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AKJ08_0065 AKJ08_0065 AKJ08_0080 AKJ08_0080 AKJ08_0081 AKJ08_0081 AKJ08_0146 AKJ08_0146 AKJ08_0147 AKJ08_0147 pfkA pfkA AKJ08_0154 AKJ08_0154 AKJ08_0155 AKJ08_0155 AKJ08_0191 AKJ08_0191 gcvPA gcvPA gcvH gcvH gcvT gcvT AKJ08_0307 AKJ08_0307 AKJ08_0379 AKJ08_0379 AKJ08_0448 AKJ08_0448 AKJ08_0452 AKJ08_0452 AKJ08_0469 AKJ08_0469 AKJ08_0517 AKJ08_0517 AKJ08_0623 AKJ08_0623 AKJ08_0645 AKJ08_0645 AKJ08_0646 AKJ08_0646 AKJ08_0647 AKJ08_0647 deoC deoC AKJ08_0730 AKJ08_0730 AKJ08_0731 AKJ08_0731 pgi pgi pfkA-2 pfkA-2 AKJ08_0798 AKJ08_0798 AKJ08_0799 AKJ08_0799 AKJ08_0845 AKJ08_0845 pgk pgk tpiA tpiA AKJ08_0904 AKJ08_0904 eno eno AKJ08_1059 AKJ08_1059 AKJ08_1374 AKJ08_1374 AKJ08_1398 AKJ08_1398 AKJ08_1399 AKJ08_1399 sucC sucC AKJ08_1401 AKJ08_1401 AKJ08_1402 AKJ08_1402 AKJ08_1403 AKJ08_1403 mdh mdh AKJ08_1405 AKJ08_1405 AKJ08_1407 AKJ08_1407 AKJ08_1580 AKJ08_1580 AKJ08_1581 AKJ08_1581 pdhA pdhA glyA glyA AKJ08_1628 AKJ08_1628 AKJ08_1808 AKJ08_1808 AKJ08_1829 AKJ08_1829 AKJ08_1864 AKJ08_1864 AKJ08_1878 AKJ08_1878 AKJ08_1882 AKJ08_1882 AKJ08_1884 AKJ08_1884 AKJ08_2017 AKJ08_2017 AKJ08_2103 AKJ08_2103 AKJ08_2104 AKJ08_2104 lipB lipB AKJ08_2120 AKJ08_2120 AKJ08_2121 AKJ08_2121 AKJ08_2122 AKJ08_2122 lipA lipA AKJ08_2124 AKJ08_2124 tal tal AKJ08_2180 AKJ08_2180 prs prs gpmI gpmI AKJ08_2723 AKJ08_2723 AKJ08_2818 AKJ08_2818 AKJ08_3009 AKJ08_3009 fumC fumC AKJ08_3012 AKJ08_3012 AKJ08_3164 AKJ08_3164 AKJ08_3175 AKJ08_3175 AKJ08_3223 AKJ08_3223
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AKJ08_0065Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (354 aa)
AKJ08_00802-oxoglutarate oxidoreductase, beta subunit. (332 aa)
AKJ08_00812-oxoglutarate oxidoreductase, alpha subunit. (617 aa)
AKJ08_0146Fumarate hydratase class I, aerobic. (208 aa)
AKJ08_0147Fumarate hydratase class I, aerobic. (419 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (345 aa)
AKJ08_0154Isocitrate dehydrogenase. (333 aa)
AKJ08_0155Folate-dependent protein for Fe/S cluster synthesis/repair in oxidative stress; Belongs to the GcvT family. (358 aa)
AKJ08_0191Glycine dehydrogenase [decarboxylating] (glycine cleavage system P2 protein). (441 aa)
gcvPAGlycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (439 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
gcvTAminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
AKJ08_0307Fructose-bisphosphate aldolase class I. (308 aa)
AKJ08_0379Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (786 aa)
AKJ08_0448Aconitate hydratase; Belongs to the LeuD family. (213 aa)
AKJ08_0452Aconitate hydratase. (654 aa)
AKJ08_0469NADP-dependent malic enzyme. (761 aa)
AKJ08_0517Aconitate hydratase. (754 aa)
AKJ08_0623Pyruvate oxidase; Belongs to the TPP enzyme family. (594 aa)
AKJ08_06452-oxoglutarate dehydrogenase E1 component. (937 aa)
AKJ08_0646Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa)
AKJ08_0647Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (466 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (234 aa)
AKJ08_0730Transketolase. (291 aa)
AKJ08_0731Transketolase. (317 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (457 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (362 aa)
AKJ08_0798Sarcosine oxidase beta subunit. (508 aa)
AKJ08_0799Sarcosine oxidase alpha subunit. (442 aa)
AKJ08_0845NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
AKJ08_0904D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
AKJ08_1059Phosphoglyceromutase. (306 aa)
AKJ08_1374Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (547 aa)
AKJ08_1398Succinyl-CoA ligase [ADP-forming] alpha chain. (145 aa)
AKJ08_1399Succinyl-CoA ligase [ADP-forming] alpha chain. (172 aa)
sucCSuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa)
AKJ08_1401Succinate dehydrogenase iron-sulfur protein. (262 aa)
AKJ08_1402Succinate dehydrogenase flavoprotein subunit. (637 aa)
AKJ08_1403Succinate dehydrogenase cytochrome b subunit. (239 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
AKJ08_1405Isocitrate dehydrogenase. (419 aa)
AKJ08_1407Pyruvate kinase; Belongs to the pyruvate kinase family. (466 aa)
AKJ08_1580Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (568 aa)
AKJ08_1581Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (338 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
AKJ08_1628Ribose 5-phosphate isomerase B. (149 aa)
AKJ08_1808Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (539 aa)
AKJ08_1829Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (887 aa)
AKJ08_1864Threonine dehydratase. (402 aa)
AKJ08_18782-isopropylmalate synthase. (420 aa)
AKJ08_18823-isopropylmalate dehydrogenase. (355 aa)
AKJ08_18843-isopropylmalate dehydratase large subunit. (655 aa)
AKJ08_2017Branched-chain amino acid aminotransferase. (354 aa)
AKJ08_2103Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (335 aa)
AKJ08_2104Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (351 aa)
lipBOctanoate-[acyl-carrier-protein]-protein-N- octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (361 aa)
AKJ08_2120Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (416 aa)
AKJ08_2121Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (417 aa)
AKJ08_2122Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (327 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa)
AKJ08_2124Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (467 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
AKJ08_2180Low-specificity L-threonine aldolase. (342 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (518 aa)
AKJ08_2723Glucokinase. (324 aa)
AKJ08_2818Citrate synthase (si); Belongs to the citrate synthase family. (383 aa)
AKJ08_3009Succinate-semialdehyde dehydrogenase. (465 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (471 aa)
AKJ08_3012NAD-dependent malic enzyme. (544 aa)
AKJ08_3164D-glycerate 2-kinase. (425 aa)
AKJ08_3175Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (222 aa)
AKJ08_3223Glucose 1-dehydrogenase. (381 aa)
Your Current Organism:
Vulgatibacter incomptus
NCBI taxonomy Id: 1391653
Other names: Cystobacteraceae bacterium B00001, DSM 27710, NBRC 109945, V. incomptus, Vulgatibacter incomptus Yamamoto et al. 2014, strain B00001
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