(57 nodes) RNA polymerase II, holoenzyme network (Aspergillus novofumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2I1BS95	Helicase C-terminal domain-containing protein. (213 aa)
	A0A2I1BS82	Uncharacterized protein. (403 aa)
	A0A2I1BSK8	Uncharacterized protein. (309 aa)
	A0A2I1BTP4	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5. (66 aa)
	A0A2I1BTR2	Bromodomain associated protein. (385 aa)
	A0A2I1BU12	Helicase ATP-binding domain-containing protein. (432 aa)
	A0A2I1BWB0	Putative transcription initiation factor TFIID subunit. (749 aa)
	A0A2I1BY15	Uncharacterized protein. (110 aa)
	A0A2I1BY77	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1255 aa)
	A0A2I1BZQ9	Putative serine/threonine protein kinase; Belongs to the protein kinase superfamily. (404 aa)
	A0A2I1BZU0	RBP11-like subunits of RNA polymerase. (129 aa)
	A0A2I1C062	Uncharacterized protein. (1277 aa)
	A0A2I1C079	RNA polymerase II subunit 7. (169 aa)
	A0A2I1C0A0	Transcription initiation factor iif, beta subunit. (374 aa)
	A0A2I1C0L0	Uncharacterized protein. (419 aa)
	A0A2I1C1R5	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (669 aa)
	A0A2I1C1W4	TFIID_20kDa domain-containing protein. (590 aa)
	A0A2I1C3M7	Uncharacterized protein. (592 aa)
	A0A2I1C4K5	Putative PHD finger domain protein. (821 aa)
	A0A2I1C4N3	Metallothionein-I gene transcription activator. (75 aa)
	A0A2I1C4T6	Putative RNA polymerase II transcription factor-related protein. (601 aa)
	A0A2I1C569	DUF618-domain-containing protein. (416 aa)
	A0A2I1C5L5	CDK-activating kinase assembly factor MAT1. (379 aa)
	A0A2I1C629	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (540 aa)
	A0A2I1C6S1	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
	A0A2I1C867	Putative transcription factor TFIIA complex subunit Toa1. (410 aa)
	A0A2I1C8C1	TFIID-31kDa-domain-containing protein. (307 aa)
	A0A2I1C8F1	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1718 aa)
	A0A2I1C8H4	Putative TFIIH complex helicase Rad3. (794 aa)
	A0A2I1C8K3	RNA polymerase subunit. (234 aa)
	A0A2I1C972	DUF4211 domain-containing protein. (588 aa)
	A0A2I1C9Y0	TFIID-18kDa-domain-containing protein. (170 aa)
	A0A2I1C9Y8	Uncharacterized protein. (470 aa)
	A0A2I1CA37	WD domain protein. (302 aa)
	A0A2I1CAW4	DNA-directed RNA polymerase I, II, and III subunit Rpb6. (161 aa)
	A0A2I1CBJ6	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (290 aa)
	A0A2I1CD23	Putative transcription factor TFIID complex 145 kDa subunit. (1111 aa)
	A0A2I1CFA2	Helicase ATP-binding domain-containing protein. (120 aa)
	A0A2I1CG91	Putative TFIIH complex helicase Ssl2. (829 aa)
	A0A2I1CGA0	TAFII28 domain-containing protein. (402 aa)
	A0A2I1CGD3	Transcription initiation factor TFIID complex 60 kDa subunit. (421 aa)
	A0A2I1CGG7	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (446 aa)
	A0A2I1CGQ8	Putative RNA polymerase II transcription elongation factor. (1190 aa)
	A0A2I1CH80	Putative cyclin Ccl1; Belongs to the cyclin family. (432 aa)
	A0A2I1CID6	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
	A0A2I1CIH8	Uncharacterized protein. (261 aa)
	A0A2I1CII8	Putative transcription factor TFIIH subunit Tfb4. (385 aa)
	A0A2I1CKD9	Putative RNA polymerase II transcription elongation factor Rtf1p. (607 aa)
	A0A2I1CM22	Putative transcription factor TFIIE complex alpha subunit. (440 aa)
	A0A2I1CM31	Putative DNA directed RNA polymerase II 15 kDa subunit. (122 aa)
	A0A2I1CMS8	Putative Pol II transcription elongation factor subunit Cdc73. (474 aa)
	A0A2I1CMT0	Uncharacterized protein. (551 aa)
	A0A2I1CNA7	RNA polymerase II subunit 3. (336 aa)
	A0A2I1CNV4	TAFII55_N domain-containing protein. (486 aa)
	A0A2I1CNX7	Bromodomain associated protein. (217 aa)
	A0A2I1CP38	Uncharacterized protein. (375 aa)
	A0A2I1CP42	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)

Your Current Organism:

Aspergillus novofumigatus

NCBI taxonomy Id: 1392255
Other names: A. novofumigatus IBT 16806, Aspergillus novofumigatus IBT 16806

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2I1BS82	A0A2I1C079	Uncharacterized protein.	RNA polymerase II subunit 7.	0.450
A0A2I1BS82	A0A2I1C569	Uncharacterized protein.	DUF618-domain-containing protein.	0.416
A0A2I1BS82	A0A2I1C8H4	Uncharacterized protein.	Putative TFIIH complex helicase Rad3.	0.443
A0A2I1BS82	A0A2I1C8K3	Uncharacterized protein.	RNA polymerase subunit.	0.414
A0A2I1BS95	A0A2I1C079	Helicase C-terminal domain-containing protein.	RNA polymerase II subunit 7.	0.450
A0A2I1BS95	A0A2I1C569	Helicase C-terminal domain-containing protein.	DUF618-domain-containing protein.	0.416
A0A2I1BS95	A0A2I1C8H4	Helicase C-terminal domain-containing protein.	Putative TFIIH complex helicase Rad3.	0.443
A0A2I1BS95	A0A2I1C8K3	Helicase C-terminal domain-containing protein.	RNA polymerase subunit.	0.414
A0A2I1BSK8	A0A2I1C079	Uncharacterized protein.	RNA polymerase II subunit 7.	0.450
A0A2I1BSK8	A0A2I1C569	Uncharacterized protein.	DUF618-domain-containing protein.	0.416
A0A2I1BSK8	A0A2I1C8H4	Uncharacterized protein.	Putative TFIIH complex helicase Rad3.	0.443
A0A2I1BSK8	A0A2I1C8K3	Uncharacterized protein.	RNA polymerase subunit.	0.414
A0A2I1BTP4	A0A2I1BY15	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	Uncharacterized protein.	0.872
A0A2I1BTP4	A0A2I1BY77	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.864
A0A2I1BTP4	A0A2I1BZQ9	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	Putative serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.836
A0A2I1BTP4	A0A2I1BZU0	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	RBP11-like subunits of RNA polymerase.	0.864
A0A2I1BTP4	A0A2I1C079	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	RNA polymerase II subunit 7.	0.856
A0A2I1BTP4	A0A2I1C0A0	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	Transcription initiation factor iif, beta subunit.	0.864
A0A2I1BTP4	A0A2I1C0L0	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	Uncharacterized protein.	0.935
A0A2I1BTP4	A0A2I1C1R5	RNA polymerase II general transcription and DNA repair factor TFIIH component Tfb5.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.864