(18 nodes) Sulfur relay system network (Aspergillus novofumigatus)

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	A0A2I1BTN9	Putative tRNA splicing protein. (517 aa)
	A0A2I1BV08	PK beta-barrel-protein domain-containing protein-like protein. (200 aa)
	A0A2I1BVY6	PK beta-barrel-protein domain-containing protein-like protein. (166 aa)
	A0A2I1BW87	Rhodanese domain protein. (214 aa)
	A0A2I1BXM3	Rhodanese domain-containing protein. (207 aa)
	A0A2I1BYE2	Putative thiosulfate sulfurtransferase. (338 aa)
	A0A2I1C2A7	Molybdopterin biosynthesis MoaE. (99 aa)
	A0A2I1C2C9	Putative polysaccharide deacetylase. (447 aa)
	A0A2I1C677	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (205 aa)
	A0A2I1C7T7	Molybdopterin cofactor. (694 aa)
	NCS6	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (409 aa)
	URM1	Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (114 aa)
	A0A2I1CER9	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (168 aa)
	A0A2I1CFD8	Uncharacterized protein. (750 aa)
	A0A2I1CFK4	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (166 aa)
	A0A2I1CHP7	Putative ThiF domain protein. (513 aa)
	uba4	Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (494 aa)
	NCS2	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (370 aa)

Your Current Organism:

Aspergillus novofumigatus

NCBI taxonomy Id: 1392255
Other names: A. novofumigatus IBT 16806, Aspergillus novofumigatus IBT 16806

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A2I1BTN9	A0A2I1BW87	A0A2I1BTN9	A0A2I1BW87	Putative tRNA splicing protein.	Rhodanese domain protein.	0.850
A0A2I1BTN9	A0A2I1BXM3	A0A2I1BTN9	A0A2I1BXM3	Putative tRNA splicing protein.	Rhodanese domain-containing protein.	0.933
A0A2I1BTN9	A0A2I1BYE2	A0A2I1BTN9	A0A2I1BYE2	Putative tRNA splicing protein.	Putative thiosulfate sulfurtransferase.	0.948
A0A2I1BTN9	A0A2I1C677	A0A2I1BTN9	A0A2I1C677	Putative tRNA splicing protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.999
A0A2I1BTN9	A0A2I1CFD8	A0A2I1BTN9	A0A2I1CFD8	Putative tRNA splicing protein.	Uncharacterized protein.	0.753
A0A2I1BTN9	A0A2I1CHP7	A0A2I1BTN9	A0A2I1CHP7	Putative tRNA splicing protein.	Putative ThiF domain protein.	0.760
A0A2I1BTN9	NCS2	A0A2I1BTN9	A0A2I1CIV6	Putative tRNA splicing protein.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.416
A0A2I1BTN9	NCS6	A0A2I1BTN9	A0A2I1CB43	Putative tRNA splicing protein.	Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.551
A0A2I1BTN9	uba4	A0A2I1BTN9	A0A2I1CI73	Putative tRNA splicing protein.	Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.960
A0A2I1BV08	A0A2I1C2A7	A0A2I1BV08	A0A2I1C2A7	PK beta-barrel-protein domain-containing protein-like protein.	Molybdopterin biosynthesis MoaE.	0.672
A0A2I1BV08	A0A2I1C2C9	A0A2I1BV08	A0A2I1C2C9	PK beta-barrel-protein domain-containing protein-like protein.	Putative polysaccharide deacetylase.	0.672
A0A2I1BV08	A0A2I1C7T7	A0A2I1BV08	A0A2I1C7T7	PK beta-barrel-protein domain-containing protein-like protein.	Molybdopterin cofactor.	0.852
A0A2I1BVY6	A0A2I1C2A7	A0A2I1BVY6	A0A2I1C2A7	PK beta-barrel-protein domain-containing protein-like protein.	Molybdopterin biosynthesis MoaE.	0.672
A0A2I1BVY6	A0A2I1C2C9	A0A2I1BVY6	A0A2I1C2C9	PK beta-barrel-protein domain-containing protein-like protein.	Putative polysaccharide deacetylase.	0.672
A0A2I1BVY6	A0A2I1C7T7	A0A2I1BVY6	A0A2I1C7T7	PK beta-barrel-protein domain-containing protein-like protein.	Molybdopterin cofactor.	0.852
A0A2I1BW87	A0A2I1BTN9	A0A2I1BW87	A0A2I1BTN9	Rhodanese domain protein.	Putative tRNA splicing protein.	0.850
A0A2I1BW87	A0A2I1BXM3	A0A2I1BW87	A0A2I1BXM3	Rhodanese domain protein.	Rhodanese domain-containing protein.	0.771
A0A2I1BW87	A0A2I1BYE2	A0A2I1BW87	A0A2I1BYE2	Rhodanese domain protein.	Putative thiosulfate sulfurtransferase.	0.773
A0A2I1BW87	A0A2I1C2A7	A0A2I1BW87	A0A2I1C2A7	Rhodanese domain protein.	Molybdopterin biosynthesis MoaE.	0.854
A0A2I1BW87	A0A2I1C2C9	A0A2I1BW87	A0A2I1C2C9	Rhodanese domain protein.	Putative polysaccharide deacetylase.	0.854