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KXB85174.1 KXB85174.1 coaD coaD KXB78412.1 KXB78412.1 coaE coaE purN purN cmk cmk guaB guaB tdk tdk KXB79065.1 KXB79065.1 KXB79182.1 KXB79182.1 KXB79463.1 KXB79463.1 purL purL KXB80901.1 KXB80901.1 KXB81451.1 KXB81451.1 nadK nadK purA purA prs prs pyrG pyrG guaA guaA KXB82235.1 KXB82235.1 pyrD pyrD KXB82314.1 KXB82314.1 udk udk pyrE pyrE KXB82751.1 KXB82751.1 purE purE KXB82794.1 KXB82794.1 xpt xpt KXB83295.1 KXB83295.1 pyrH pyrH KXB83380.1 KXB83380.1 adk adk KXB83374.1 KXB83374.1 KXB83422.1 KXB83422.1 dut dut KXB83665.1 KXB83665.1 apt apt gmk gmk nadD nadD KXB84821.1 KXB84821.1 KXB84748.1 KXB84748.1 purT purT KXB84837.1 KXB84837.1 KXB84835.1 KXB84835.1 purC purC KXB84912.1 KXB84912.1 purU purU folD folD purD purD carA carA KXB85127.1 KXB85127.1 dacA dacA ackA ackA atpD atpD KXB85704.1 KXB85704.1 atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG KXB85666.1 KXB85666.1 nadE nadE pyrB pyrB pyrI pyrI KXB86008.1 KXB86008.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
KXB85174.1KEGG: pmz:HMPREF0659_A5881 1.4e-257 class II glutamine amidotransferase; K00764 amidophosphoribosyltransferase; Psort location: Cytoplasmic, score: 8.96. (628 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (153 aa)
KXB78412.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (506 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (189 aa)
purNPutative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa)
cmkCytidylate kinase; KEGG: pru:PRU_1828 4.5e-94 cmk; cytidylate kinase K00945; Psort location: Cytoplasmic, score: 9.97. (228 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
tdkThymidine kinase; KEGG: pmz:HMPREF0659_A5428 1.4e-74 tdk; thymidine kinase K00857; Psort location: Cytoplasmic, score: 9.97. (174 aa)
KXB79065.1Dihydroorotase; KEGG: pmz:HMPREF0659_A5999 5.9e-147 amidohydrolase family protein; K01465 dihydroorotase; Psort location: Cytoplasmic, score: 9.97. (443 aa)
KXB79182.1KEGG: pmz:HMPREF0659_A6372 2.8e-101 putative uracil phosphoribosyltransferase; K00761 uracil phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97. (219 aa)
KXB79463.1AMP-binding enzyme; KEGG: pdn:HMPREF9137_0471 2.8e-243 AMP-binding protein; K01895 acetyl-CoA synthetase; Psort location: Cytoplasmic, score: 9.26. (554 aa)
purLPutative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1240 aa)
KXB80901.1Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (402 aa)
KXB81451.1Putative pantothenate kinase; KEGG: pit:PIN17_A1404 1.4e-106 fumble domain protein; K09680 type II pantothenate kinase. (276 aa)
nadKNAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (297 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa)
guaAGMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. (514 aa)
KXB82235.1Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (292 aa)
pyrDDihydroorotate oxidase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (302 aa)
KXB82314.1KEGG: bhl:Bache_2300 2.0e-84 dihydroorotate oxidase B, electron transfer subunit K02823; Psort location: Cytoplasmic, score: 9.26. (258 aa)
udkUridine kinase; KEGG: pit:PIN17_A1417 6.6e-93 udk; uridine kinase K00876; Psort location: Cytoplasmic, score: 9.97. (211 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
KXB82751.1KEGG: pit:PIN17_A0472 2.5e-84 ribF; riboflavin biosynthesis protein RibF K11753; Psort location: Cytoplasmic, score: 9.97. (311 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
KXB82794.1MGS-like domain protein; KEGG: pru:PRU_1709 2.4e-88 IMP cyclohydrolase; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. (197 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
KXB83295.1Adenylosuccinate lyase; KEGG: pmz:HMPREF0659_A6153 2.3e-209 purB; adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 9.97. (448 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa)
KXB83380.1AICARFT/IMPCHase bienzyme; KEGG: pru:PRU_1927 2.9e-193 phosphoribosylaminoimidazolecarboxamide formyltransferase; K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase; Psort location: Cytoplasmic, score: 9.97. (393 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa)
KXB83374.1KEGG: pdn:HMPREF9137_0050 4.9e-72 hpt; hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (198 aa)
KXB83422.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa)
dutPutative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
KXB83665.1Hypothetical protein. (108 aa)
aptPutative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (396 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (187 aa)
KXB84821.1Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (349 aa)
KXB84748.1Hypothetical protein; KEGG: eel:EUBELI_01147 3.5e-39 cytidylate kinase; K00945 cytidylate kinase; Psort location: Cytoplasmic, score: 8.96. (212 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (387 aa)
KXB84837.1KEGG: pit:PIN17_A1653 7.6e-115 pyrF; orotidine 5'-phosphate decarboxylase K01591; Psort location: Cytoplasmic, score: 8.96. (273 aa)
KXB84835.1Hypothetical protein; KEGG: pru:PRU_0720 1.3e-192 phosphoribosylformylglycinamidine cyclo-ligase; K01933 phosphoribosylformylglycinamidine cyclo-ligase; Psort location: Cytoplasmic, score: 9.97. (393 aa)
purCKEGG: pmz:HMPREF0659_A6716 2.0e-155 purC; phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family. (316 aa)
KXB84912.1ATP-grasp domain protein; KEGG: pmz:HMPREF0659_A5893 4.9e-104 ATP-grasp domain protein; K01955 carbamoyl-phosphate synthase large subunit; Psort location: Cytoplasmic, score: 8.96. (334 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa)
purDKEGG: pru:PRU_1807 1.7e-190 purD; phosphoribosylamine--glycine ligase K01945; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family. (422 aa)
carAKEGG: pmz:HMPREF0659_A5880 4.3e-176 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 9.97; Belongs to the CarA family. (358 aa)
KXB85127.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (361 aa)
dacATIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (254 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (380 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (508 aa)
KXB85704.1ATP synthase, delta/epsilon subunit, beta-sandwich domain protein; KEGG: pru:PRU_1198 6.6e-22 ATP synthase F1 subunit epsilon; K02114 F-type H+-transporting ATPase subunit epsilon. (80 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (348 aa)
atpEPutative ATP synthase subunit c, sodium ion specific; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (80 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (172 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (528 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (323 aa)
KXB85666.1Competence/damage-inducible protein CinA domain protein; KEGG: cco:CCC13826_0279 4.2e-14 fadD; long-chain-fatty-acid--CoA ligase K03743; Psort location: Cytoplasmic, score: 8.96; Belongs to the CinA family. (170 aa)
nadENAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (646 aa)
pyrBKEGG: pru:PRU_0637 1.2e-146 pyrB; aspartate carbamoyltransferase K00609; Psort location: Cytoplasmic, score: 9.97; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (315 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (156 aa)
KXB86008.1WbqC-like protein; KEGG: fna:OOM_0806 1.5e-13 cysteine dioxygenase; Psort location: Cytoplasmic, score: 8.96. (204 aa)
Your Current Organism:
Prevotella sp. DNF00663
NCBI taxonomy Id: 1384078
Other names: P. sp. DNF00663
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