55 items (Sporothrix schenckii) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	U7PHE8_SPOS1	Uncharacterized protein. (426 aa)
	U7PHS0_SPOS1	CBFD_NFYB_HMF domain-containing protein. (248 aa)
	U7PK33_SPOS1	DNA_pol_E_B domain-containing protein. (960 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (835 aa)
	U7PM20_SPOS1	Replication factor C subunit 4. (359 aa)
	U7PN36_SPOS1	Replication factor C subunit 1. (1117 aa)
	U7PN96_SPOS1	DNA ligase. (874 aa)
	U7PNF7_SPOS1	Uncharacterized protein. (513 aa)
	U7PNQ6_SPOS1	Replication factor C subunit 5. (352 aa)
	U7PNY6_SPOS1	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily. (341 aa)
	U7PPA9_SPOS1	Uncharacterized protein. (215 aa)
	U7PQA3_SPOS1	DNA polymerase. (1545 aa)
	U7PRQ6_SPOS1	RING-type domain-containing protein. (138 aa)
	U7PSF8_SPOS1	DNA helicase; Belongs to the MCM family. (886 aa)
	U7PSN9_SPOS1	AAA domain-containing protein. (414 aa)
	U7PSU2_SPOS1	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (696 aa)
	U7PSZ7_SPOS1	Uncharacterized protein. (1800 aa)
	U7PT11_SPOS1	Uncharacterized protein. (1088 aa)
	U7PTE2_SPOS1	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	U7PTK6_SPOS1	ANAPC5 domain-containing protein. (839 aa)
	U7PTX1_SPOS1	CBFD_NFYB_HMF domain-containing protein. (299 aa)
	U7PU71_SPOS1	BAH domain-containing protein. (774 aa)
	U7PU79_SPOS1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (495 aa)
	U7PUF9_SPOS1	Uncharacterized protein. (143 aa)
	U7PUK1_SPOS1	Uncharacterized protein. (107 aa)
	U7PUL8_SPOS1	AAA_16 domain-containing protein. (764 aa)
	U7PV00_SPOS1	AAA domain-containing protein. (1456 aa)
	U7PW76_SPOS1	DNA polymerase. (1115 aa)
	U7PWG5_SPOS1	Ubiquitin-40S ribosomal protein S27a. (154 aa)
	U7PWN1_SPOS1	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2402 aa)
	U7PX92_SPOS1	Uncharacterized protein. (549 aa)
	U7PYU5_SPOS1	DNA helicase; Belongs to the MCM family. (981 aa)
	U7Q0K1_SPOS1	BZIP domain-containing protein. (411 aa)
	U7Q0V3_SPOS1	Uncharacterized protein. (478 aa)
	U7Q134_SPOS1	DNA ligase. (917 aa)
	U7Q1Q9_SPOS1	Polyubiquitin. (305 aa)
	U7Q2I4_SPOS1	DNA helicase; Belongs to the MCM family. (1070 aa)
	U7Q3Z2_SPOS1	DNA helicase; Belongs to the MCM family. (746 aa)
	U7Q4H2_SPOS1	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (628 aa)
	U7Q4K5_SPOS1	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (468 aa)
	U7Q4L5_SPOS1	Uncharacterized protein. (997 aa)
	U7Q4M9_SPOS1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (785 aa)
	U7Q4P5_SPOS1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (428 aa)
	U7Q4V3_SPOS1	Sld5 domain-containing protein. (240 aa)
	U7Q4V5_SPOS1	Uncharacterized protein. (548 aa)
	U7Q576_SPOS1	AAA domain-containing protein. (412 aa)
	U7Q5E2_SPOS1	Vezatin domain-containing protein. (694 aa)
	U7Q5R3_SPOS1	CMGC/CDK/CDK5 protein kinase. (1257 aa)
	U7Q6L6_SPOS1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (589 aa)
	U7Q723_SPOS1	DNA helicase; Belongs to the MCM family. (934 aa)
	U7Q781_SPOS1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	U7Q874_SPOS1	Zn(2)-C6 fungal-type domain-containing protein. (1076 aa)
	U7Q8H5_SPOS1	Sld5 domain-containing protein. (232 aa)
	U7Q914_SPOS1	Sld5 domain-containing protein. (334 aa)

Your Current Organism:

Sporothrix schenckii

NCBI taxonomy Id: 1391915
Other names: S. schenckii ATCC 58251, Sporothrix schenckii ATCC 58251

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	U7PTI4	U7PLF0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.733
FEN1	U7PHS0_SPOS1	U7PTI4	U7PHS0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CBFD_NFYB_HMF domain-containing protein.	0.770
FEN1	U7PK33_SPOS1	U7PTI4	U7PK33	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_pol_E_B domain-containing protein.	0.844
FEN1	U7PM20_SPOS1	U7PTI4	U7PM20	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 4.	0.916
FEN1	U7PN36_SPOS1	U7PTI4	U7PN36	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 1.	0.897
FEN1	U7PN96_SPOS1	U7PTI4	U7PN96	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.972
FEN1	U7PNQ6_SPOS1	U7PTI4	U7PNQ6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 5.	0.947
FEN1	U7PNY6_SPOS1	U7PTI4	U7PNY6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	CMGC/CDK/CDC2 protein kinase; Belongs to the protein kinase superfamily.	0.494
FEN1	U7PQA3_SPOS1	U7PTI4	U7PQA3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.890
FEN1	U7PRQ6_SPOS1	U7PTI4	U7PRQ6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RING-type domain-containing protein.	0.500
FEN1	U7PSF8_SPOS1	U7PTI4	U7PSF8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.896
FEN1	U7PSN9_SPOS1	U7PTI4	U7PSN9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.939
FEN1	U7PSU2_SPOS1	U7PTI4	U7PSU2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.822
FEN1	U7PSZ7_SPOS1	U7PTI4	U7PSZ7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.972
FEN1	U7PU71_SPOS1	U7PTI4	U7PU71	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	BAH domain-containing protein.	0.545
FEN1	U7PUL8_SPOS1	U7PTI4	U7PUL8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA_16 domain-containing protein.	0.691
FEN1	U7PV00_SPOS1	U7PTI4	U7PV00	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	AAA domain-containing protein.	0.897
FEN1	U7PW76_SPOS1	U7PTI4	U7PW76	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.991
FEN1	U7PWN1_SPOS1	U7PTI4	U7PWN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.912
FEN1	U7PYU5_SPOS1	U7PTI4	U7PYU5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.784