(107 nodes) Biosynthesis of unsaturated fatty acids network (Aspergillus novofumigatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A2I1CFP2	Putative MFS multidrug transporter. (574 aa)
	A0A2I1BX72	Uncharacterized protein. (161 aa)
	A0A2I1BX97	Putative fatty acid desaturase. (548 aa)
	A0A2I1BXJ5	MFS general substrate transporter. (512 aa)
	A0A2I1BXK7	Uncharacterized protein. (295 aa)
	A0A2I1BXL3	Hemerythrin HHE cation binding domain protein. (227 aa)
	A0A2I1BXN6	Putative acyl-CoA oxidase. (739 aa)
	A0A2I1BYJ2	C6 zinc finger domain protein. (197 aa)
	A0A2I1BYQ0	Putative MFS transporter. (488 aa)
	A0A2I1BZ10	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (692 aa)
	A0A2I1BZ65	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (431 aa)
	A0A2I1BZA8	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (460 aa)
	A0A2I1BZF6	BEM46 family protein. (296 aa)
	A0A2I1BZH5	Putative MFS transporter. (505 aa)
	A0A2I1BZP6	Putative 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	A0A2I1C0K4	Putative acetyl xylan esterase. (358 aa)
	A0A2I1C0Q6	Putative MFS transporter. (549 aa)
	A0A2I1CPW4	Putative MFS transporter. (496 aa)
	A0A2I1CPM5	Putative MFS multidrug transporter. (546 aa)
	A0A2I1CPC2	Putative MFS transporter. (491 aa)
	A0A2I1CNS3	Uncharacterized protein. (244 aa)
	A0A2I1CNR4	HHE domain protein. (191 aa)
	A0A2I1CNG7	Putative MFS transporter. (546 aa)
	A0A2I1CN73	Putative MFS multidrug transporter. (522 aa)
	A0A2I1CN55	Putative MFS transporter. (468 aa)
	A0A2I1CMX3	Putative MFS transporter. (354 aa)
	A0A2I1CMW6	Putative MFS multidrug transporter. (607 aa)
	A0A2I1CMV6	Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. (345 aa)
	A0A2I1CMV1	Putative peroxisomal 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	A0A2I1CMB3	Uncharacterized protein. (280 aa)
	A0A2I1CLM2	MFS general substrate transporter. (412 aa)
	A0A2I1CLL9	Transcription activator of gluconeogenesis acuK. (682 aa)
	A0A2I1CKW4	F-box domain protein. (970 aa)
	A0A2I1CKM1	Putative bZIP transcription factor. (323 aa)
	A0A2I1CKG9	Putative fatty acid desaturase. (565 aa)
	A0A2I1CK61	Uncharacterized protein. (64 aa)
	A0A2I1CJG5	Beta-xylanase. (345 aa)
	A0A2I1CJB9	Putative MFS transporter. (483 aa)
	A0A2I1CIV9	Synaptic vesicle transporter. (596 aa)
	A0A2I1CI15	Putative MFS multidrug transporter. (558 aa)
	A0A2I1CGW7	Putative MFS transporter. (612 aa)
	A0A2I1CGP6	Uncharacterized protein. (870 aa)
	A0A2I1CG30	Putative MFS multidrug transporter. (538 aa)
	A0A2I1CG05	Elongation of fatty acids protein. (344 aa)
	A0A2I1BX63	Alpha/beta-hydrolase. (292 aa)
	A0A2I1CFN0	Putative MFS multidrug transporter. (551 aa)
	A0A2I1CFE1	Putative MFS transporter. (789 aa)
	A0A2I1CEH7	Oleate delta-12 desaturase. (388 aa)
	A0A2I1CEH1	Putative C6 transcription factor. (604 aa)
	A0A2I1CEE2	Uncharacterized protein. (61 aa)
	A0A2I1CED9	MFS general substrate transporter. (507 aa)
	A0A2I1CDL0	Putative geranylgeranyl transferase beta subunit. (416 aa)
	A0A2I1CCK0	Putative bZIP transcription factor. (608 aa)
	A0A2I1CC32	MFS general substrate transporter. (422 aa)
	A0A2I1CBM6	Putative lipid transfer protein. (155 aa)
	A0A2I1CBI2	Putative MFS multidrug transporter. (558 aa)
	A0A2I1CBE2	Beta-xylanase. (397 aa)
	A0A2I1CB36	Uncharacterized protein. (414 aa)
	A0A2I1CB23	MFS transporter. (458 aa)
	A0A2I1CA18	IQ calmodulin-binding motif domain protein. (986 aa)
	A0A2I1C9P8	Putative MFS multidrug transporter. (557 aa)
	A0A2I1C974	Uncharacterized protein. (462 aa)
	A0A2I1C901	FA_desaturase domain-containing protein. (351 aa)
	A0A2I1C8Y8	Putative 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	A0A2I1C8Q9	Putative mfs-family multidrug resistance protein. (665 aa)
	A0A2I1C7X2	Putative short chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
	A0A2I1BSR5	Uncharacterized protein. (291 aa)
	A0A2I1BT36	HHE domain protein. (221 aa)
	A0A2I1BT98	Uncharacterized protein. (322 aa)
	A0A2I1BTE2	Uncharacterized protein. (327 aa)
	A0A2I1BTI1	Putative methyltransferase. (286 aa)
	A0A2I1BTJ5	Beta-xylanase. (359 aa)
	A0A2I1BU40	MFS general substrate transporter. (534 aa)
	A0A2I1BU97	Putative MFS transporter. (498 aa)
	A0A2I1BUC4	HHE domain protein. (223 aa)
	A0A2I1BUD1	Putative MFS multidrug transporter. (445 aa)
	A0A2I1BUH2	Putative MFS multidrug transporter. (546 aa)
	A0A2I1BV13	MFS general substrate transporter. (517 aa)
	A0A2I1BV84	Putative MFS multidrug transporter. (499 aa)
	A0A2I1BVC8	Putative MFS multidrug transporter. (510 aa)
	A0A2I1BVK5	Putative MFS transporter. (506 aa)
	A0A2I1BVL9	Putative alpha/beta superfamily hydrolase. (408 aa)
	A0A2I1BVU6	Putative MFS multidrug transporter. (538 aa)
	A0A2I1BWM9	Putative MFS multidrug transporter. (515 aa)
	A0A2I1C7Q5	Short chain dehydrogenase family protein. (313 aa)
	A0A2I1C7Q1	Elongation of fatty acids protein. (547 aa)
	A0A2I1C6E9	Putative MFS transporter. (582 aa)
	A0A2I1C6B5	Putative sterol carrier protein; Belongs to the thiolase-like superfamily. Thiolase family. (458 aa)
	A0A2I1C628	Putative camp-mediated signaling protein Sok1. (594 aa)
	A0A2I1C623	Putative acyl-CoA thioester hydrolase. (409 aa)
	A0A2I1C5Q7	Alpha/beta-hydrolase. (416 aa)
	A0A2I1C590	Beta-xylanase. (314 aa)
	A0A2I1C570	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (234 aa)
	A0A2I1C4Z6	Steroid alpha reductase family protein. (311 aa)
	A0A2I1C4Y0	3-ketoacyl-CoA thiolase peroxisomal A; Belongs to the thiolase-like superfamily. Thiolase family. (419 aa)
	A0A2I1C4P9	Putative MFS transporter. (426 aa)
	A0A2I1C4L4	Putative C6 transcription factor Prf. (840 aa)
	A0A2I1C2Y3	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (201 aa)
	A0A2I1C1L3	BZIP domain-containing protein. (218 aa)
	A0A2I1C1E7	Putative NADP(+)-dependent dehydrogenase. (242 aa)
	A0A2I1C1D3	Uncharacterized protein. (292 aa)
	A0A2I1C182	MFS general substrate transporter. (441 aa)
	A0A2I1C171	Putative MFS multidrug transporter. (421 aa)
	A0A2I1C0V8	Putative integral membrane protein. (164 aa)
	A0A2I1BWS6	Putative MFS transporter. (465 aa)
	A0A2I1BWT6	Uncharacterized protein. (546 aa)
	A0A2I1BX33	Uncharacterized protein. (523 aa)

Your Current Organism:

Aspergillus novofumigatus

NCBI taxonomy Id: 1392255
Other names: A. novofumigatus IBT 16806, Aspergillus novofumigatus IBT 16806

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2I1BSR5	A0A2I1BZ65	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BSR5	A0A2I1BZA8	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BT36	A0A2I1BZ65	HHE domain protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BT36	A0A2I1BZA8	HHE domain protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BT98	A0A2I1BZ65	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BT98	A0A2I1BZA8	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BTE2	A0A2I1BZ65	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BTE2	A0A2I1BZA8	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BTI1	A0A2I1BZ65	Putative methyltransferase.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BTI1	A0A2I1BZA8	Putative methyltransferase.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BTJ5	A0A2I1BZ65	Beta-xylanase.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BTJ5	A0A2I1BZA8	Beta-xylanase.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BU40	A0A2I1BZ65	MFS general substrate transporter.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BU40	A0A2I1BZA8	MFS general substrate transporter.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BU97	A0A2I1BZ65	Putative MFS transporter.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BU97	A0A2I1BZA8	Putative MFS transporter.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BUC4	A0A2I1BZ65	HHE domain protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BUC4	A0A2I1BZA8	HHE domain protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BUD1	A0A2I1BZ65	Putative MFS multidrug transporter.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545
A0A2I1BUD1	A0A2I1BZA8	Putative MFS multidrug transporter.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.545