogene family. (183 aa)
RDXRadixin. (583 aa)
PATJUncharacterized protein. (960 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (201 aa)
WHAMMWASP homolog associated with actin, golgi membranes and microtubules. (504 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (260 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (330 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
LOC102447673Ig-like domain-containing protein. (280 aa)
MAP3K1Protein kinase domain-containing protein. (247 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
RAB8ARAB8A, member RAS oncogene family. (180 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (391 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1358 aa)
K7FM82_PELSIIg-like domain-containing protein. (306 aa)
MARVELD3MARVEL domain-containing protein. (209 aa)
ACTN1Actinin alpha 1. (892 aa)
LOC102448096Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
YBX3Y-box binding protein 3. (214 aa)
CGNL1Cingulin like 1. (1296 aa)
F11RF11 receptor. (295 aa)
AMOTAngiomotin. (906 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
MPP4Membrane palmitoylated protein 4; Belongs to the MAGUK family. (604 aa)
CLDN19Claudin 19. (174 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (975 aa)
LOC102450833Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (194 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
TJAP1Uncharacterized protein. (540 aa)
DLG3Discs large MAGUK scaffold protein 3. (366 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (389 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
LOC102450295Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (414 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1221 aa)
PARD3Par-3 family cell polarity regulator. (1264 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (1712 aa)
K7G0P6_PELSIClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
AMOTL1Angiomotin like 1. (900 aa)
RAC1Rac family small GTPase 1. (186 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (607 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1026 aa)
SRCTyrosine-protein kinase. (533 aa)
PPP2CBSerine/threonine-protein phosphatase. (307 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (839 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (340 aa)
JAM2Junctional adhesion molecule 2. (304 aa)
LOC102457243FERM domain-containing protein. (644 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2005 aa)
PRKAA1Non-specific serine/threonine protein kinase. (560 aa)
NF2Neurofibromin 2. (328 aa)
TJP3Uncharacterized protein. (410 aa)
MSNMoesin. (580 aa)
LOC102457342Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (455 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1597 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (529 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (527 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (676 aa)
RHOAUncharacterized protein. (202 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1303 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1322 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
MAPK8Mitogen-activated protein kinase. (429 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
PARD6BPar-6 family cell polarity regulator beta. (373 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (455 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1218 aa)
MYL9Myosin light chain 9. (172 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (413 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (396 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1015 aa)
RUNX1Runt-related transcription factor. (459 aa)
SCRIBScribble planar cell polarity protein. (1464 aa)
EZREzrin. (600 aa)
Your Current Organism:
Pelodiscus sinensis
NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38
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