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| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (772 aa) |
| | AGW42714.1 | Oligopeptide transporter; Belongs to the ABC transporter superfamily. (541 aa) |
| | dnaA | Chromosome replication initiator DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (457 aa) |
| | recF | Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (386 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (665 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (858 aa) |
| | AGW40307.1 | Serine/threonine kinase. (552 aa) |
| | AGW40308.1 | Serine/threonine kinase. (548 aa) |
| | AGW40318.1 | Multiple sugar transporter. (515 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (463 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (372 aa) |
| | AGW40424.1 | ABC transporter NBP/MSD fusion protein (pimaricin). (671 aa) |
| | AGW40425.1 | ABC transporter ATP-binding protein. (576 aa) |
| | AGW40428.1 | Transposase; Belongs to the DnaA family. (262 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (478 aa) |
| | AGW40445.1 | ABC transporter ATP binding protein. (233 aa) |
| | AGW40449.1 | ATP-dependent RNA helicase. (569 aa) |
| | AGW40457.1 | ABC transporter ATP-binding protein. (521 aa) |
| | AGW40460.1 | Uracil phosphoribosyltransferase. (128 aa) |
| | AGW40514.1 | ATP-dependent DNA helicase. (708 aa) |
| | AGW40538.1 | Mg++ transport, ATPase protein. (907 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (453 aa) |
| | AGW40551.1 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. (840 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (504 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (291 aa) |
| | AGW40561.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (178 aa) |
| | AGW40563.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (270 aa) |
| | folE | GTP cyclohydrolase I. (191 aa) |
| | ftsH | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (667 aa) |
| | tilS | Hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (358 aa) |
| | AGW40579.1 | Ferrous iron transport protein B. (633 aa) |
| | AGW40587.1 | ABC- transporter, ATP-binding protein. (228 aa) |
| | AGW40595.1 | ATP-dependent RNA helicase. (1565 aa) |
| | AGW40598.1 | ATP-dependent RNA helicase. (524 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1165 aa) |
| | AGW40612.1 | Guanylate kinase. (244 aa) |
| | AGW40621.1 | ABC-type Mn2+/Zn2+ transport systems, permease. (540 aa) |
| | fusA | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (704 aa) |
| | tuf | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (633 aa) |
| | AGW40635.1 | ABC transporter NBP/MSD fusion protein. (624 aa) |
| | ribA | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. (425 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (506 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (337 aa) |
| | AGW40664.1 | ABC transporter ATP-binding protein. (512 aa) |
| | AGW40677.1 | Biotin carboxylase. (586 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (372 aa) |
| | AGW40708.1 | Lipopolysaccharide exporter. (400 aa) |
| | coaA | Pantothenate kinase. (322 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (612 aa) |
| | AGW40731.1 | Hypothetical protein. (167 aa) |
| | AGW42715.1 | ABC transporter permease. (89 aa) |
| | groS | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (98 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (552 aa) |
| | AGW40750.1 | ATP-dependent DNA helicase II. (849 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa) |
| | AGW40782.1 | Hypothetical protein. (292 aa) |
| | AGW40800.1 | Capsular polysaccharide biosynthesis protein. (204 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (479 aa) |
| | AGW42736.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (457 aa) |
| | AGW40835.1 | Secreted protein. (141 aa) |
| | AGW40836.1 | Hypothetical protein. (433 aa) |
| | AGW40837.1 | Glycerol-phosphate porter; Belongs to the ABC transporter superfamily. (364 aa) |
| | AGW40847.1 | Hypothetical protein. (357 aa) |
| | groL | Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (539 aa) |
| | AGW40859.1 | DNA repair helicase. (546 aa) |
| | AGW40879.1 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (835 aa) |
| | AGW40888.1 | Glycine betaine/proline porter. (256 aa) |
| | AGW40890.1 | ATP-dependent RNA helicase. (1291 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | AGW40898.1 | Oleandomycin resistance ATPase. (605 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (315 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (529 aa) |
| | AGW40908.1 | RpiR family transcriptional regulator. (295 aa) |
| | murQ | N-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (304 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (901 aa) |
| | AGW40938.1 | Riboflavin kinase/ FMN adenyltransferase; Belongs to the ribF family. (314 aa) |
| | AGW40948.1 | Iron-vibriobactin/enterobactin uptake porter. (283 aa) |
| | AGW40949.1 | Hypothetical protein. (171 aa) |
| | AGW40951.1 | Hypothetical protein. (162 aa) |
| | AGW40954.1 | Cation-transporting P-type ATPase. (709 aa) |
| | AGW40957.1 | ATP-dependent RNA helicase. (721 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa) |
| | AGW40975.1 | ATP-dependent RNA helicase. (850 aa) |
| | AGW41009.1 | Chromosome partitioning protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (382 aa) |
| | AGW41016.1 | ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (493 aa) |
| | AGW41020.1 | ATP-dependent DNA helicase. (1040 aa) |
| | AGW41021.1 | ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1109 aa) |
| | AGW41026.1 | ATP-dependent DNA helicase II. (570 aa) |
| | AGW41028.1 | Secreted protein. (387 aa) |
| | AGW41030.1 | D-alanine:D-alanine ligase. (149 aa) |
| | AGW41038.1 | Hypothetical protein. (299 aa) |
| | AGW41041.1 | Lipopolysaccharide exporter. (244 aa) |
| | AGW41044.1 | ABC transporter ATP-binding protein. (342 aa) |
| | ftsE | ABC transporter ATP-binding protein; Part of the ABC transporter FtsEX involved in cellular division. (349 aa) |
| | AGW41054.1 | Cell division protein; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (301 aa) |
| | AGW41064.1 | ABC transporter ATP-binding protein. (153 aa) |
| | AGW41075.1 | Two-component system sensor protein. (541 aa) |
| | AGW41094.1 | Transposase. (262 aa) |
| | AGW41103.1 | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase. (227 aa) |
| | ddl | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (363 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (331 aa) |
| | AGW41121.1 | ATP-dependent DNA helicase RecG. (739 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | AGW41129.1 | ABC transporter ATP-binding protein. (227 aa) |
| | smc | Chromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1179 aa) |
| | ftsY | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (291 aa) |
| | ffh | Signal recognition particle subunit SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (524 aa) |
| | AGW41137.1 | Hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (389 aa) |
| | AGW41147.1 | Competence protein M. (431 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa) |
| | mnmA | tRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (360 aa) |
| | gatC | glutamyl-tRNA amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (105 aa) |
| | gatA | aspartyl/glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (515 aa) |
| | gatB | aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (499 aa) |
| | AGW41186.1 | ABC transporter ATP-binding protein. (499 aa) |
| | AGW41188.1 | Hypothetical protein. (207 aa) |
| | AGW41204.1 | DNA topoisomerase IV subunit B. (694 aa) |
| | AGW41205.1 | DNA topoisomerase IV subunit A. (823 aa) |
| | AGW41213.1 | Mn/Cd2+-ATPase, MntA. (791 aa) |
| | AGW41217.1 | ABC transporter ATP binding protein. (326 aa) |
| | AGW41226.1 | ATP/GTP-binding integral membrane protein. (350 aa) |
| | thrS | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (658 aa) |
| | pdxY | Pyridoxamine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (283 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (207 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (345 aa) |
| | AGW41257.1 | Recombination factor protein RarA. (428 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (885 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (166 aa) |
| | AGW41278.1 | Hypothetical protein. (175 aa) |
| | carA | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (383 aa) |
| | carB | Carbamoylphosphate synthase, large chain; Belongs to the CarB family. (1093 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (320 aa) |
| | AGW41284.1 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase. (431 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (87 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (279 aa) |
| | AGW41321.1 | Pyruvate kinase II; Belongs to the pyruvate kinase family. (481 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (688 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (968 aa) |
| | AGW41338.1 | Hypothetical protein; Displays ATPase and GTPase activities. (295 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (405 aa) |
| | AGW41349.1 | Glucose-6-phosphate isomerase; Belongs to the GPI family. (536 aa) |
| | AGW41358.1 | Multidrug resistance exporter. (264 aa) |
| | AGW41359.1 | Hypothetical protein. (109 aa) |
| | AGW41360.1 | ABC transporter ATP-binding protein. (532 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (414 aa) |
| | AGW41369.1 | ABC transporter ATP-binding protein. (266 aa) |
| | AGW41380.1 | UvrA-like protein. (479 aa) |
| | AGW41381.1 | UvrA-like protein. (150 aa) |
| | AGW41383.1 | Hypothetical protein. (611 aa) |
| | AGW41396.1 | Serine/threonine kinase. (472 aa) |
| | AGW41398.1 | Methanol dehydrogenase regulatory protein. (323 aa) |
| | AGW41404.1 | Transposase. (262 aa) |
| | AGW41461.1 | Oligopeptide transporter. (281 aa) |
| | AGW41462.1 | ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (562 aa) |
| | AGW41463.1 | ABC transporter permease. (351 aa) |
| | AGW41467.1 | Hypothetical protein. (152 aa) |
| | AGW41479.1 | ABC transporter ATP-binding protein. (243 aa) |
| | era | GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (297 aa) |
| | AGW41489.1 | Phosphate starvation-induced protein. (367 aa) |
| | dnaJ | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] (372 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (611 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (864 aa) |
| | AGW41506.1 | ABC transporter ATP-binding protein. (575 aa) |
| | AGW41507.1 | ABC transporter ATP-binding protein. (541 aa) |
| | AGW41516.1 | ABC-type glycine betaine transport, ATP-binding protein. (296 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (605 aa) |
| | AGW41532.1 | Transposase. (262 aa) |
| | AGW41534.1 | ATP-dependent RNA helicase. (811 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa) |
| | AGW41562.1 | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (235 aa) |
| | obg | GTPase ObgE; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (514 aa) |
| | AGW41569.1 | Nucleoside diphosphate kinase. (140 aa) |
| | AGW41571.1 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (455 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1074 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner. (871 aa) |
| | clpX | ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa) |
| | AGW41594.1 | ABC transporter ATP-binding protein. (295 aa) |
| | AGW41595.1 | ABC transporter integral membrane subunit. (277 aa) |
| | AGW41607.1 | ABC transporter ATP-binding protein. (560 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (279 aa) |
| | AGW41621.1 | UDP-N-acetylmuramyl tripeptide synthetase. (424 aa) |
| | glnE | Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (1007 aa) |
| | AGW41650.1 | Dihydroxyacetone kinase. (333 aa) |
| | nrdR | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (157 aa) |
| | AGW41668.1 | Flavin-dependent reductase. (171 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (391 aa) |
| | murC | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (470 aa) |
| | murD | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (517 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (475 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (514 aa) |
| | AGW41692.1 | Serine/threonine kinase. (633 aa) |
| | AGW41698.1 | Hypothetical protein. (436 aa) |
| | AGW41699.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1134 aa) |
| | AGW41700.1 | Plasmid partitioning protein. (272 aa) |
| | AGW41745.1 | Hypothetical protein. (946 aa) |
| | AGW41770.1 | Heat shock protein. (318 aa) |
| | metN | Glycine betaine/proline porter; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (340 aa) |
| | AGW41842.1 | ABC-type glycine betaine transport, ATP-binding protein. (430 aa) |
| | AGW41849.1 | Hypothetical protein. (380 aa) |
| | AGW41851.1 | Hypothetical protein. (82 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (504 aa) |
| | hflX | GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (503 aa) |
| | AGW41871.1 | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (257 aa) |
| | recA | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (357 aa) |
| | AGW41880.1 | Cell division protein. (927 aa) |
| | AGW41902.1 | GTP-binding protein elongation factor. (638 aa) |
| | AGW41903.1 | ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily. (551 aa) |
| | AGW41904.1 | ABC transporter permease. (311 aa) |
| | AGW41910.1 | Oligopeptide transporter; Belongs to the ABC transporter superfamily. (619 aa) |
| | AGW41912.1 | ABC transporter permease. (336 aa) |
| | ychF | GTP-dependent nucleic acid-binding protein EngD; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (357 aa) |
| | AGW41949.1 | PhoH-like protein. (449 aa) |
| | AGW41983.1 | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (431 aa) |
| | AGW41986.1 | Nucleoside triphosphate pyrophosphohydrolase. (215 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1203 aa) |
| | AGW41991.1 | Shikimate kinase I. (96 aa) |
| | AGW42010.1 | Hypothetical protein. (185 aa) |
| | atpD | ATP synthase F0F1 subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (487 aa) |
| | atpG | ATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (299 aa) |
| | atpA | ATP synthase F0F1 subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (551 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (697 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (330 aa) |
| | argS | arginyl-tRNA synthetase. (562 aa) |
| | AGW42074.1 | Hypothetical protein. (339 aa) |
| | AGW42075.1 | Elongation factor Tu. (81 aa) |
| | AGW42084.1 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (194 aa) |
| | der | GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (501 aa) |
| | cmk | Cytidylate kinase. (227 aa) |
| | AGW42112.1 | Hypothetical protein. (204 aa) |
| | AGW42114.1 | Chromosome partitioning protein. (299 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (574 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (308 aa) |
| | AGW42122.1 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (579 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (442 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | AGW42142.1 | Hypothetical protein. (538 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (849 aa) |
| | pheS | phenylalanyl-tRNA synthetase subunit alpha; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (346 aa) |
| | AGW42151.1 | ABC transporter ATP-binding protein. (211 aa) |
| | AGW42152.1 | Hypothetical protein. (352 aa) |
| | AGW42177.1 | Serine/threonine kinase. (413 aa) |
| | nnrD | Hypothetical protein; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (282 aa) |
| | rsgA | Hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (352 aa) |
| | AGW42195.1 | Oligopeptide transporter. (255 aa) |
| | AGW42196.1 | ABC transporter ATP-binding protein. (226 aa) |
| | AGW42197.1 | ABC transporter permease. (253 aa) |
| | secA | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (938 aa) |
| | AGW42211.1 | Two-component system sensor protein. (540 aa) |
| | AGW42214.1 | Hypothetical protein. (206 aa) |
| | AGW42216.1 | Secreted protein. (193 aa) |
| | AGW42217.1 | Methanol dehydrogenase regulatory protein. (331 aa) |
| | pstB | Phosphate transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (259 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (195 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | AGW42331.1 | Hypothetical protein. (341 aa) |
| | acsA | O-succinylbenzoate-CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa) |
| | AGW42342.1 | Thymidine kinase. (224 aa) |
| | AGW42349.1 | Aspartate kinase; Belongs to the aspartokinase family. (428 aa) |
| | AGW42351.1 | DNA polymerase III subunits gamma and tau. (823 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | AGW42360.1 | ABC transporter NBP/MSD fusion protein. (365 aa) |
| | AGW42375.1 | ABC transporter NBP/MSD fusion protein. (623 aa) |
| | AGW42391.1 | Lipoprotein translocation system. (223 aa) |
| | AGW42404.1 | LuxR family transcriptional regulator. (651 aa) |
| | AGW42406.1 | Asparagine synthase. (576 aa) |
| | AGW42421.1 | Oleandomycin resistance ATPase. (149 aa) |
| | AGW42426.1 | ATP-dependent DNA helicase. (668 aa) |
| | AGW42429.1 | ABC transporter ATP-binding protein. (543 aa) |
| | AGW42431.1 | Cobalt ABC transporter permease. (79 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | AGW42517.1 | aspartyl/glutamyl-tRNA amidotransferase subunit B; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (400 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (445 aa) |
| | AGW42563.1 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. (717 aa) |
| | dnaK | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (624 aa) |
| | AGW42597.1 | Hypothetical protein. (161 aa) |
| | AGW42598.1 | Hypothetical protein; Belongs to the RimK family. (391 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (417 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (290 aa) |
| | AGW42614.1 | Phosphoribosylformylglycinamidine synthase. (77 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (232 aa) |
| | AGW42644.1 | Methanol dehydrogenase regulatory protein. (273 aa) |
| | AGW42647.1 | Serine/threonine kinase. (319 aa) |
| | AGW42651.1 | ATP-dependent Clp protease, ATP-binding subunit. (441 aa) |
| | AGW42652.1 | Hypothetical protein. (337 aa) |
| | AGW42660.1 | ABC transporter ATP-binding protein. (286 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (438 aa) |
