32 items (Sporothrix schenckii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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	U7PHU5_SPOS1	ERCC4 domain-containing protein. (592 aa)
	U7PJH8_SPOS1	Asparagine-tRNA ligase. (593 aa)
	U7PKL1_SPOS1	DRMBL domain-containing protein. (949 aa)
	U7PKL3_SPOS1	XPGI domain-containing protein. (299 aa)
	U7PL29_SPOS1	RECA_2 domain-containing protein. (637 aa)
	U7PMG1_SPOS1	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (495 aa)
	U7PMR1_SPOS1	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
	U7PNX6_SPOS1	AAA_23 domain-containing protein. (1331 aa)
	U7PPB0_SPOS1	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (814 aa)
	U7PPJ9_SPOS1	BRCT domain-containing protein. (1437 aa)
	U7PQV4_SPOS1	Uncharacterized protein. (1870 aa)
	U7PSZ7_SPOS1	Uncharacterized protein. (1800 aa)
	U7PTD5_SPOS1	Uncharacterized protein. (286 aa)
	U7PV83_SPOS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2111 aa)
	U7PXL6_SPOS1	Uncharacterized protein. (1304 aa)
	U7PY10_SPOS1	DNA_LIGASE_A3 domain-containing protein. (1021 aa)
	U7PYT6_SPOS1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (669 aa)
	U7PYX8_SPOS1	SAP domain-containing protein. (736 aa)
	U7PYY3_SPOS1	Uncharacterized protein. (1106 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (485 aa)
	U7Q0J8_SPOS1	FHA domain-containing protein. (992 aa)
	U7Q0Q0_SPOS1	VWFA domain-containing protein. (744 aa)
	U7Q290_SPOS1	Uncharacterized protein. (912 aa)
	U7Q2D7_SPOS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3901 aa)
	U7Q2G7_SPOS1	3'-5' exonuclease domain-containing protein. (579 aa)
	U7Q4G5_SPOS1	zf-GRF domain-containing protein. (644 aa)
	U7Q4H2_SPOS1	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (628 aa)
	U7Q4P6_SPOS1	Uncharacterized protein. (1718 aa)
	U7Q624_SPOS1	DNA repair protein rhp54. (681 aa)
	U7Q6A5_SPOS1	DUF1767 domain-containing protein. (251 aa)
	U7Q6E5_SPOS1	RECA_2 domain-containing protein. (493 aa)
	U7Q7L9_SPOS1	Uncharacterized protein. (912 aa)

Your Current Organism:

Sporothrix schenckii

NCBI taxonomy Id: 1391915
Other names: S. schenckii ATCC 58251, Sporothrix schenckii ATCC 58251

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SLX1	U7PHU5_SPOS1	U7PZZ5	U7PHU5	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	ERCC4 domain-containing protein.	0.877
SLX1	U7PJH8_SPOS1	U7PZZ5	U7PJH8	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Asparagine-tRNA ligase.	0.979
SLX1	U7PKL1_SPOS1	U7PZZ5	U7PKL1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DRMBL domain-containing protein.	0.688
SLX1	U7PKL3_SPOS1	U7PZZ5	U7PKL3	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	XPGI domain-containing protein.	0.816
SLX1	U7PL29_SPOS1	U7PZZ5	U7PL29	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	RECA_2 domain-containing protein.	0.734
SLX1	U7PMG1_SPOS1	U7PZZ5	U7PMG1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.919
SLX1	U7PMR1_SPOS1	U7PZZ5	U7PMR1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.815
SLX1	U7PPJ9_SPOS1	U7PZZ5	U7PPJ9	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	BRCT domain-containing protein.	0.621
SLX1	U7PQV4_SPOS1	U7PZZ5	U7PQV4	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein.	0.919
SLX1	U7PSZ7_SPOS1	U7PZZ5	U7PSZ7	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein.	0.817
SLX1	U7PV83_SPOS1	U7PZZ5	U7PV83	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.457
SLX1	U7PY10_SPOS1	U7PZZ5	U7PY10	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA_LIGASE_A3 domain-containing protein.	0.485
SLX1	U7PYT6_SPOS1	U7PZZ5	U7PYT6	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.871
SLX1	U7Q290_SPOS1	U7PZZ5	U7Q290	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein.	0.649
SLX1	U7Q2D7_SPOS1	U7PZZ5	U7Q2D7	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.710
SLX1	U7Q2G7_SPOS1	U7PZZ5	U7Q2G7	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	3'-5' exonuclease domain-containing protein.	0.995
SLX1	U7Q4G5_SPOS1	U7PZZ5	U7Q4G5	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	zf-GRF domain-containing protein.	0.829
SLX1	U7Q4P6_SPOS1	U7PZZ5	U7Q4P6	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	Uncharacterized protein.	0.713
SLX1	U7Q624_SPOS1	U7PZZ5	U7Q624	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DNA repair protein rhp54.	0.524
SLX1	U7Q6A5_SPOS1	U7PZZ5	U7Q6A5	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	DUF1767 domain-containing protein.	0.873