(75 nodes) 2-Oxocarboxylic acid metabolism network (Aspergillus novofumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A2I1BTA7	GFA domain-containing protein. (189 aa)
	A0A2I1BTB0	Dihydroxy-acid dehydratase. (619 aa)
	A0A2I1BTD8	Isocitrate dehydrogenase family protein. (559 aa)
	A0A2I1BTJ9	Ketol-acid reductoisomerase; Belongs to the ketol-acid reductoisomerase family. (495 aa)
	A0A2I1BTU5	Zn(2)-C6 fungal-type domain-containing protein. (616 aa)
	A0A2I1BVK1	Putative MFS transporter. (416 aa)
	A0A2I1BVZ0	Putative aspartate aminotransferase. (444 aa)
	A0A2I1BW02	Putative tartrate dehydrogenase. (363 aa)
	A0A2I1BW40	Putative mitochondrial dihydroxy acid dehydratase. (608 aa)
	A0A2I1BWH0	DUF636 domain protein. (147 aa)
	A0A2I1BWQ2	Branched-chain amino acid aminotransferase. (364 aa)
	A0A2I1BWX8	PLP-dependent transferase. (162 aa)
	A0A2I1BXF1	Tartrate dehydrogenase. (542 aa)
	A0A2I1BZ24	Uncharacterized protein. (190 aa)
	A0A2I1BZN3	Uncharacterized protein. (544 aa)
	A0A2I1C0U4	Aconitase family protein. (799 aa)
	A0A2I1C0V4	Isocitrate/isopropylmalate dehydrogenase. (351 aa)
	A0A2I1C1T9	Uncharacterized protein. (345 aa)
	A0A2I1C227	Aspartate-semialdehyde dehydrogenase. (363 aa)
	A0A2I1C268	Putative vacuolar carboxypeptidase Cps1. (552 aa)
	A0A2I1C2R0	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (486 aa)
	A0A2I1C355	Acetolactate synthase. (694 aa)
	A0A2I1C3H8	Putative MFS transporter. (529 aa)
	A0A2I1C3N3	C6 zinc finger domain protein. (659 aa)
	A0A2I1C473	Putative MFS multidrug resistance transporter. (556 aa)
	A0A2I1C4U9	Putative MFS transporter. (574 aa)
	A0A2I1C539	Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (463 aa)
	A0A2I1C546	Putative aspartate aminotransferase. (437 aa)
	A0A2I1C633	Putative mitochondrial acetolactate synthase small subunit. (327 aa)
	A0A2I1C6I5	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (414 aa)
	A0A2I1C843	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (366 aa)
	A0A2I1C869	2-isopropylmalate synthase. (626 aa)
	A0A2I1C8W9	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
	A0A2I1CAB9	Putative dihydroxy-acid dehydratase. (606 aa)
	A0A2I1CAE0	Aconitate hydratase. (1252 aa)
	A0A2I1CBD7	3-isopropylmalate dehydrogenase. (359 aa)
	A0A2I1CBP2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (770 aa)
	A0A2I1CBT9	Uncharacterized protein. (639 aa)
	A0A2I1CCH4	Aspartate aminotransferase. (423 aa)
	A0A2I1CCK1	C6 zinc finger domain protein. (619 aa)
	A0A2I1CDA7	Putative alanine aminotransferase. (495 aa)
	A0A2I1CDD7	Isocitrate dehydrogenase LysB. (346 aa)
	A0A2I1CDJ9	Putative carboxypeptidase. (422 aa)
	A0A2I1CDQ3	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
	A0A2I1CE98	Citrate synthase; Belongs to the citrate synthase family. (465 aa)
	A0A2I1CEC9	MFS general substrate transporter. (292 aa)
	A0A2I1CEK5	Putative acetylglutamate kinase; In the N-terminal section; belongs to the acetylglutamate kinase family. (906 aa)
	A0A2I1CEN3	Aspartate aminotransferase. (412 aa)
	A0A2I1CFD0	Acetolactate synthase. (631 aa)
	A0A2I1CFD6	Putative aminotransferase, class IV. (323 aa)
	A0A2I1CFQ3	Putative MFS transporter. (585 aa)
	A0A2I1CG61	Putative aromatic amino acid aminotransferase. (594 aa)
	A0A2I1CGF3	Citrate synthase; Belongs to the citrate synthase family. (429 aa)
	A0A2I1CGH3	Uncharacterized protein. (58 aa)
	A0A2I1CGK6	Aspartokinase. (521 aa)
	A0A2I1CH45	Putative MFS transporter. (428 aa)
	A0A2I1CHK3	Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate; Belongs to the ArgJ family. (423 aa)
	A0A2I1CHP4	Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (706 aa)
	A0A2I1CI32	Putative peptidase. (344 aa)
	A0A2I1CJG8	Carboxypeptidase S. (539 aa)
	A0A2I1CJS7	Citrate synthase; Belongs to the citrate synthase family. (474 aa)
	A0A2I1CJU8	Acetylornithine deacetylase. (753 aa)
	A0A2I1CKT7	Uncharacterized protein. (205 aa)
	A0A2I1CLG8	Putative MFS transporter. (437 aa)
	A0A2I1CM07	Ubiquitin-like domain-containing protein. (86 aa)
	A0A2I1CME4	Putative aspartate transaminase. (441 aa)
	A0A2I1CMK5	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (397 aa)
	A0A2I1CMS2	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (769 aa)
	A0A2I1CMU6	Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family. (702 aa)
	A0A2I1CNJ5	Putative aromatic aminotransferase Aro8. (526 aa)
	A0A2I1CNM4	Putative dihydroxy acid dehydratase Ilv3. (560 aa)
	A0A2I1CNQ4	GFA domain-containing protein. (179 aa)
	A0A2I1CP03	Citrate synthase; Belongs to the citrate synthase family. (440 aa)
	A0A2I1CP09	Putative MFS efflux transporter. (498 aa)
	A0A2I1CPB3	Putative dihydroxy acid dehydratase. (654 aa)

Your Current Organism:

Aspergillus novofumigatus

NCBI taxonomy Id: 1392255
Other names: A. novofumigatus IBT 16806, Aspergillus novofumigatus IBT 16806

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2I1BTA7	A0A2I1BTB0	GFA domain-containing protein.	Dihydroxy-acid dehydratase.	0.440
A0A2I1BTA7	A0A2I1BW40	GFA domain-containing protein.	Putative mitochondrial dihydroxy acid dehydratase.	0.440
A0A2I1BTA7	A0A2I1BZN3	GFA domain-containing protein.	Uncharacterized protein.	0.723
A0A2I1BTA7	A0A2I1C0U4	GFA domain-containing protein.	Aconitase family protein.	0.809
A0A2I1BTA7	A0A2I1C1T9	GFA domain-containing protein.	Uncharacterized protein.	0.602
A0A2I1BTA7	A0A2I1C227	GFA domain-containing protein.	Aspartate-semialdehyde dehydrogenase.	0.448
A0A2I1BTA7	A0A2I1C2R0	GFA domain-containing protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.602
A0A2I1BTA7	A0A2I1C355	GFA domain-containing protein.	Acetolactate synthase.	0.600
A0A2I1BTA7	A0A2I1C539	GFA domain-containing protein.	Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.723
A0A2I1BTA7	A0A2I1C546	GFA domain-containing protein.	Putative aspartate aminotransferase.	0.562
A0A2I1BTA7	A0A2I1C633	GFA domain-containing protein.	Putative mitochondrial acetolactate synthase small subunit.	0.836
A0A2I1BTA7	A0A2I1C869	GFA domain-containing protein.	2-isopropylmalate synthase.	0.723
A0A2I1BTA7	A0A2I1CAB9	GFA domain-containing protein.	Putative dihydroxy-acid dehydratase.	0.440
A0A2I1BTA7	A0A2I1CAE0	GFA domain-containing protein.	Aconitate hydratase.	0.770
A0A2I1BTA7	A0A2I1CBP2	GFA domain-containing protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.770
A0A2I1BTA7	A0A2I1CBT9	GFA domain-containing protein.	Uncharacterized protein.	0.723
A0A2I1BTA7	A0A2I1CDA7	GFA domain-containing protein.	Putative alanine aminotransferase.	0.492
A0A2I1BTA7	A0A2I1CDQ3	GFA domain-containing protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.947
A0A2I1BTA7	A0A2I1CE98	GFA domain-containing protein.	Citrate synthase; Belongs to the citrate synthase family.	0.698
A0A2I1BTA7	A0A2I1CEK5	GFA domain-containing protein.	Putative acetylglutamate kinase; In the N-terminal section; belongs to the acetylglutamate kinase family.	0.464