STRINGSTRING
AKQ47378.1 AKQ47378.1 AKQ44452.1 AKQ44452.1 AKQ44453.1 AKQ44453.1 AKQ44455.1 AKQ44455.1 eno eno deoC deoC AKQ44589.1 AKQ44589.1 AKQ44595.1 AKQ44595.1 pgi pgi AKQ44752.1 AKQ44752.1 AKQ44879.1 AKQ44879.1 fmt fmt AKQ44922.1 AKQ44922.1 AKQ45061.1 AKQ45061.1 fbp fbp AKQ45145.1 AKQ45145.1 AKQ45148.1 AKQ45148.1 AKQ47504.1 AKQ47504.1 AKQ45160.1 AKQ45160.1 AKQ47505.1 AKQ47505.1 AKQ45228.1 AKQ45228.1 AKQ45229.1 AKQ45229.1 tal tal AKQ45262.1 AKQ45262.1 AKQ45363.1 AKQ45363.1 pckA pckA AKQ45509.1 AKQ45509.1 AKQ45579.1 AKQ45579.1 AKQ47561.1 AKQ47561.1 gltA gltA mqo mqo AKQ45700.1 AKQ45700.1 AKQ45771.1 AKQ45771.1 AKQ47588.1 AKQ47588.1 AKQ45791.1 AKQ45791.1 AKQ45796.1 AKQ45796.1 pdhA pdhA AKQ45797.1 AKQ45797.1 AKQ45798.1 AKQ45798.1 AKQ45845.1 AKQ45845.1 AKQ45868.1 AKQ45868.1 AKQ45870.1 AKQ45870.1 pfkA pfkA AKQ47610.1 AKQ47610.1 pgk pgk sucC sucC AKQ45967.1 AKQ45967.1 sdhA sdhA AKQ45969.1 AKQ45969.1 ackA ackA AKQ46015.1 AKQ46015.1 AKQ46037.1 AKQ46037.1 mdh mdh fbp-2 fbp-2 AKQ46299.1 AKQ46299.1 AKQ46345.1 AKQ46345.1 AKQ46472.1 AKQ46472.1 sucD sucD AKQ46700.1 AKQ46700.1 pdhA-2 pdhA-2 fumC fumC AKQ47098.1 AKQ47098.1 gpmI gpmI AKQ47149.1 AKQ47149.1 AKQ47210.1 AKQ47210.1 AKQ47268.1 AKQ47268.1 AKQ47285.1 AKQ47285.1 AKQ47286.1 AKQ47286.1 AKQ47287.1 AKQ47287.1 tpiA tpiA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKQ47378.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (757 aa)
AKQ44452.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AKQ44453.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
AKQ44455.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (461 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (219 aa)
AKQ44589.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (514 aa)
AKQ44595.1Sugar dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (552 aa)
AKQ44752.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (476 aa)
AKQ44879.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (313 aa)
AKQ44922.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
AKQ45061.1Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (858 aa)
fbpCatalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (329 aa)
AKQ45145.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (810 aa)
AKQ45148.1CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa)
AKQ47504.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
AKQ45160.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
AKQ47505.1Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1177 aa)
AKQ45228.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (572 aa)
AKQ45229.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (208 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (219 aa)
AKQ45262.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
AKQ45363.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (627 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
AKQ45509.1Tungsten formylmethanofuran dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (689 aa)
AKQ45579.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
AKQ47561.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (533 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
AKQ45700.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (803 aa)
AKQ45771.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
AKQ47588.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
AKQ45791.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (341 aa)
AKQ45796.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (322 aa)
AKQ45797.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
AKQ45798.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AKQ45845.1Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
AKQ45868.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
AKQ45870.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
AKQ47610.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (402 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
AKQ45967.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (637 aa)
AKQ45969.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
AKQ46015.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (701 aa)
AKQ46037.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
fbp-2Catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (342 aa)
AKQ46299.1acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (632 aa)
AKQ46345.12-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
AKQ46472.1Ribose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
AKQ46700.1Fructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
pdhA-2Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (348 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
AKQ47098.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
AKQ47149.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
AKQ47210.1Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (309 aa)
AKQ47268.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (659 aa)
AKQ47285.12-oxoglutarate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (919 aa)
AKQ47286.12-oxoglutarate dehydrogenase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (547 aa)
AKQ47287.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
Your Current Organism:
Rufibacter sp. DG31D
NCBI taxonomy Id: 1379910
Other names: R. sp. DG31D
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