STRINGSTRING
sir sir pdxH pdxH ureB ureB serA serA AHB87496.1 AHB87496.1 thrA thrA AHB87566.1 AHB87566.1 yneI yneI pdhB pdhB acnB acnB eno eno pgl pgl sat sat cysH cysH ubiX ubiX pykF pykF gltA gltA nirA nirA narB narB glsF glsF sdhA sdhA AHB87868.1 AHB87868.1 gap2 gap2 argD argD pfk pfk accA accA pdhC pdhC accB accB rpiA rpiA pdhA pdhA fbaA fbaA AHB88080.1 AHB88080.1 dapA dapA thrC thrC glcK-1 glcK-1 rbcS rbcS rbcL rbcL cofG cofG gpmB gpmB fumC fumC prsA prsA AHB88240.1 AHB88240.1 glcD glcD cofH cofH glnA glnA cysQ cysQ accD accD hemC hemC glcF glcF glcE glcE hemA hemA sdhB sdhB lysA lysA thrB thrB metF metF accC accC lysC lysC tkt tkt pepC pepC prk prk eda-2 eda-2 gap gap pgm pgm dapB dapB comB comB hemB hemB talB talB glyA glyA cysG cysG pgk pgk pykA pykA dapF dapF hemL hemL cysK cysK gltX gltX rpe rpe ackA ackA AHB89067.1 AHB89067.1 gap1 gap1 folD folD ureC ureC asd asd gpm gpm ldhA ldhA pgi pgi ppsA ppsA cysE cysE lpdA lpdA acsA acsA AHB89480.1 AHB89480.1 tpiA tpiA hdrB hdrB ureA ureA thrCII thrCII AHB89540.1 AHB89540.1 AHB89555.1 AHB89555.1 zwf zwf fbp fbp gnd gnd AHB89608.1 AHB89608.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sirFerredoxin--sulfite reductase beta subunit Sir; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (638 aa)
pdxHPyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (211 aa)
ureBUrease beta subunit UreB; Belongs to the urease beta subunit family. (101 aa)
serAD-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
AHB87496.1Isocitrate dehydrogenase. (358 aa)
thrAHomoserine dehydrogenase ThrA. (428 aa)
AHB87566.1Bifunctional acetaldehyde-CoA/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (885 aa)
yneISuccinate-semialdehyde dehydrogenase (NADP+) YneI. (460 aa)
pdhBPyruvate dehydrogenase E1 component beta subunit PdhB; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase, AcnB; Belongs to the aconitase/IPM isomerase family. (868 aa)
eno2-phosphopyruvate hydratase (enolase) Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
pgl6-phosphogluconolactonase Pgl; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (241 aa)
satDissimilatory sulfate adenylyltransferase Sat. (398 aa)
cysHThioredoxin-dependent phosphoadenosine phosphosulfate reductase CysH; Belongs to the PAPS reductase family. CysH subfamily. (236 aa)
ubiX3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (210 aa)
pykFPyruvate kinase PykF; Belongs to the pyruvate kinase family. (477 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (382 aa)
nirAAssimilatory ferredoxin-nitrite reductase NirA; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (519 aa)
narBAssimilatory ferredoxin-nitrate reductase large subunit NarB; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (723 aa)
glsFFerredoxin-dependent glutamate synthase GlsF. (1541 aa)
sdhASuccinate dehydrogenase flavoprotein subunit SdhA. (576 aa)
AHB87868.1Dienelactone hydrolase family protein. (249 aa)
gap2NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase Gap2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (321 aa)
argDAcetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (412 aa)
pfk6-phosphofructokinase Pfk; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (369 aa)
accAacetyl-CoA carboxylase carboxyltransferase alpha subunit AccA; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa)
pdhCPyruvate dehydrogenase dihydrolipoamide acetyltransferase E2 component PdhC. (414 aa)
accBacetyl-CoA carboxylase biotin carboxyl carrier protein AccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa)
rpiARibose-5-phosphate isomerase A RpiA; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (235 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit PdhA; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa)
fbaAClass II fructose-1,6-bisphosphate aldolase FbaA; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
AHB88080.1Phosphoketolase. (812 aa)
dapADihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (286 aa)
thrCThreonine synthase ThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (362 aa)
glcK-1Glucokinase GlcK; Belongs to the bacterial glucokinase family. (327 aa)
rbcSRibulose bisphosphate carboxylase small subunit RbcS. (118 aa)
rbcLRibulose bisophosphate carboxylase large subunit RbcL; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. (475 aa)
cofG7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (315 aa)
gpmBPhosphoglycerate mutase GpmB; Belongs to the phosphoglycerate mutase family. (468 aa)
fumCFumarate hydratase class II FumC; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
prsARibose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (329 aa)
AHB88240.1Hydroxyacylglutathione hydrolase. (232 aa)
glcDGlycolate oxidase FAD-binding subunit GlcD. (487 aa)
cofH7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 CofH; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (393 aa)
glnAGlutamine synthetase type I GlnA. (471 aa)
cysQ3'-5'-bisphosphate nucleotidase CysQ. (292 aa)
accDacetyl-CoA carboxylase carboxyltransferase beta subunit AccD; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (309 aa)
hemCPorphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (320 aa)
glcFGlycolate oxidase FeS subunit GlcF. (436 aa)
glcEGlycolate oxidase subunit FAD binding subunit GlcE. (415 aa)
hemAglutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (335 aa)
lysADiaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (450 aa)
thrBHomoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa)
metF5, 10-methylenetetrahydrofolate reductase MetF; Belongs to the methylenetetrahydrofolate reductase family. (319 aa)
accCacetyl-CoA carboxylase biotin carboxylase component AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa)
lysCAspartate kinase LysC. (599 aa)
tktTransketolase Tkt; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
pepCPhosphoenolpyruvate carboxylase PepC; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1011 aa)
prkPhosphoribulokinase Prk. (334 aa)
eda-2Bifunctional 4-hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase Eda. (206 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase Gap; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgmPhosphoglucomutase Pgm. (544 aa)
dapBDihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa)
comB2-phosphosulfolactate phosphatase ComB; Belongs to the ComB family. (244 aa)
hemBDelta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. (328 aa)
talBTransaldolase TalB; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (391 aa)
glyASerine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
cysGBifunctional uroporphyrin-III synthase / uroporphyrin-III methyltransferase CysGHemD. (506 aa)
pgkPhosphoglycerate kinase PgK; Belongs to the phosphoglycerate kinase family. (400 aa)
pykAPyruvate kinase PykA; Belongs to the pyruvate kinase family. (594 aa)
dapFDiaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa)
hemLGlutamate-1-semialdehyde aminomutase HemL. (432 aa)
cysKCysteine synthase CysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (321 aa)
gltXNon-discriminating glutamyl-tRNA synthetase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (485 aa)
rpeRibulose-phosphate 3-epimerase Rpe; Belongs to the ribulose-phosphate 3-epimerase family. (231 aa)
ackAAcetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (409 aa)
AHB89067.1Thiosulfate sulfurtransferase (rhodanese-related). (279 aa)
gap1NAD-dependent glyceraldehyde-3-phosphate dehydrogenase Gap1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (306 aa)
ureCUrease alpha subunit UreC. (572 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
gpm2,3-bisphosphoglycerate-independent phosphoglycerate mutase Gpm; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (531 aa)
ldhAFermentative lactate dehydrogenase LdhA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
pgiGlucose-6-phosphate isomerase Pgi; Belongs to the GPI family. (529 aa)
ppsAPhosphoenolpyruvate synthase PpsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa)
cysESerine acetyltransferase CysE. (246 aa)
lpdADihydrolipoamide dehydrogenase IpdA. (478 aa)
acsAacetyl-CoA synthetase AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
AHB89480.13'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase CysQ. (286 aa)
tpiATriosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (243 aa)
hdrBHeterodisulfide reductase subunit B HdrB. (299 aa)
ureAUrease gamma subunit UreA; Belongs to the urease gamma subunit family. (100 aa)
thrCIIThreonine synthase ThrCII. (432 aa)
AHB89540.1Formate acetyltransferase. (755 aa)
AHB89555.1Pyruvate kinase family protein; Belongs to the pyruvate kinase family. (502 aa)
zwfGlucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
fbpFructose-1,6-bisphosphatase Fbp; Belongs to the FBPase class 1 family. (348 aa)
gnd6-phosphogluconate dehydrogenase Gnd; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (480 aa)
AHB89608.1Putative phosphoenolpyruvate synthase. (679 aa)
Your Current Organism:
Thermosynechococcus sp. NK55a
NCBI taxonomy Id: 1394889
Other names: T. sp. NK55a
Server load: low (34%) [HD]