66 items (Sporothrix schenckii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	U7Q8B6_SPOS1	Uncharacterized protein. (1135 aa)
	U7PH59_SPOS1	Uncharacterized protein. (588 aa)
	U7PH72_SPOS1	Uncharacterized protein. (583 aa)
	U7PHU5_SPOS1	ERCC4 domain-containing protein. (592 aa)
	U7PJD6_SPOS1	Uncharacterized protein. (536 aa)
	U7PJF7_SPOS1	Serine/threonine protein kinase. (688 aa)
	U7PJH8_SPOS1	Asparagine-tRNA ligase. (593 aa)
	U7PJT5_SPOS1	Uncharacterized protein. (369 aa)
	U7PK70_SPOS1	Serine/threonine-protein phosphatase. (476 aa)
	U7PKN4_SPOS1	Cyclin N-terminal domain-containing protein. (457 aa)
	U7PKR8_SPOS1	ERCC4 domain-containing protein. (876 aa)
	U7PL29_SPOS1	RECA_2 domain-containing protein. (637 aa)
	U7PMA4_SPOS1	CAMK protein kinase. (1448 aa)
	U7PMG1_SPOS1	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (495 aa)
	U7PMR1_SPOS1	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (353 aa)
	U7PN00_SPOS1	Uncharacterized protein. (588 aa)
	U7PNJ4_SPOS1	Uncharacterized protein. (526 aa)
	U7PNX6_SPOS1	AAA_23 domain-containing protein. (1331 aa)
	U7PPA9_SPOS1	Uncharacterized protein. (215 aa)
	U7PPB0_SPOS1	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (814 aa)
	U7PQH5_SPOS1	FHA domain-containing protein. (908 aa)
	U7PQK6_SPOS1	RAN protein kinase. (732 aa)
	U7PQL3_SPOS1	CAMK protein kinase. (1027 aa)
	U7PQV4_SPOS1	Uncharacterized protein. (1870 aa)
	U7PRD3_SPOS1	CAMK protein kinase. (709 aa)
	U7PS22_SPOS1	HAL protein kinase. (607 aa)
	U7PS47_SPOS1	Uncharacterized protein. (432 aa)
	U7PSJ8_SPOS1	Uncharacterized protein. (981 aa)
	U7PT29_SPOS1	Serine/threonine protein kinase. (808 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	U7PUD0_SPOS1	HAL protein kinase. (1011 aa)
	U7PUF4_SPOS1	CAMK/CAMKL/CHK1 protein kinase. (587 aa)
	U7Q8F0_SPOS1	FHA domain-containing protein. (623 aa)
	U7PV83_SPOS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2111 aa)
	U7PV97_SPOS1	Uncharacterized protein. (923 aa)
	U7PWG5_SPOS1	Ubiquitin-40S ribosomal protein S27a. (154 aa)
	U7PWT7_SPOS1	Uncharacterized protein. (521 aa)
	U7PWY9_SPOS1	Uncharacterized protein. (504 aa)
	U7PXK4_SPOS1	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (632 aa)
	U7PXV6_SPOS1	Uncharacterized protein. (1271 aa)
	U7PY10_SPOS1	DNA_LIGASE_A3 domain-containing protein. (1021 aa)
	U7PYL9_SPOS1	Uncharacterized protein. (585 aa)
	U7PYR3_SPOS1	Uncharacterized protein. (772 aa)
	U7PYT6_SPOS1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (669 aa)
	U7PZ00_SPOS1	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (526 aa)
	U7PZI0_SPOS1	NDT80 domain-containing protein. (667 aa)
	U7PZT2_SPOS1	Uncharacterized protein. (668 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (485 aa)
	U7Q0J8_SPOS1	FHA domain-containing protein. (992 aa)
	U7Q0K1_SPOS1	BZIP domain-containing protein. (411 aa)
	U7Q0V3_SPOS1	Uncharacterized protein. (478 aa)
	U7Q1P2_SPOS1	Uncharacterized protein. (330 aa)
	U7Q1Q9_SPOS1	Polyubiquitin. (305 aa)
	U7Q290_SPOS1	Uncharacterized protein. (912 aa)
	U7Q2D7_SPOS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3901 aa)
	U7Q2G7_SPOS1	3'-5' exonuclease domain-containing protein. (579 aa)
	U7Q2J0_SPOS1	Uncharacterized protein. (715 aa)
	U7Q318_SPOS1	HAL protein kinase; Belongs to the GroES chaperonin family. (879 aa)
	U7Q3M6_SPOS1	Poly [ADP-ribose] polymerase. (705 aa)
	U7Q4G5_SPOS1	zf-GRF domain-containing protein. (644 aa)
	U7Q4H2_SPOS1	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (628 aa)
	U7Q660_SPOS1	Serine/threonine-protein phosphatase. (407 aa)
	U7Q6A5_SPOS1	DUF1767 domain-containing protein. (251 aa)
	U7Q6E5_SPOS1	RECA_2 domain-containing protein. (493 aa)
	U7Q7L9_SPOS1	Uncharacterized protein. (912 aa)
	U7Q7R7_SPOS1	Histone H2B; Belongs to the histone H2B family. (137 aa)

Your Current Organism:

Sporothrix schenckii

NCBI taxonomy Id: 1391915
Other names: S. schenckii ATCC 58251, Sporothrix schenckii ATCC 58251

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	SLX1	U7PTI4	U7PZZ5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.732
FEN1	U7PH72_SPOS1	U7PTI4	U7PH72	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.575
FEN1	U7PHU5_SPOS1	U7PTI4	U7PHU5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ERCC4 domain-containing protein.	0.905
FEN1	U7PJF7_SPOS1	U7PTI4	U7PJF7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Serine/threonine protein kinase.	0.488
FEN1	U7PJH8_SPOS1	U7PTI4	U7PJH8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Asparagine-tRNA ligase.	0.554
FEN1	U7PKR8_SPOS1	U7PTI4	U7PKR8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ERCC4 domain-containing protein.	0.471
FEN1	U7PL29_SPOS1	U7PTI4	U7PL29	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RECA_2 domain-containing protein.	0.894
FEN1	U7PMA4_SPOS1	U7PTI4	U7PMA4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CAMK protein kinase.	0.452
FEN1	U7PMG1_SPOS1	U7PTI4	U7PMG1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.894
FEN1	U7PMR1_SPOS1	U7PTI4	U7PMR1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.879
FEN1	U7PNJ4_SPOS1	U7PTI4	U7PNJ4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.674
FEN1	U7PNX6_SPOS1	U7PTI4	U7PNX6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA_23 domain-containing protein.	0.943
FEN1	U7PPB0_SPOS1	U7PTI4	U7PPB0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.980
FEN1	U7PQL3_SPOS1	U7PTI4	U7PQL3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CAMK protein kinase.	0.452
FEN1	U7PQV4_SPOS1	U7PTI4	U7PQV4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.894
FEN1	U7PRD3_SPOS1	U7PTI4	U7PRD3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CAMK protein kinase.	0.452
FEN1	U7PS22_SPOS1	U7PTI4	U7PS22	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	HAL protein kinase.	0.488
FEN1	U7PSJ8_SPOS1	U7PTI4	U7PSJ8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.625
FEN1	U7PT29_SPOS1	U7PTI4	U7PT29	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Serine/threonine protein kinase.	0.452
FEN1	U7PUD0_SPOS1	U7PTI4	U7PUD0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	HAL protein kinase.	0.488