STRINGSTRING
pgi pgi AMW03849.1 AMW03849.1 AMW03859.1 AMW03859.1 AMW03861.1 AMW03861.1 AMW06483.1 AMW06483.1 AMW03961.1 AMW03961.1 AMW04041.1 AMW04041.1 AMW04101.1 AMW04101.1 AMW04102.1 AMW04102.1 AMW06527.1 AMW06527.1 AMW04212.1 AMW04212.1 accA accA AMW04306.1 AMW04306.1 AMW06552.1 AMW06552.1 AMW04310.1 AMW04310.1 pdhA pdhA gcvP gcvP gcvH gcvH AMW04350.1 AMW04350.1 AMW04360.1 AMW04360.1 AMW04361.1 AMW04361.1 AMW06583.1 AMW06583.1 AMW06596.1 AMW06596.1 tal tal AMW06606.1 AMW06606.1 prs prs AMW04672.1 AMW04672.1 AMW04680.1 AMW04680.1 AMW04701.1 AMW04701.1 AMW04702.1 AMW04702.1 AMW04705.1 AMW04705.1 glyA glyA eno eno fbp fbp AMW04890.1 AMW04890.1 sucD sucD sucC sucC AMW04937.1 AMW04937.1 sdhA sdhA mdh mdh tpiA tpiA pgk pgk AMW04945.1 AMW04945.1 AMW04964.1 AMW04964.1 AMW06711.1 AMW06711.1 AMW06717.1 AMW06717.1 accD accD AMW06722.1 AMW06722.1 AMW05013.1 AMW05013.1 folD folD AMW05038.1 AMW05038.1 AMW05067.1 AMW05067.1 AMW06739.1 AMW06739.1 aspA-2 aspA-2 AMW06750.1 AMW06750.1 AMW05134.1 AMW05134.1 AMW05227.1 AMW05227.1 pckA pckA ackA ackA AMW05287.1 AMW05287.1 AMW05332.1 AMW05332.1 AMW05333.1 AMW05333.1 AMW06809.1 AMW06809.1 AMW05334.1 AMW05334.1 AMW05335.1 AMW05335.1 AMW05336.1 AMW05336.1 AMW06810.1 AMW06810.1 gpmI gpmI AMW05408.1 AMW05408.1 gcvT gcvT AMW05430.1 AMW05430.1 acsA acsA acnA acnA AMW05552.1 AMW05552.1 AMW06866.1 AMW06866.1 AMW05675.1 AMW05675.1 pfkA pfkA fadJ fadJ fbp-2 fbp-2 AMW05995.1 AMW05995.1 AMW06093.1 AMW06093.1 AMW06114.1 AMW06114.1 AMW06145.1 AMW06145.1 fhs fhs ppc ppc AMW06231.1 AMW06231.1 AMW07014.1 AMW07014.1 AMW06333.1 AMW06333.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (547 aa)
AMW03849.1Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
AMW03859.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
AMW03861.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
AMW06483.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AMW03961.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (305 aa)
AMW04041.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (921 aa)
AMW04101.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
AMW04102.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa)
AMW06527.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
AMW04212.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa)
AMW04306.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
AMW06552.1Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (434 aa)
AMW04310.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
pdhADehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (339 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (968 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
AMW04350.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
AMW04360.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (222 aa)
AMW04361.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (294 aa)
AMW06583.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
AMW06596.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (376 aa)
AMW06606.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
AMW04672.1Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
AMW04680.1Lactoylglutathione lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
AMW04701.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
AMW04702.13-hydroxybutyryl-CoA dehydrogenase; Converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
AMW04705.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
fbpFructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (359 aa)
AMW04890.1Amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (436 aa)
sucDsuccinyl-CoA synthetase subsunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (381 aa)
AMW04937.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (637 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (309 aa)
tpiAHypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (398 aa)
AMW04945.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
AMW04964.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AMW06711.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
AMW06717.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (869 aa)
accDacetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
AMW06722.1Pyruvate carboxylase subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (510 aa)
AMW05013.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (512 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
AMW05038.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
AMW05067.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa)
AMW06739.1Hypothetical protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (165 aa)
aspA-2Aspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AMW06750.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
AMW05134.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa)
AMW05227.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (539 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (414 aa)
AMW05287.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
AMW05332.1Ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
AMW05333.12-oxoglutarate ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
AMW06809.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
AMW05334.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
AMW05335.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (917 aa)
AMW05336.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (76 aa)
AMW06810.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (519 aa)
AMW05408.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (370 aa)
AMW05430.1Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa)
AMW05552.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
AMW06866.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
AMW05675.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (770 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (359 aa)
fadJMultifunctional fatty acid oxidation complex subunit alpha; Multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (718 aa)
fbp-2Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (346 aa)
AMW05995.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
AMW06093.1Ribulose 1,5-bisphosphate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the RuBisCO large chain family. (427 aa)
AMW06114.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (470 aa)
AMW06145.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
fhsFormate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (561 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (927 aa)
AMW06231.1Serine--glyoxylate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AMW07014.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transketolase family. (675 aa)
AMW06333.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (155 aa)
Your Current Organism:
Gemmatimonas phototrophica
NCBI taxonomy Id: 1379270
Other names: DSM 29774, G. phototrophica, Gemmatimonas phototrophica Zeng et al. 2017, Gemmatimonas sp. AP64, MCCC 1K00455, strain AP64
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