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| | AIZ62483.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (502 aa) |
| | purD | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (421 aa) |
| | purC | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (307 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (1011 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (188 aa) |
| | AIZ62488.1 | Hypothetical protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Belongs to the OMP decarboxylase family. Type 2 subfamily. (253 aa) |
| | AIZ62489.1 | Hypothetical protein; Catalyzes the conversion of dihydroorotate to orotate. (287 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (974 aa) |
| | aroK | Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | rocD | Ornithine--oxo-acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (400 aa) |
| | AIZ62578.1 | N-acyl-L-amino acid amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa) |
| | AIZ62595.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1239 aa) |
| | AIZ62596.1 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (318 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (224 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (430 aa) |
| | AIZ62716.1 | Cytochrome C4; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa) |
| | AIZ62717.1 | Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa) |
| | AIZ62718.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa) |
| | glmS | Glutamine amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (611 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (394 aa) |
| | AIZ62830.1 | GAF domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa) |
| | AIZ63007.1 | Colicin v production protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa) |
| | AIZ63008.1 | Aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa) |
| | AIZ63245.1 | Acetylornithine carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (314 aa) |
| | AIZ63247.1 | Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1078 aa) |
| | carA | Carbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (361 aa) |
| | AIZ63249.1 | Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (387 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (326 aa) |
| | AIZ63251.1 | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | AIZ63252.1 | Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (260 aa) |
| | AIZ63254.1 | Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa) |
| | AIZ63255.1 | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa) |
| | AIZ63323.1 | Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa) |
| | AIZ63368.1 | Cytochrome C4; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa) |
| | AIZ63369.1 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (347 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (407 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | aspA | Aspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa) |
| | aroB | Catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa) |
| | AIZ63627.1 | 1-alkyl-2-acetylglycerophosphocholine esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa) |
| | AIZ63660.1 | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa) |
| | AIZ63661.1 | Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa) |
| | AIZ63663.1 | Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (270 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa) |
| | AIZ63666.1 | 3-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa) |
| | AIZ63704.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | AIZ63797.1 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (433 aa) |
| | AIZ63806.1 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (353 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | folD | 5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa) |
| | AIZ63897.1 | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transferase hexapeptide repeat family. (271 aa) |
| | AIZ63943.1 | Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (434 aa) |
| | AIZ63945.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa) |
| | hisC | Histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa) |
| | AIZ63955.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (370 aa) |
| | hisH | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. (213 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | AIZ64052.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (729 aa) |
| | AIZ64062.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa) |
| | AIZ64125.1 | Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (313 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (425 aa) |
| | purE-2 | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (176 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (416 aa) |
| | carA-2 | Carbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (360 aa) |
| | AIZ64214.1 | Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1078 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (323 aa) |
| | AIZ64231.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa) |
| | AIZ64310.1 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (445 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (381 aa) |
| | AIZ64389.1 | Arginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (324 aa) |
| | AIZ64394.1 | Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) |
| | AIZ64437.1 | 3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (633 aa) |
| | AIZ64445.1 | Dihydrodipicolinate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapB family. (239 aa) |
| | gcvT | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa) |
| | AIZ64587.1 | Isoaspartyl peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa) |
| | AIZ64635.1 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (193 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa) |
| | guaB | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (264 aa) |
| | aroE | AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (420 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
