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gcvH gcvH AKQ44879.1 AKQ44879.1 AKQ44893.1 AKQ44893.1 katE katE AKQ45063.1 AKQ45063.1 AKQ45424.1 AKQ45424.1 gltA gltA AKQ45796.1 AKQ45796.1 AKQ45826.1 AKQ45826.1 AKQ45959.1 AKQ45959.1 AKQ46036.1 AKQ46036.1 AKQ46098.1 AKQ46098.1 AKQ46113.1 AKQ46113.1 AKQ46194.1 AKQ46194.1 mdh mdh AKQ46250.1 AKQ46250.1 AKQ46252.1 AKQ46252.1 AKQ46281.1 AKQ46281.1 gcvT gcvT AKQ46299.1 AKQ46299.1 AKQ46628.1 AKQ46628.1 glyA glyA AKQ47192.1 AKQ47192.1 gcvP gcvP AKQ47287.1 AKQ47287.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
AKQ44879.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
AKQ44893.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
katEHydroperoxidase; Serves to protect cells from the toxic effects of hydrogen peroxide. (736 aa)
AKQ45063.1Ketohydroxyglutarate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
AKQ45424.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (730 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
AKQ45796.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
AKQ45826.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AKQ45959.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (757 aa)
AKQ46036.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (535 aa)
AKQ46098.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
AKQ46113.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AKQ46194.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
AKQ46250.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (611 aa)
AKQ46252.1methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (710 aa)
AKQ46281.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
AKQ46299.1acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (632 aa)
AKQ46628.1Hydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (294 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
AKQ47192.1Metal-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (971 aa)
AKQ47287.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
Your Current Organism:
Rufibacter sp. DG31D
NCBI taxonomy Id: 1379910
Other names: R. sp. DG31D
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