STRINGSTRING
AIZ62539.1 AIZ62539.1 aroK aroK AIZ62595.1 AIZ62595.1 gpmI gpmI trpF trpF AIZ62696.1 AIZ62696.1 glyA glyA AIZ62716.1 AIZ62716.1 AIZ62717.1 AIZ62717.1 AIZ62718.1 AIZ62718.1 AIZ62719.1 AIZ62719.1 AIZ62793.1 AIZ62793.1 AIZ64977.1 AIZ64977.1 AIZ63008.1 AIZ63008.1 tpiA tpiA AIZ63173.1 AIZ63173.1 AIZ63191.1 AIZ63191.1 AIZ63195.1 AIZ63195.1 AIZ63217.1 AIZ63217.1 AIZ63249.1 AIZ63249.1 argC argC AIZ63251.1 AIZ63251.1 argB argB AIZ63254.1 AIZ63254.1 AIZ63255.1 AIZ63255.1 AIZ63260.1 AIZ63260.1 AIZ63277.1 AIZ63277.1 AIZ63293.1 AIZ63293.1 AIZ63300.1 AIZ63300.1 AIZ63317.1 AIZ63317.1 AIZ63318.1 AIZ63318.1 AIZ63323.1 AIZ63323.1 AIZ63368.1 AIZ63368.1 AIZ63369.1 AIZ63369.1 aroA aroA AIZ65058.1 AIZ65058.1 AIZ63513.1 AIZ63513.1 pgk pgk aroB aroB AIZ63660.1 AIZ63660.1 AIZ63661.1 AIZ63661.1 trpD trpD AIZ63663.1 AIZ63663.1 trpB trpB trpA trpA AIZ63666.1 AIZ63666.1 AIZ63667.1 AIZ63667.1 AIZ65104.1 AIZ65104.1 AIZ63676.1 AIZ63676.1 tal tal AIZ63797.1 AIZ63797.1 AIZ63806.1 AIZ63806.1 aroQ aroQ AIZ63834.1 AIZ63834.1 proC proC dapA dapA gltA gltA AIZ63897.1 AIZ63897.1 AIZ63945.1 AIZ63945.1 AIZ63948.1 AIZ63948.1 hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI AIZ63991.1 AIZ63991.1 AIZ64018.1 AIZ64018.1 AIZ64052.1 AIZ64052.1 AIZ64125.1 AIZ64125.1 AIZ64149.1 AIZ64149.1 AIZ65192.1 AIZ65192.1 AIZ64173.1 AIZ64173.1 pfkA pfkA AIZ64194.1 AIZ64194.1 AIZ64260.1 AIZ64260.1 AIZ64310.1 AIZ64310.1 lysA lysA AIZ64324.1 AIZ64324.1 AIZ64389.1 AIZ64389.1 AIZ64437.1 AIZ64437.1 AIZ64445.1 AIZ64445.1 AIZ64516.1 AIZ64516.1 AIZ64596.1 AIZ64596.1 aroC aroC dapF dapF eno eno aroE aroE metK metK asd asd AIZ64816.1 AIZ64816.1 metXA metXA AIZ65309.1 AIZ65309.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIZ62539.1Alanine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
aroKHypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
AIZ62595.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1239 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (516 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (224 aa)
AIZ62696.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (430 aa)
AIZ62716.1Cytochrome C4; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
AIZ62717.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AIZ62718.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
AIZ62719.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AIZ62793.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AIZ64977.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (301 aa)
AIZ63008.1Aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
AIZ63173.1Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (320 aa)
AIZ63191.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
AIZ63195.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
AIZ63217.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AIZ63249.1Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (387 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (326 aa)
AIZ63251.1Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (260 aa)
AIZ63254.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
AIZ63255.1Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
AIZ63260.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AIZ63277.1Ribose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
AIZ63293.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (479 aa)
AIZ63300.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (362 aa)
AIZ63317.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
AIZ63318.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
AIZ63323.1Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa)
AIZ63368.1Cytochrome C4; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
AIZ63369.13-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (347 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (407 aa)
AIZ65058.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
AIZ63513.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (398 aa)
aroBCatalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
AIZ63660.1Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AIZ63661.1Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa)
AIZ63663.1Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (270 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
AIZ63666.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AIZ63667.1Phenylalanine-4-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AIZ65104.1Phenylalanine-4-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AIZ63676.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1174 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
AIZ63797.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (433 aa)
AIZ63806.1Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (353 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
AIZ63834.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
AIZ63897.12,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transferase hexapeptide repeat family. (271 aa)
AIZ63945.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
AIZ63948.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (232 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa)
hisCHistidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa)
hisBImidazoleglycerol-phosphate dehydratase; Catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (370 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisIphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. (213 aa)
AIZ63991.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa)
AIZ64018.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AIZ64052.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (729 aa)
AIZ64125.1Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (313 aa)
AIZ64149.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
AIZ65192.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
AIZ64173.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
AIZ64194.1Phosphoribosylpyrophosphate synthetase; Catalyzes the formation of PRPP from ATP and ribose 5-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribose-phosphate pyrophosphokinase family. (295 aa)
AIZ64260.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
AIZ64310.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (445 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (381 aa)
AIZ64324.1Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AIZ64389.1Arginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (324 aa)
AIZ64437.13-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (633 aa)
AIZ64445.1Dihydrodipicolinate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapB family. (239 aa)
AIZ64516.1Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
AIZ64596.1Fructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (264 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa)
aroEAroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (420 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa)
AIZ64816.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
metXAHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (343 aa)
AIZ65309.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
Your Current Organism:
Hymenobacter sp. DG25B
NCBI taxonomy Id: 1385664
Other names: H. sp. DG25B
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