(41 nodes) Mixed, incl. Synthesis of very long-chain fatty acyl-CoAs, and Fatty acid desaturase network (Aspergillus novofumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2I1BSL8	Uncharacterized protein. (195 aa)
	A0A2I1BSR5	Uncharacterized protein. (291 aa)
	A0A2I1BT24	Uncharacterized protein. (177 aa)
	A0A2I1BTI1	Putative methyltransferase. (286 aa)
	A0A2I1BTJ5	Beta-xylanase. (359 aa)
	A0A2I1BTZ7	Uncharacterized protein. (55 aa)
	A0A2I1BTZ9	Uncharacterized protein. (102 aa)
	A0A2I1BX97	Putative fatty acid desaturase. (548 aa)
	A0A2I1BXK7	Uncharacterized protein. (295 aa)
	A0A2I1BXL8	Oxidoreductase. (243 aa)
	A0A2I1BYJ2	C6 zinc finger domain protein. (197 aa)
	A0A2I1BZ65	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (431 aa)
	A0A2I1BZA8	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (460 aa)
	A0A2I1C009	PWWP domain-containing protein. (595 aa)
	A0A2I1C182	MFS general substrate transporter. (441 aa)
	A0A2I1C1E7	Putative NADP(+)-dependent dehydrogenase. (242 aa)
	A0A2I1C1L3	BZIP domain-containing protein. (218 aa)
	A0A2I1C2Y3	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (201 aa)
	A0A2I1C4U9	Putative MFS transporter. (574 aa)
	A0A2I1C4Z6	Steroid alpha reductase family protein. (311 aa)
	A0A2I1C570	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (234 aa)
	A0A2I1C7Q1	Elongation of fatty acids protein. (547 aa)
	A0A2I1C7X2	Putative short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
	A0A2I1C901	FA_desaturase domain-containing protein. (351 aa)
	A0A2I1CB23	MFS transporter. (458 aa)
	A0A2I1CBI2	Putative MFS multidrug transporter. (558 aa)
	A0A2I1CCK0	Putative bZIP transcription factor. (608 aa)
	A0A2I1CEH7	Oleate delta-12 desaturase. (388 aa)
	A0A2I1CFQ3	Putative MFS transporter. (585 aa)
	A0A2I1CG05	Elongation of fatty acids protein. (344 aa)
	A0A2I1CGP6	Uncharacterized protein. (870 aa)
	A0A2I1CJB8	Oxidoreductase. (243 aa)
	A0A2I1CJG5	Beta-xylanase. (345 aa)
	A0A2I1CKG9	Putative fatty acid desaturase. (565 aa)
	A0A2I1CKM1	Putative bZIP transcription factor. (323 aa)
	A0A2I1CKW4	F-box domain protein. (970 aa)
	A0A2I1CMV6	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (345 aa)
	A0A2I1CMX3	Putative MFS transporter. (354 aa)
	A0A2I1CN55	Putative MFS transporter. (468 aa)
	A0A2I1CPC2	Putative MFS transporter. (491 aa)
	A0A2I1CPW4	Putative MFS transporter. (496 aa)

Your Current Organism:

Aspergillus novofumigatus

NCBI taxonomy Id: 1392255
Other names: A. novofumigatus IBT 16806, Aspergillus novofumigatus IBT 16806

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2I1BSL8	A0A2I1BT24	Uncharacterized protein.	Uncharacterized protein.	0.580
A0A2I1BSL8	A0A2I1BX97	Uncharacterized protein.	Putative fatty acid desaturase.	0.479
A0A2I1BSL8	A0A2I1BZ65	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.754
A0A2I1BSL8	A0A2I1BZA8	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.754
A0A2I1BSL8	A0A2I1C009	Uncharacterized protein.	PWWP domain-containing protein.	0.580
A0A2I1BSL8	A0A2I1C1L3	Uncharacterized protein.	BZIP domain-containing protein.	0.668
A0A2I1BSL8	A0A2I1C2Y3	Uncharacterized protein.	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	0.668
A0A2I1BSL8	A0A2I1C4Z6	Uncharacterized protein.	Steroid alpha reductase family protein.	0.821
A0A2I1BSL8	A0A2I1C570	Uncharacterized protein.	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]	0.668
A0A2I1BSL8	A0A2I1C7Q1	Uncharacterized protein.	Elongation of fatty acids protein.	0.418
A0A2I1BSL8	A0A2I1CCK0	Uncharacterized protein.	Putative bZIP transcription factor.	0.668
A0A2I1BSL8	A0A2I1CG05	Uncharacterized protein.	Elongation of fatty acids protein.	0.418
A0A2I1BSL8	A0A2I1CGP6	Uncharacterized protein.	Uncharacterized protein.	0.418
A0A2I1BSL8	A0A2I1CKG9	Uncharacterized protein.	Putative fatty acid desaturase.	0.479
A0A2I1BSL8	A0A2I1CKM1	Uncharacterized protein.	Putative bZIP transcription factor.	0.668
A0A2I1BSL8	A0A2I1CKW4	Uncharacterized protein.	F-box domain protein.	0.418
A0A2I1BSR5	A0A2I1BZ65	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BSR5	A0A2I1BZA8	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BT24	A0A2I1BSL8	Uncharacterized protein.	Uncharacterized protein.	0.580
A0A2I1BT24	A0A2I1BTZ7	Uncharacterized protein.	Uncharacterized protein.	0.580