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| | dnaX | DNA polymerase III subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (523 aa) |
| | KIR01187.1 | RNA polymerase sigma-54 factor RpoN; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | KIR01206.1 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (436 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa) |
| | KIR01233.1 | Hypothetical protein. (306 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (522 aa) |
| | KIR01264.1 | Hypothetical protein; FIG00527456:. (467 aa) |
| | KIR01284.1 | Hypothetical protein. (130 aa) |
| | KIR01341.1 | Ribosomal-protein-alanine acetyltransferase. (143 aa) |
| | KIR01342.1 | Hypothetical protein. (204 aa) |
| | KIR01343.1 | Tryptophan synthase beta chain. (387 aa) |
| | KIR01357.1 | Thiazole biosynthesis protein ThiH. (471 aa) |
| | KIR01358.1 | Biotin synthase. (343 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (321 aa) |
| | KIR01374.1 | Putative peptidoglycan bound protein (LPXTG motif). (901 aa) |
| | polC | DNA polymerase III alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1472 aa) |
| | KIR01386.1 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (217 aa) |
| | KIR01396.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (273 aa) |
| | KIR01397.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (55 aa) |
| | KIR01401.1 | RNA polymerase sigma-54 factor RpoN; Belongs to the sigma-70 factor family. ECF subfamily. (186 aa) |
| | KIR01405.1 | Hydrolase (HAD superfamily), YqeK. (159 aa) |
| | nadD | Hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (204 aa) |
| | KIR01415.1 | GTP pyrophosphokinase. (199 aa) |
| | KIR01465.1 | Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family. (359 aa) |
| | pyrD | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (302 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (255 aa) |
| | KIR01471.1 | Putative coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (361 aa) |
| | KIR01478.1 | Hypothetical protein. (324 aa) |
| | KIR01479.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (484 aa) |
| | KIR01512.1 | Riboflavin kinase / FMN adenylyltransferase. (226 aa) |
| | KIR01513.1 | Riboflavin kinase / FMN adenylyltransferase. (84 aa) |
| | nusA | Transcription termination protein NusA; Participates in both transcription termination and antitermination. (480 aa) |
| | KIR01556.1 | Hypothetical protein. (696 aa) |
| | KIR01569.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (278 aa) |
| | KIR01574.1 | Cobalt-precorrin-8x methylmutase. (216 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (506 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (322 aa) |
| | KIR01579.1 | Hypothetical protein. (52 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (255 aa) |
| | KIR01582.1 | Adenosylcobinamide-phosphate guanylyltransferase. (198 aa) |
| | KIR01583.1 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. (130 aa) |
| | KIR01584.1 | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. (215 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (454 aa) |
| | KIR01586.1 | Cobalt-precorrin-6y C15-methyltransferase. (606 aa) |
| | KIR01587.1 | Cobalt-precorrin-3b C17-methyltransferase. (244 aa) |
| | KIR01588.1 | Cobalt-precorrin-4 C11-methyltransferase. (252 aa) |
| | KIR01589.1 | Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (231 aa) |
| | cbiD | Cobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (361 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (380 aa) |
| | KIR01607.1 | Phosphoribosylformylglycinamidine synthaseansferase subunit. (1250 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribA | 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (201 aa) |
| | KIR01610.1 | Riboflavin synthase alpha chain. (98 aa) |
| | KIR01611.1 | Riboflavin synthase alpha chain. (115 aa) |
| | KIR01612.1 | TWA4_scaffold00001, whole genome shotgun sequence; Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase. (63 aa) |
| | KIR01613.1 | TWA4_scaffold00001, whole genome shotgun sequence; Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase. (235 aa) |
| | KIR01617.1 | Hypothetical protein. (456 aa) |
| | KIR01619.1 | Hypothetical protein. (324 aa) |
| | KIR01643.1 | Hypothetical protein. (84 aa) |
| | KIR01644.1 | Pantothenate kinase type II, eukaryotic. (163 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (427 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (342 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (224 aa) |
| | nadK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (634 aa) |
| | nusB | Transcription termination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (136 aa) |
| | KIR01681.1 | DNA-directed RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (88 aa) |
| | KIR01682.1 | Guanylate kinase. (182 aa) |
| | KIR01688.1 | DNA primase. (194 aa) |
| | KIR01689.1 | Hypothetical protein. (454 aa) |
| | KIR01694.1 | RNA polymerase sigma factor RpoD; Belongs to the sigma-70 factor family. (326 aa) |
| | KIR01715.1 | Putative hydrolase. (378 aa) |
| | KIR01727.1 | Hydrolase (HAD superfamily). (258 aa) |
| | KIR01737.1 | Hypothetical protein; FIG01031838:. (131 aa) |
| | KIR01768.1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (257 aa) |
| | KIR01769.1 | Cytidylate kinase. (216 aa) |
| | cmk | Cytidylate kinase. (223 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (310 aa) |
| | KIR01797.1 | Porphobilinogen synthase; Belongs to the ALAD family. (327 aa) |
| | KIR01798.1 | Uroporphyrinogen-III methyltransferase / Uroporphyrinogen-III synthase. (506 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (300 aa) |
| | KIR01801.1 | Hypothetical protein. (151 aa) |
| | KIR01803.1 | Hydrolase (HAD superfamily) in cluster with DUF1447. (269 aa) |
| | KIR01807.1 | RNA polymerase sigma factor RpoE; Belongs to the sigma-70 factor family. ECF subfamily. (162 aa) |
| | KIR01817.1 | Hypothetical protein. (456 aa) |
| | KIR01874.1 | 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (182 aa) |
| | KIR01876.1 | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (228 aa) |
| | KIR01911.1 | Glucosamine-1-phosphate N-acetyltransferase. (224 aa) |
| | KIR01944.1 | Putative radical SAM family enzyme, NOT coproporphyrinogen III oxidase, oxygen-independent. (456 aa) |
| | KIR01946.1 | GTP pyrophosphokinase, (p)ppGpp synthetase I; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (742 aa) |
| | KIR01948.1 | DNA polymerase III alpha subunit. (630 aa) |
| | KIR01951.1 | DNA polymerase III alpha subunit. (567 aa) |
| | KIR01961.1 | Uridine kinase. (536 aa) |
| | sigA | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (303 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (578 aa) |
| | rpoC | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1221 aa) |
| | rpoB | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1265 aa) |
| | KIR01988.1 | Hypothetical protein. (143 aa) |
| | KIR02005.1 | RNA polymerase sporulation specific sigma factor SigK; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (214 aa) |
| | KIR02019.1 | Formate dehydrogenase accessory protein FdhD; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (202 aa) |
| | KIR02020.1 | Molybdopterin-guanine dinucleotide biosynthesis protein MobB. (163 aa) |
| | KIR02021.1 | Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (336 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | KIR02023.1 | Hypothetical ATP-binding protein, containing DUF265 domain protein. (379 aa) |
| | KIR02026.1 | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (339 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (197 aa) |
| | KIR02028.1 | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (410 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa) |
| | KIR02036.1 | Aspartate carbamoyltransferase regulatory chain (PyrI). (84 aa) |
| | KIR02059.1 | RNA polymerase sporulation specific sigma factor SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (258 aa) |
| | KIR02060.1 | RNA polymerase sporulation specific sigma factor SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (237 aa) |
| | KIR02069.1 | dTDP-4-dehydrorhamnose 3,5-epimerase. (113 aa) |
| | KIR02070.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (313 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (417 aa) |
| | KIR02181.1 | Molybdopterin biosynthesis protein MoeA; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (409 aa) |
| | KIR02182.1 | Molybdenum cofactor biosynthesis protein C. (146 aa) |
| | KIR02231.1 | Cytidylate kinase. (208 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) |
| | KIR02246.1 | Hypothetical protein. (520 aa) |
| | KIR02247.1 | Uroporphyrinogen-III decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (335 aa) |
| | cbiM | Substrate-specific component CbiM of cobalt ECF transporter; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (371 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (442 aa) |
| | KIR02291.1 | Seryl-tRNA synthetase. (405 aa) |
| | KIR02298.1 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1074 aa) |
| | KIR02346.1 | Ribonucleotide reductase of class III (anaerobic), activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (160 aa) |
| | KIR02357.1 | DNA polymerase III delta prime subunit. (326 aa) |
| | KIR02370.1 | Metal-dependent hydrolases of the beta-lactamase superfamily I. (277 aa) |
| | KIR02377.1 | Seryl-tRNA synthetase. (426 aa) |
| | KIR02387.1 | Putative RNA polymerase ECF-type sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (178 aa) |
| | KIR02393.1 | Dihydrofolate synthase / Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (429 aa) |
| | KIR02398.1 | RNA polymerase sporulation specific sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (238 aa) |
| | KIR02407.1 | Hydrolase (HAD superfamily) in cluster with DUF1447. (270 aa) |
| | KIR02423.1 | UDP-glucose dehydrogenase. (419 aa) |
| | KIR02443.1 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | KIR02476.1 | ATP binding protein. (227 aa) |
| | KIR02477.1 | ATPase. (161 aa) |
| | KIR02481.1 | RNA polymerase sigma-70 factor, ECF subfamily. (161 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa) |
| | KIR02510.1 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (365 aa) |
| | KIR02596.1 | RNA polymerase sigma-54 factor RpoN; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | KIR02615.1 | Replication protein. (358 aa) |
| | KIR02622.1 | RNA polymerase sigma-54 factor RpoN; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | KIR02625.1 | RNA polymerase sigma-54 factor RpoN; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | KIR02637.1 | Methylcobalamin methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. (291 aa) |
| | KIR02638.1 | Methylcobalamin:coenzyme M methyltransferase, methanol-specific; Belongs to the uroporphyrinogen decarboxylase family. (357 aa) |
| | KIR02639.1 | Methylcobalamin methyltransferase; Belongs to the uroporphyrinogen decarboxylase family. (348 aa) |
| | KIR02640.1 | Methylcobalamin:coenzyme M methyltransferase, methanol-specific; Belongs to the uroporphyrinogen decarboxylase family. (357 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | rpoA | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (321 aa) |
| | murA-2 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (430 aa) |
| | KIR02699.1 | V-type ATP synthase subunit E. (204 aa) |
| | atpA | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (590 aa) |
| | KIR02702.1 | V-type ATP synthase subunit B. (431 aa) |
| | KIR02703.1 | V-type ATP synthase subunit D. (216 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa) |
| | thiE | Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (213 aa) |
| | KIR02717.1 | Phosphomethylpyrimidine kinase. (268 aa) |
| | KIR02718.1 | Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (223 aa) |
| | KIR02727.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (156 aa) |
| | KIR02728.1 | Hypothetical protein. (217 aa) |
| | nusG | Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. (208 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (404 aa) |
| | KIR02788.1 | Hypothetical protein. (57 aa) |
| | KIR02789.1 | Hypothetical protein. (83 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase. (425 aa) |
| | KIR02793.1 | Lipoate-protein ligase A. (310 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | KIR02896.1 | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (249 aa) |
| | KIR02898.1 | Quinolinate phosphoribosyltransferase; Belongs to the NadC/ModD family. (284 aa) |
| | KIR02910.1 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. (279 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | KIR02925.1 | Nicotinamide mononucleotide adenylyltransferase. (182 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (310 aa) |
| | KIR02942.1 | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (440 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (447 aa) |
| | trpE | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (487 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | KIR03026.1 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (232 aa) |
| | KIR03027.1 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (91 aa) |
| | KIR03028.1 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (98 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (260 aa) |
| | KIR03034.1 | Putative metal chaperone, involved in Zn homeostasis, GTPase of COG0523 family. (276 aa) |
| | KIR03052.1 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (170 aa) |
| | KIR03065.1 | Queuosine biosynthesis QueD, PTPS-I. (139 aa) |
| | queE | Queuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (214 aa) |
| | queC | Queuosine Biosynthesis QueC ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (226 aa) |
| | queF | NADPH dependent preQ0 reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (160 aa) |
| | KIR03077.1 | TWA4_scaffold00001, whole genome shotgun sequence; Acetyl-coenzyme A carboxyl transferase alpha chain / Acetyl-coenzyme A carboxyl transferase beta chain. (464 aa) |
| | thiI | Thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (396 aa) |
| | KIR03134.1 | Circadian phase modifier. (249 aa) |
| | KIR03151.1 | Hypothetical protein. (220 aa) |
| | KIR03165.1 | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa) |
| | coaX | Pantothenate kinase type III, CoaX-like protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
| | KIR03227.1 | Anaerobic sulfite reductase subunit B. (264 aa) |
| | KIR03231.1 | RNA polymerase sigma-70 factor, ECF subfamily. (161 aa) |
| | KIR03242.1 | Hydrolase (HAD superfamily) in cluster with DUF1447. (254 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (419 aa) |
| | KIR03266.1 | Para-aminobenzoate synthase, aminase component. (450 aa) |
| | KIR03268.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (280 aa) |
| | KIR03269.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (268 aa) |
| | folE | GTP cyclohydrolase I type 1. (182 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (325 aa) |
| | KIR03303.1 | Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase. (145 aa) |
| | KIR03311.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (490 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (184 aa) |
| | KIR03332.1 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa) |
| | KIR03336.1 | RNA polymerase sigma factor RpoD. (250 aa) |
| | KIR03339.1 | NimC/NimA family protein. (135 aa) |
| | KIR03340.1 | NimC/NimA family protein. (137 aa) |
| | priA | Helicase PriA essential for oriC/DnaA-independent DNA replication; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (739 aa) |
| | KIR03428.1 | Thiamin pyrophosphokinase. (145 aa) |
| | KIR03446.1 | Phage DNA polymerase. (594 aa) |
| | KIR03447.1 | Phage / plasmid primase, P4 family. (614 aa) |
| | KIR03511.1 | Molybdopterin binding motif, CinA N-terminal domain / C-terminal domain of CinA type S; Belongs to the CinA family. (166 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (375 aa) |
| | carB | Carbamoyl-phosphate synthase large chain. (1058 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (480 aa) |
| | KIR03557.1 | RNA polymerase sigma factor SigV; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | KIR03567.1 | Hypothetical protein; Belongs to the sigma-70 factor family. ECF subfamily. (166 aa) |
| | KIR03676.1 | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding protein. (162 aa) |
| | KIR03739.1 | Epoxyqueuosine (oQ) reductase QueG. (268 aa) |
| | KIR03748.1 | Uroporphyrinogen-III decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (418 aa) |
| | KIR03749.1 | Hypothetical protein. (166 aa) |
| | KIR03752.1 | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding protein. (131 aa) |
| | KIR03754.1 | Hypothetical protein. (130 aa) |
| | KIR03763.1 | RNA polymerase sigma factor RpoE; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa) |
| | KIR03781.1 | Hypothetical protein. (181 aa) |
| | KIR03786.1 | Phage encoded DNA polymerase I; FIG006036:. (664 aa) |
| | KIR03833.1 | Cof-like hydrolase. (65 aa) |
| | KIR03834.1 | Hypothetical protein. (212 aa) |
| | KIR03858.1 | Hypothetical protein. (150 aa) |
| | KIR03862.1 | RNA polymerase sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (161 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | KIR03896.1 | Hypothetical protein. (327 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (872 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa) |
| | KIR03909.1 | ACT domain protein; Belongs to the UPF0237 family. (90 aa) |
| | KIR03921.1 | Hypothetical protein. (132 aa) |
| | KIR03927.1 | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (396 aa) |
| | KIR03933.1 | IMP cyclohydrolase / Phosphoribosylaminoimidazolecarboxamide formyltransferase. (391 aa) |
| | KIR03947.1 | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein. (365 aa) |
| | KIR04010.1 | Hypothetical protein. (198 aa) |
| | KIR04036.1 | Hypothetical protein. (86 aa) |
| | sigA-2 | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (382 aa) |
| | KIR01169.1 | RNA polymerase sigma factor RpoD. (88 aa) |
| | KIR01170.1 | Protein of unknown function DUF208. (91 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | KIR01143.1 | Thymidylate synthase. (251 aa) |
