109 items (Pelodiscus sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP1R3D	Protein phosphatase 1 regulatory subunit 3D. (285 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (330 aa)
	LOC102460336	SH2 domain-containing protein. (241 aa)
	LOC102451702	Protein phosphatase 1 regulatory subunit. (303 aa)
	FOXO1	FOXO-TAD domain-containing protein. (401 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (150 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (284 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	INSR	Tyrosine-protein kinase receptor. (1338 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	MKNK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (471 aa)
	MAPK1	Mitogen-activated protein kinase. (322 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (349 aa)
	PYGM	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (901 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (520 aa)
	FBP2	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
	FBP1	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (254 aa)
	NRAS	NRAS proto-oncogene, GTPase. (123 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	PHKG2	Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (245 aa)
	LOC102447309	Uncharacterized protein. (208 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2445 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	K7FC24_PELSI	Uncharacterized protein. (295 aa)
	MAPK10	Mitogen-activated protein kinase. (426 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (714 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1302 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (397 aa)
	PYGL	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (889 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2522 aa)
	K7FJ02_PELSI	Phosphatidylinositol 3-kinase catalytic subunit type 3. (787 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (256 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	IRS4	Insulin receptor substrate 4. (1180 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (419 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (382 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	FASN	Fatty acid synthase. (2015 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	GYS2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (704 aa)
	TSC1	TSC complex subunit 1. (1168 aa)
	CALML6	Calmodulin like 6. (156 aa)
	PDE3B	Phosphodiesterase. (940 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	INPP5A	Inositol polyphosphate-5-phosphatase A. (388 aa)
	SOCS2	Suppressor of cytokine signaling 2. (159 aa)
	SH2B2	SH2B adaptor protein 2. (670 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (559 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2347 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (309 aa)
	LOC102456320	Uncharacterized protein. (217 aa)
	PHKG1	Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (388 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (760 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	SHC4	SHC adaptor protein 4. (633 aa)
	K7FY43_PELSI	Uncharacterized protein. (456 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (795 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (242 aa)
	PHKB	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1086 aa)
	CALML4	Calmodulin like 4. (153 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	CBL	Cbl proto-oncogene. (542 aa)
	IRS1	Insulin receptor substrate 1. (742 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (607 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
	TSC2	TSC complex subunit 2. (1816 aa)
	CALM3	Calmodulin 3; Belongs to the calmodulin family. (148 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1308 aa)
	CRK	CRK proto-oncogene, adaptor protein. (227 aa)
	PRKACA	Uncharacterized protein; Belongs to the protein kinase superfamily. (340 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (560 aa)
	K7G5M9_PELSI	Uncharacterized protein. (120 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
	HRAS	HRas proto-oncogene, GTPase. (190 aa)
	G6PC2	Glucose-6-phosphatase catalytic subunit 2. (358 aa)
	KRAS	KRAS proto-oncogene, GTPase. (227 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
	HK1	Hexokinase 1. (917 aa)
	MKNK2	MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (467 aa)
	LOC102456219	Uncharacterized protein; Belongs to the calmodulin family. (169 aa)
	RPS6KB2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (450 aa)
	CBLB	Cbl proto-oncogene B. (1031 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	HKDC1	Hexokinase domain containing 1. (896 aa)
	MAPK8	Mitogen-activated protein kinase. (429 aa)
	SHC3	SHC adaptor protein 3. (387 aa)
	PHKA2	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1237 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (359 aa)
	PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha. (304 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	HK2	Hexokinase 2. (913 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1245 aa)
	LOC102452499	Uncharacterized protein; Belongs to the calmodulin family. (151 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	CRKL	Uncharacterized protein. (194 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	LOC102449920	Serine/threonine-protein phosphatase. (266 aa)

Your Current Organism:

Pelodiscus sinensis

NCBI taxonomy Id: 13735
Other names: Chinese soft-shelled turtle, Chinese softshell turtle, P. sinensis, Trionyx sinensis, ZMB 38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSPSIP00000012716	ENSPSIP00000005262	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.901
ACACA	FASN	ENSPSIP00000012716	ENSPSIP00000011202	Acetyl-CoA carboxylase alpha.	Fatty acid synthase.	0.951
ACACA	PRKAA1	ENSPSIP00000012716	ENSPSIP00000015442	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.924
ACACA	PRKAA2	ENSPSIP00000012716	ENSPSIP00000003844	Acetyl-CoA carboxylase alpha.	Non-specific serine/threonine protein kinase.	0.924
ACACA	PRKAB2	ENSPSIP00000012716	ENSPSIP00000014466	Acetyl-CoA carboxylase alpha.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.913
ACACB	ACACA	ENSPSIP00000005262	ENSPSIP00000012716	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.901
ACACB	FASN	ENSPSIP00000005262	ENSPSIP00000011202	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.951
ACACB	PRKAA1	ENSPSIP00000005262	ENSPSIP00000015442	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.924
ACACB	PRKAA2	ENSPSIP00000005262	ENSPSIP00000003844	Acetyl-CoA carboxylase beta.	Non-specific serine/threonine protein kinase.	0.924
ACACB	PRKAB2	ENSPSIP00000005262	ENSPSIP00000014466	Acetyl-CoA carboxylase beta.	Protein kinase AMP-activated non-catalytic subunit beta 2.	0.913
AKT1	AKT3	ENSPSIP00000008474	ENSPSIP00000005472	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	CBLB	ENSPSIP00000008474	ENSPSIP00000017655	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cbl proto-oncogene B.	0.401
AKT1	FOXO1	ENSPSIP00000008474	ENSPSIP00000001176	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	FOXO-TAD domain-containing protein.	0.974
AKT1	GSK3B	ENSPSIP00000008474	ENSPSIP00000010018	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.954
AKT1	IKBKB	ENSPSIP00000008474	ENSPSIP00000005754	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.960
AKT1	INS	ENSPSIP00000008474	ENSPSIP00000013967	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.443
AKT1	K7FJ02_PELSI	ENSPSIP00000008474	ENSPSIP00000008012	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.948
AKT1	K7FY43_PELSI	ENSPSIP00000008474	ENSPSIP00000012953	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.949
AKT1	MAPK1	ENSPSIP00000008474	ENSPSIP00000003362	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.928
AKT1	MTOR	ENSPSIP00000008474	ENSPSIP00000007962	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.974