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thiI thiI guaA guaA KIR01398.1 KIR01398.1 nadD nadD KIR01512.1 KIR01512.1 KIR01513.1 KIR01513.1 glnS glnS argS argS argG argG gltX gltX tyrS tyrS cysD cysD valS valS metG metG KIR02408.1 KIR02408.1 tilS tilS tmcAL tmcAL coaD coaD mnmA mnmA KIR02925.1 KIR02925.1 ileS ileS queC queC tyrS-2 tyrS-2 KIR03165.1 KIR03165.1 cysS cysS KIR03286.1 KIR03286.1 leuS leuS KIR03378.1 KIR03378.1 KIR03531.1 KIR03531.1 KIR03896.1 KIR03896.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thiIThiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (396 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (522 aa)
KIR01398.1Conserved membrane protein of SANA family. (244 aa)
nadDHypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (204 aa)
KIR01512.1Riboflavin kinase / FMN adenylyltransferase. (226 aa)
KIR01513.1Riboflavin kinase / FMN adenylyltransferase. (84 aa)
glnSGlutaminyl-tRNA synthetase. (555 aa)
argSArginyl-tRNA synthetase. (584 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (484 aa)
tyrSTyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (406 aa)
cysDSulfate adenylyltransferase subunit 2. (299 aa)
valSValyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (880 aa)
metGMethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (646 aa)
KIR02408.1Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (304 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (459 aa)
tmcALUPF0348 protein family; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (364 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (362 aa)
KIR02925.1Nicotinamide mononucleotide adenylyltransferase. (182 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (978 aa)
queCQueuosine Biosynthesis QueC ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (226 aa)
tyrS-2Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (409 aa)
KIR03165.1NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa)
cysSCysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa)
KIR03286.1Hypothetical protein TIGR00268. (257 aa)
leuSLeucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (799 aa)
KIR03378.1tRNA(Cytosine32)-2-thiocytidine synthetase; Belongs to the TtcA family. (304 aa)
KIR03531.1Asparagine synthetase. (544 aa)
KIR03896.1Hypothetical protein. (327 aa)
Your Current Organism:
Lachnospiraceae bacterium TWA4
NCBI taxonomy Id: 1392836
Other names: L. bacterium TWA4
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