(19 nodes) Butanoate metabolism network (Rufibacter sp. DG31D)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	fabV	trans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (398 aa)
	AKQ45046.1	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
	AKQ45047.1	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
	AKQ47504.1	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	AKQ45160.1	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
	AKQ47505.1	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1177 aa)
	AKQ45273.1	succinyl-CoA:3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
	AKQ45275.1	succinyl-CoA:3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	AKQ45385.1	hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
	AKQ45438.1	3-hydroxybutyryl-CoA dehydrogenase; Converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
	AKQ45608.1	3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
	AKQ45826.1	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	AKQ47610.1	Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
	AKQ45967.1	Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	sdhA	Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (637 aa)
	AKQ45969.1	Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
	AKQ46113.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
	AKQ46872.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
	AKQ47307.1	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (800 aa)

Your Current Organism:

Rufibacter sp. DG31D

NCBI taxonomy Id: 1379910
Other names: R. sp. DG31D

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKQ45046.1	AKQ45047.1	TH63_04410	TH63_04415	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKQ45046.1	AKQ45160.1	TH63_04410	TH63_05155	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.944
AKQ45046.1	AKQ45385.1	TH63_04410	TH63_06620	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.601
AKQ45046.1	AKQ47307.1	TH63_04410	TH63_19325	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.414
AKQ45046.1	AKQ47504.1	TH63_04410	TH63_05150	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.918
AKQ45046.1	AKQ47505.1	TH63_04410	TH63_05160	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.961
AKQ45047.1	AKQ45046.1	TH63_04415	TH63_04410	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKQ45047.1	AKQ45160.1	TH63_04415	TH63_05155	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
AKQ45047.1	AKQ45385.1	TH63_04415	TH63_06620	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.850
AKQ45047.1	AKQ47504.1	TH63_04415	TH63_05150	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.906
AKQ45047.1	AKQ47505.1	TH63_04415	TH63_05160	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
AKQ45160.1	AKQ45046.1	TH63_05155	TH63_04410	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.944
AKQ45160.1	AKQ45047.1	TH63_05155	TH63_04415	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetohydroxyacid synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
AKQ45160.1	AKQ45385.1	TH63_05155	TH63_06620	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.941
AKQ45160.1	AKQ45826.1	TH63_05155	TH63_09525	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family.	0.924
AKQ45160.1	AKQ45969.1	TH63_05155	TH63_10470	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.628
AKQ45160.1	AKQ47307.1	TH63_05155	TH63_19325	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.445
AKQ45160.1	AKQ47504.1	TH63_05155	TH63_05150	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKQ45160.1	AKQ47505.1	TH63_05155	TH63_05160	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKQ45160.1	AKQ47610.1	TH63_05155	TH63_09985	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.844