STRINGSTRING
KXB85174.1 KXB85174.1 pyrB pyrB carA carA purD purD purU purU KXB84912.1 KXB84912.1 purC purC KXB84835.1 KXB84835.1 KXB84837.1 KXB84837.1 purT purT apt apt KXB83374.1 KXB83374.1 adk adk KXB83380.1 KXB83380.1 KXB83295.1 KXB83295.1 xpt xpt KXB82794.1 KXB82794.1 purE purE KXB82751.1 KXB82751.1 pyrE pyrE udk udk pyrD pyrD guaA guaA prs prs purA purA purL purL KXB79182.1 KXB79182.1 guaB guaB purN purN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KXB85174.1KEGG: pmz:HMPREF0659_A5881 1.4e-257 class II glutamine amidotransferase; K00764 amidophosphoribosyltransferase; Psort location: Cytoplasmic, score: 8.96. (628 aa)
pyrBKEGG: pru:PRU_0637 1.2e-146 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (315 aa)
carAKEGG: pmz:HMPREF0659_A5880 4.3e-176 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 9.97; Belongs to the CarA family. (358 aa)
purDKEGG: pru:PRU_1807 1.7e-190 purD; phosphoribosylamine--glycine ligase K01945; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family. (422 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
KXB84912.1ATP-grasp domain protein; KEGG: pmz:HMPREF0659_A5893 4.9e-104 ATP-grasp domain protein; K01955 carbamoyl-phosphate synthase large subunit; Psort location: Cytoplasmic, score: 8.96. (334 aa)
purCKEGG: pmz:HMPREF0659_A6716 2.0e-155 purC; phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family. (316 aa)
KXB84835.1Hypothetical protein; KEGG: pru:PRU_0720 1.3e-192 phosphoribosylformylglycinamidine cyclo-ligase; K01933 phosphoribosylformylglycinamidine cyclo-ligase; Psort location: Cytoplasmic, score: 9.97. (393 aa)
KXB84837.1KEGG: pit:PIN17_A1653 7.6e-115 pyrF; orotidine 5'-phosphate decarboxylase K01591; Psort location: Cytoplasmic, score: 8.96. (273 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (387 aa)
aptPutative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
KXB83374.1KEGG: pdn:HMPREF9137_0050 4.9e-72 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (198 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa)
KXB83380.1AICARFT/IMPCHase bienzyme; KEGG: pru:PRU_1927 2.9e-193 phosphoribosylaminoimidazolecarboxamide formyltransferase; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. (393 aa)
KXB83295.1Adenylosuccinate lyase; KEGG: pmz:HMPREF0659_A6153 2.3e-209 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97. (448 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
KXB82794.1MGS-like domain protein; KEGG: pru:PRU_1709 2.4e-88 IMP cyclohydrolase; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. (197 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
KXB82751.1KEGG: pit:PIN17_A0472 2.5e-84 ribF; riboflavin biosynthesis protein RibF K11753; Psort location: Cytoplasmic, score: 9.97. (311 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
udkUridine kinase; KEGG: pit:PIN17_A1417 6.6e-93 udk; uridine kinase K00876; Psort location: Cytoplasmic, score: 9.97. (211 aa)
pyrDDihydroorotate oxidase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (302 aa)
guaAGMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. (514 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
purLPutative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1240 aa)
KXB79182.1KEGG: pmz:HMPREF0659_A6372 2.8e-101 putative uracil phosphoribosyltransferase; K00761 uracil phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97. (219 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
purNPutative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa)
Your Current Organism:
Prevotella sp. DNF00663
NCBI taxonomy Id: 1384078
Other names: P. sp. DNF00663
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